Copy Link Print Information

STM2457

108 Cited Publications
Customer Review

Based on 108 publication(s) in Google Scholar

STM2457 is a first-in-class, highly potent, selective and orally active METTL3 inhibitor with an IC50 of 16.9 nM. STM2457 can be used for the research of acute myeloid leukaemia (AML).

For research use only. We do not sell to patients.

  • Purity: 99.55%
  • CAS No.: 2499663-01-1
  • Formula: C25H28N6O2
  • Molecular Weight:444.53
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • STM2457 Chemical Structure
  • Experimental Validation Results for STM2457
  • Experimental Validation Results for STM2457
  • Experimental Validation Results for STM2457
  • Experimental Validation Results for STM2457
  • Experimental Validation Results for STM2457
  • STM2457 Chemical Structure
    STM2457 Chemical Structure
  • Experimental Validation Results for STM2457
  • Experimental Validation Results for STM2457
  • Experimental Validation Results for STM2457
  • Experimental Validation Results for STM2457
  • Experimental Validation Results for STM2457
CAS No.: 2499663-01-1
Size
Price
Stock
Quantity
Amount: USD 0.00
Please select quantity
or
or

* Please select Quantity before adding items.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Chemical Information
  • Solvent & Solubility
  • Purity & Documentation
  • References
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) STM2457

More
Customer Validation & Images
WBRT-PCRIF
  • RT-PCR
  • WB
  • IF
  • RT-PCR
  • WB
Keywords
100 mg

Get Quote In-stock

Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Sign In
Register
Sign in to MedChemExpress
Register New Account

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • STM2457 Chemical Structure
    STM2457 Chemical Structure
    1/16
  • 1/16

    STM2457 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jun 6;16(1):5251. [Abstract]

    Customer Validation
     RT-qPCR data showed m6A methylation and MAPT-paRNA expression with and without STM2457 (10 μM; 24 h) treatment in induced pluripotent stem cell (iPSC)-derived human excitatory neurons (i3Neurons).

  • 1/16

    STM2457 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Feb 14;15(1):1353. [Abstract]

    Customer Validation
     STM2457 (50.0 mg/kg, once a week for 5 weeks) was administered. The protein level of testicular METTL3 was measured. n = 6 mice.

  • 1/16

    STM2457 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Jun 26;15(1):5410. [Abstract]

    Customer Validation
     Incubated RAS-induced senescent cells with antibodies targeting YTHDF3 and TIAR when treated with DMSO or METTL3 inhibitor (2.5 μM STM2457) for 48 h.

  • 1/16

    STM2457 purchased from MedChemExpress. Usage Cited in: Nucleic Acids Res. 2024 May 9:gkae322. [Abstract]

    Customer Validation
     Presenescent WI-38 cells were incubated with the METTL3/METTL14 inhibitor STM2457 (2 μM) or with vehicle alone (DMSO) for 48 h.

  • 1/16

    STM2457 purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2022 Apr;42(4):327-344. [Abstract]

    Customer Validation
     The protein levels of PBX1 and GCH1 decreased in AGS cells treated with STM2457 (10 μM; 0–48 h), while METTL3 levels showed no change (upper panel).

  • STM2457