2. PROTAC Apoptosis
  3. PROTACs Apoptosis
  4. WD6305

WD6305 is a potent METTL3-targeted PROTAC degrader. WD6305 selectively reduces the METTL3 and METTL14 complex. WD6305 inhibits m6A modification and the proliferation of AML cells and promotes apoptosis. WD6305 can be used for the research of leukemic.

For research use only. We do not sell to patients.

WD6305 Chemical Structure

WD6305 Chemical Structure

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Description

WD6305 is a potent METTL3-targeted PROTAC degrader. WD6305 selectively reduces the METTL3 and METTL14 complex. WD6305 inhibits m6A modification and the proliferation of AML cells and promotes apoptosis. WD6305 can be used for the research of leukemic[1].

Molecular Weight

1112.38

Formula

C61H75F2N11O5S
SMILES

O=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)CCC#CC(C=C4)=CC=C4CNC5=CC(N(CC6)CCC76NC(CN(C8=CC(F)=C(CN9CCC(C)(C)CC9)C=C8F)C7)=O)=NC=N5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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WD6305 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WD6305WD 6305WD-6305PROTACsApoptosisMETTL3METTL14PROTACapoptosisleukemicAMLInhibitorinhibitorinhibit

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