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Results for "

METTL3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	METTL3 (9) Apoptosis (6) DNA Methyltransferase (2) Endogenous Metabolite (4) Enterovirus (2) PROTACs (2) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (14) Infection (2) Metabolic Disease (4)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Antibodies

Targets Recommended: METTL3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS08364

METTL3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
METTL3 Human Pre-designed siRNA Set A contains three designed siRNAs for METTL3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

METTL3 Human Pre-designed siRNA Set A METTL3 Human Pre-designed siRNA Set A

HY-156759

METTL3-IN-5	METTL3	Cancer
METTL3-IN-5 (Compound 13) is a *METTL3* inhibitor. METTL3-IN-5 inhibits MOLM-13 growth with an IC₅₀ less than 2 μM. METTL3-IN-5 has weak hERG inhibitory activity (IC₅₀ >30 μM). METTL3-IN-5 can be used for AML research .

HY-148468

METTL3-IN-2

METTL3 Cancer

METTL3-IN-2 (compound 28) is a METTL3 inhibitor with an IC₅₀ value of 6.1 nM. METTL3-IN-2 inhibits cell proliferation of Caov3 cancer cells .
HY-148467

METTL3-IN-1

METTL3 Others

METTL3-IN-1 (compound 23) is a polyheterocyclic compound, acts as METTL3 inhibitor .
HY-148469

METTL3-IN-3

METTL3 Others

METTL3-IN-3 (compound 11) is a polyheterocyclic compound, acts as METTL3 inhibitor .

METTL3-IN-2	METTL3	Cancer
METTL3-IN-2 (compound 28) is a *METTL3* inhibitor with an IC₅₀ value of 6.1 nM. METTL3-IN-2 inhibits cell proliferation of Caov3 cancer cells .

METTL3-IN-1	METTL3	Others
METTL3-IN-1 (compound 23) is a polyheterocyclic compound, acts as *METTL3* inhibitor .

METTL3-IN-3	METTL3	Others
METTL3-IN-3 (compound 11) is a polyheterocyclic compound, acts as *METTL3* inhibitor .

HY-162282

*PROTAC METTL3-14 degrader 1*	DNA Methyltransferase	Cancer
PROTAC METTL3-14 degrader 1 (compound 29) is a PROTAC degrader of *METTL3-14. PROTAC METTL3-14 degrader 1 shows a 50% or higher degradation of METTL3* and/or *METTL14* .

HY-160415

WD6305	PROTACs Apoptosis	Cancer
WD6305 is a potent METTL3-targeted PROTAC degrader. WD6305 selectively reduces the METTL3 and METTL14 complex. WD6305 inhibits m ⁶A modification and the proliferation of AML cells and promotes apoptosis. WD6305 can be used for the research of leukemic .

HY-160415A

WD6305 TFA	PROTACs Apoptosis	Cancer
WD6305 TFA is a potent METTL3-targeted PROTAC degrader. WD6305 TFA selectively reduces the METTL3 and METTL14 complex. WD6305 TFA inhibits m ⁶A modification and the proliferation of AML cells and promotes apoptosis. WD6305 TFA can be used for the research of leukemic .

HY-134673A

UZH1a 1 Publications Verification	Apoptosis	Cancer
UZH1a is a potent and selective *METTL3* inhibitor, with an IC₅₀ of 280 nM. UZH1a can be used for epitranscriptomic modulation of cellular processes. UZH1a has antitumor activity. UZH1a also can be used as a chemical probe for studying METTL3 .

HY-134673

UZH1 2 Publications Verification	Apoptosis	Cancer
UZH1 is a racemate of UZH1a and UZH1b. UZH1a is a potent and selective *METTL3* inhibitor, with an IC₅₀ of 280 nM. UZH1b (IC₅₀=28 µM) is essentially inactive. UZH1 can be used for epitranscriptomic modulation of cellular processes. UZH1 has antitumor activity. UZH1 also can be used as a chemical probe for studying METTL3 .

HY-134673B

UZH1b

METTL3 Others

UZH1b is an enantiomer of UZH1a (a METTL3 inhibitor). UZH1b is essentially inactive for METTL3 (IC₅₀=28 µM) .

UZH1b	METTL3	Others
UZH1b is an enantiomer of UZH1a (a METTL3 inhibitor). UZH1b is essentially inactive for METTL3 (IC₅₀=28 µM) .

HY-19528

SAH 5+ Cited Publications SAH (S-Adenosylhomocysteine)	Endogenous Metabolite	Metabolic Disease
SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine . SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC₅₀ of 0.9 µM .

HY-153625

STM2120

METTL3 Cancer

STM2120 is a METTL3-METTL14 inhibitor with an IC₅₀ of 64.5 μM .
HY-115717

UZH2

METTL3 Cancer

UZH2 is a potent and selective METTL3 inhibitor with an IC₅₀ value of 5 nM.

STM2120	METTL3	Cancer
STM2120 is a *METTL3-METTL14* inhibitor with an IC₅₀ of 64.5 μM .

UZH2	METTL3	Cancer
UZH2 is a potent and selective *METTL3* inhibitor with an IC₅₀ value of 5 nM.

HY-19528S

SAH-d4 SAH (S-Adenosylhomocysteine)-d₄	Endogenous Metabolite	Metabolic Disease
SAH-d₄ is the deuterium labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM[2].

HY-19528S1

SAH-13C5 SAH (S-Adenosylhomocysteine)-¹³C₅	Endogenous Metabolite	Metabolic Disease
SAH- ¹³C₅ is the ¹³C-labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM[2].

HY-19528S2

SAH-13C10	Endogenous Metabolite	Metabolic Disease
SAH- ¹³C₁₀ is the ¹³C labeled SAH[1]. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[2]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 μM[3].

HY-156677

STC-15

METTL3 Cancer

STC-15 (example 70) is an orally active METTL3 inhibitor used in the study of proliferative diseases such as cancer and autoimmune diseases .
HY-156773

STM3006

Apoptosis Cancer

STM3006 is a highly potent, selective and orally active METTL3 inhibitor. STM3006 can be used for the research of acute myeloid leukaemia (AML) .
HY-154997

7OQL

METTL3 Cancer

7OQL (compound 54) is a selective METTL3 inhibitor (IC₅₀=0.054 µM). 7OQL has the potential to be used in the study of cancer .

STC-15	METTL3	Cancer
STC-15 (example 70) is an orally active *METTL3* inhibitor used in the study of proliferative diseases such as cancer and autoimmune diseases .

STM3006	Apoptosis	Cancer
STM3006 is a highly potent, selective and orally active METTL3 inhibitor. STM3006 can be used for the research of acute myeloid leukaemia (AML) .

7OQL	METTL3	Cancer
7OQL (compound 54) is a selective *METTL3* inhibitor (IC₅₀=0.054 µM). 7OQL has the potential to be used in the study of cancer .

HY-151924

Antiviral agent 23	Enterovirus	Infection
Antiviral agent 23 (compound 11b) is an antiviral agent to enterovirus 71 (EV71) with an EC₅₀ value of 94 nM. Antiviral agent 23 effectively suppresses the activity of METTL3/METTL14. Antiviral agent 23 can be used for the research of infection .

HY-134836

STM2457 Maximum Cited Publications 19 Publications Verification	Apoptosis	Cancer
STM2457 is a first-in-class, highly potent, selective and orally active *METTL3* inhibitor with an IC₅₀ of 16.9 nM. STM2457 can be used for the research of acute myeloid leukaemia (AML) .

HY-151926

Antiviral agent 24	Enterovirus	Infection
Antiviral agent 24 is a potent antiviral agent with EC₅₀ values of 0.101, 19.9, 91.2 µM for EV71, CVA21, EV68, respectively. Antiviral agent 24 inhibits METTL3/METTL14 activity in a dose-dependent manner .

HY-162082

METTL1-WDR4-IN-2	DNA Methyltransferase	Cancer
METTL1-WDR4-IN-2 (compound 6) is a selective methyltransferase Like 1 (METTL1)-WDR4 inhibitor with an IC₅₀ of 41 μM. METTL1-WDR4-IN-2 shows remarkable selectivity against METTL3-14 and slightly selective also against METTL16 .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-19528

SAH 5+ Cited Publications SAH (S-Adenosylhomocysteine)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Disease markers Metabolic Disease Amino acids Nervous System Disorder Endogenous metabolite Disease Research Fields	Endogenous Metabolite
SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine . SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC₅₀ of 0.9 µM .

Cat. No.	Product Name	Chemical Structure

HY-19528S

SAH-d4
SAH-d₄ is the deuterium labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM[2].

HY-19528S1

SAH-13C5
SAH- ¹³C₅ is the ¹³C-labeled SAH. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[1]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 µM[2].

HY-19528S2

SAH-13C10
SAH- ¹³C₁₀ is the ¹³C labeled SAH[1]. SAH (S-Adenosylhomocysteine) is an amino acid derivative and a modulartor in several metabolic pathways. It is an intermediate in the synthesis of cysteine and adenosine[2]. SAH is an inhibitor for METTL3-METTL14 heterodimer complex (METTL3-14) with an IC50 of 0.9 μM[3].

METTL3 Antibody	WB, IHC-P, FC	Human, Mouse
METTL3 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 64 kDa, targeting to METTL3. It can be used for WB,IHC-P,FC assays with tag free, in the background of Human, Mouse.

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METTL3

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Antibodies

Natural
Products