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Cat. No.: HY-160415

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WD6305

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

WD6305 is a potent and selective METTL3-METTL14 PROTAC degrader. WD6305 has DC₅₀ values of 140 nM and 194 nM for METTL3 and METTL14, respectively. WD6305 inhibits m⁶A modification and proliferation of AML cells, and induces apoptosis.
(Pink: METTL3 ligand (HY-115717); Blue: VHL ligand (HY-150803); Black: linker).

For research use only. We do not sell to patients.

Purity: 98.98%
CAS No.: 3066823-45-5
Formula: C₆₁H₇₅F₂N₁₁O₅S
Molecular Weight:1112.38

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

WD6305 Chemical Structure

CAS No.: 3066823-45-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

WD6305 is a potent and selective METTL3-METTL14 PROTAC degrader. WD6305 has DC₅₀ values of 140 nM and 194 nM for METTL3 and METTL14, respectively. WD6305 inhibits m⁶A modification and proliferation of AML cells, and induces apoptosis. (Pink: METTL3 ligand (HY-115717); Blue: VHL ligand (HY-150803); Black: linker).

IC₅₀ & Target

DC₅₀: 140 nM (METTL3); D_max: 91.9% (METTL3) ^[1]
DC₅₀: 194 nM (METTL14)^[1]

All PROTACs Isoforms :

In Vitro

WD6305 (20-5000 nM; 24 h) reduces METTL3 protein levels in Mono-Mac-6 cells with a DC₅₀ of 140 nM and a D_max of 91.9%^[1].
WD6305 (20-5000 nM; 24 h) reduces METTL14 protein levels in Mono-Mac-6 cells with a DC₅₀ of 194 nM^[1].
WD6305 (0.5-10 μM; 48 h) decreases the ratio of m⁶A to polyA mRNA, inhibits cell proliferation and induces cell apoptosis in Mono-Mac-6 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Mono-Mac-6 cells
Concentration:

20, 50, 100, 250, 500, 1000, 2000 and 5000 nM
Incubation Time:

24 h
Result:

Reduced METTL3 and METTL14 protein levels in a dose-dependent manner.

Western Blot Analysis^[1]

Cell Line:

Mono-Mac-6 cells
Concentration:

1 and 2.5 μM
Incubation Time:

48 h
Result:

Increased the levels of cleaved caspase-3 and cleaved PARP.

Chemical Information

CAS No. 3066823-45-5
Appearance Solid
Molecular Weight 1112.38
Formula C₆₁H₇₅F₂N₁₁O₅S
Color White to off-white
SMILES

O=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)CCC#CC(C=C4)=CC=C4CNC5=CC(N(CC6)CCC76NC(CN(C8=CC(F)=C(CN9CCC(C)(C)CC9)C=C8F)C7)=O)=NC=N5
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

Cancer Res

METTL14 Enhances Anti-Tumor Immunity through m6A-dependent loss of PD-1. [Abstract]

2025 Aug 27. PMID: 40865050
RSC Med Chem

Structure-guided design of a methyltransferase-like 3 (METTL3) proteolysis targeting chimera (PROTAC) incorporating an indole-nicotinamide chemotype. [Abstract]

2025 Jun 19. PMID: 40599585

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (89.90 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.8990 mL

4.4949 mL

8.9897 mL

5 mM

0.1798 mL

0.8990 mL

1.7979 mL

10 mM

0.0899 mL

0.4495 mL

0.8990 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Du W, et al. Discovery of a PROTAC degrader for METTL3-METTL14 complex. Cell Chem Biol. 2024 Jan 2:S2451-9456(23)00439-7. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	0.8990 mL	4.4949 mL	8.9897 mL	22.4743 mL
	5 mM	0.1798 mL	0.8990 mL	1.7979 mL	4.4949 mL
	10 mM	0.0899 mL	0.4495 mL	0.8990 mL	2.2474 mL
	15 mM	0.0599 mL	0.2997 mL	0.5993 mL	1.4983 mL
	20 mM	0.0449 mL	0.2247 mL	0.4495 mL	1.1237 mL
	25 mM	0.0360 mL	0.1798 mL	0.3596 mL	0.8990 mL
	30 mM	0.0300 mL	0.1498 mL	0.2997 mL	0.7491 mL
	40 mM	0.0225 mL	0.1124 mL	0.2247 mL	0.5619 mL
	50 mM	0.0180 mL	0.0899 mL	0.1798 mL	0.4495 mL
	60 mM	0.0150 mL	0.0749 mL	0.1498 mL	0.3746 mL
	80 mM	0.0112 mL	0.0562 mL	0.1124 mL	0.2809 mL

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (2)
Solvent & Solubility
- In Vitro
- In Vivo Dissolution Calculator
Purity & Documentation
References

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WD6305

PROTAC Library

Publications Citing Use of MedChemExpress (MCE) WD6305

All PROTACs Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

WD6305

PROTAC Library

Publications Citing Use of MedChemExpress (MCE) WD6305

All PROTACs Isoforms

Biological Activity

Chemical Information

Publications (2)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

WD6305 Related Classifications

Cat. No.: HY-160415