VHL Ligand 14
Based on 1 Customer Validation
VHL Ligand 14 (Compound 11) is a VHL ligand for design of PROTAC estrogen receptor α (ERα) degraders, with a binding affinity IC50 of 196 nM.
For research use only. We do not sell to patients.
- Purity: 99.93%
- CAS No.: 2010986-87-3
- Formula: C25H34N4O4S
- Molecular Weight:486.63
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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VHL |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
>100000 nM
Compound: VHL-Ac
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Antiproliferative activity against human A2780 cells incubated for 72 hrs in carbon-dioxide atmosphere measured by cell counting kit-8 method
Antiproliferative activity against human A2780 cells incubated for 72 hrs in carbon-dioxide atmosphere measured by cell counting kit-8 method
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[PMID: 36563407] |
VHL Ligand 14 (5-10 μM) supports the stability of PROTAC ER degrader, promotes the ER degradation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7
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Concentration:5-10 μM
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Incubation Time:4 h
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Result:Inhibited degradation of ER ligand.
Chemical Information
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CAS No. 2010986-87-3
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Appearance Solid
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Molecular Weight 486.63
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Formula C25H34N4O4S
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Color White to off-white
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SMILES
O=C([C@H]1N(C([C@@H](NC(C)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C2=CC=C(C3=C(C)N=CS3)C=C2)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (205.49 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0549 mL | 10.2747 mL | 20.5495 mL | 51.3737 mL |
| 5 mM | 0.4110 mL | 2.0549 mL | 4.1099 mL | 10.2747 mL | |
| 10 mM | 0.2055 mL | 1.0275 mL | 2.0549 mL | 5.1374 mL | |
| 15 mM | 0.1370 mL | 0.6850 mL | 1.3700 mL | 3.4249 mL | |
| 20 mM | 0.1027 mL | 0.5137 mL | 1.0275 mL | 2.5687 mL | |
| 25 mM | 0.0822 mL | 0.4110 mL | 0.8220 mL | 2.0549 mL | |
| 30 mM | 0.0685 mL | 0.3425 mL | 0.6850 mL | 1.7125 mL | |
| 40 mM | 0.0514 mL | 0.2569 mL | 0.5137 mL | 1.2843 mL | |
| 50 mM | 0.0411 mL | 0.2055 mL | 0.4110 mL | 1.0275 mL | |
| 60 mM | 0.0342 mL | 0.1712 mL | 0.3425 mL | 0.8562 mL | |
| 80 mM | 0.0257 mL | 0.1284 mL | 0.2569 mL | 0.6422 mL | |
| 100 mM | 0.0205 mL | 0.1027 mL | 0.2055 mL | 0.5137 mL |
VHL Ligand 14 Related Classifications
HY-150803 Related Classifications
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