2. PROTAC Apoptosis
  3. PROTACs Apoptosis
  4. WD6305 TFA

WD6305 TFA is a potent METTL3-targeted PROTAC degrader. WD6305 TFA selectively reduces the METTL3 and METTL14 complex. WD6305 TFA inhibits m6A modification and the proliferation of AML cells and promotes apoptosis. WD6305 TFA can be used for the research of leukemic.

For research use only. We do not sell to patients.

WD6305 TFA Chemical Structure

WD6305 TFA Chemical Structure

Size Price Stock Quantity
5 mg USD 545 In-stock
10 mg USD 905 In-stock
25 mg USD 1942 In-stock
50 mg USD 3225 In-stock
100 mg   Get quote  
200 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of WD6305 TFA:

WD6305 TFA Related Antibodies

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Description

WD6305 TFA is a potent METTL3-targeted PROTAC degrader. WD6305 TFA selectively reduces the METTL3 and METTL14 complex. WD6305 TFA inhibits m6A modification and the proliferation of AML cells and promotes apoptosis. WD6305 TFA can be used for the research of leukemic[1].

Molecular Weight

1226.40

Formula

C63H76F5N11O7S
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)CCC#CC(C=C4)=CC=C4CNC5=CC(N(CC6)CCC76NC(CN(C8=CC(F)=C(CN9CCC(C)(C)CC9)C=C8F)C7)=O)=NC=N5.O=C(O)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 95 mg/mL (77.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8154 mL 4.0770 mL 8.1539 mL
5 mM 0.1631 mL 0.8154 mL 1.6308 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8154 mL 4.0770 mL 8.1539 mL 20.3849 mL
5 mM 0.1631 mL 0.8154 mL 1.6308 mL 4.0770 mL
10 mM 0.0815 mL 0.4077 mL 0.8154 mL 2.0385 mL
15 mM 0.0544 mL 0.2718 mL 0.5436 mL 1.3590 mL
20 mM 0.0408 mL 0.2038 mL 0.4077 mL 1.0192 mL
25 mM 0.0326 mL 0.1631 mL 0.3262 mL 0.8154 mL
30 mM 0.0272 mL 0.1359 mL 0.2718 mL 0.6795 mL
40 mM 0.0204 mL 0.1019 mL 0.2038 mL 0.5096 mL
50 mM 0.0163 mL 0.0815 mL 0.1631 mL 0.4077 mL
60 mM 0.0136 mL 0.0679 mL 0.1359 mL 0.3397 mL
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WD6305 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WD6305WD 6305WD-6305PROTACsApoptosisMETTL3METTL14PROTACapoptosisleukemicAMLInhibitorinhibitorinhibit

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