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Cat. No.: HY-148469

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METTL3-IN-3

METTL3-IN-3 (compound 11) is a polyheterocyclic compound, acts as METTL3 inhibitor.

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CAS No.: 2767003-71-2
화학식: C₂₆H₂₈BrFN₆O₂
분자량:555.44

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

METTL3-IN-3 Chemical Structure

CAS No.: 2767003-71-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

METTL3-IN-3 (compound 11) is a polyheterocyclic compound, acts as METTL3 inhibitor^[1].

IC₅₀ & Target

METTL3^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
Caov-3 cell line	IC₅₀	250 nM Compound: 9a	Antiproliferative activity against human Caov-3 cell line assessed as inhibition of cell proliferation incubated for 120 hrs by CellTiter-Glo assay Antiproliferative activity against human Caov-3 cell line assessed as inhibition of cell proliferation incubated for 120 hrs by CellTiter-Glo assay	[PMID: 36692498]
Kasumi 1	IC₅₀	0.95 μM Compound: 9a	Antiproliferative activity against human Kasumi 1 cells assessed as inhibition of cell proliferation incubated for 120 hrs by CellTiter-Glo assay Antiproliferative activity against human Kasumi 1 cells assessed as inhibition of cell proliferation incubated for 120 hrs by CellTiter-Glo assay	[PMID: 36692498]

In Vitro

METTL3, refers to methyltransferase-like 3, is the sole catalytic subunit of N6-methyladenosine (m6A). METTL3 is involved in the post-transcriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming m6A. m6A is the most abundant mRNA modification, so that METTL3 plays key roles in a variety of cancer types, either dependent or independent on its m6A RNA methyltransferase activity^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2767003-71-2
분자량 555.44
화학식 C₂₆H₂₈BrFN₆O₂
SMILES

O[C@H]1[C@@H](O)[C@H](N2C=C(Br)C3=C(N)N=CN=C32)C[C@@H]1C4=CC(N5)=C(C=C5CNCC6(C7)CC7(F)C6)C=C4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Blackaby WP, et al. Preparation of polyheterocyclic compounds as METTL3 inhibitors: World Intellectual Property Organization, WO2021111124[P]. 2021-06-10.

[2]. Zeng C, et al. Roles of METTL3 in cancer: mechanisms and therapeutic targeting. J Hematol Oncol. 2020 Aug 27;13(1):117. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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