1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. SAH

SAH (Synonyms: SAH (S-Adenosylhomocysteine))

Cat. No.: HY-19528 Purity: 98.11%
Handling Instructions

SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM.

For research use only. We do not sell to patients.

SAH Chemical Structure

SAH Chemical Structure

CAS No. : 979-92-0

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 110 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
25 mg USD 210 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM[2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

SAH (10-7-10-5 M) activates norepinephrine (NE) and serotonin (5-HT) in vitro uptake in synaptosomal preparations from rat brain, but does not affect dopamine (DA) uptake[1].
SAH (0.1-10 μM) shows strong inhibitory effects on METTL3-14 activity with an IC50 value of 0.9 µM in Kinetic parameter determination of the METTL3-14 complex[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SAH (administered i.v., i.p. or p.o. in 1-10 mg/kg) is sleep-inductive and anticonvulsant with rabbit, rat and cat[1].
SAH (intraperitoneal injection; 7 mg/kg; 1 h prior to sacrifice) induces in vitro uptake increase for NE and 5-HT, significant only in brain stem and midbrain, but does not alter DA uptake[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

384.41

Formula

C₁₄H₂₀N₆O₅S

CAS No.
SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 130 mg/mL (338.18 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6014 mL 13.0069 mL 26.0139 mL
5 mM 0.5203 mL 2.6014 mL 5.2028 mL
10 mM 0.2601 mL 1.3007 mL 2.6014 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.41 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.41 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.98 mg/mL (5.15 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.73%

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Keywords:

SAHSAH (S-Adenosylhomocysteine)Endogenous MetaboliteInhibitorinhibitorinhibit

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Product Name:
SAH
Cat. No.:
HY-19528
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