1. Apoptosis
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  3. UZH1

UZH1 

Cat. No.: HY-134673
Handling Instructions

UZH1 is a racemate of UZH1a and UZH1b. UZH1a is a potent and selective METTL3 inhibitor, with an IC50 of 280 nM. UZH1b (IC50=28 µM) is essentially inactive. UZH1 can be used for epitranscriptomic modulation of cellular processes. UZH1 has antitumor activity. UZH1 also can be used as a chemical probe for studying METTL3.

For research use only. We do not sell to patients.

UZH1 Chemical Structure

UZH1 Chemical Structure

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Description

UZH1 is a racemate of UZH1a and UZH1b. UZH1a is a potent and selective METTL3 inhibitor, with an IC50 of 280 nM. UZH1b (IC50=28 µM) is essentially inactive. UZH1 can be used for epitranscriptomic modulation of cellular processes. UZH1 has antitumor activity. UZH1 also can be used as a chemical probe for studying METTL3[1].

In Vitro

UZH1a (2.5-160 µM; 72 h) inhibits the growth of MOLM-13, HEK293T, and U2Os cells, with IC50s of 11 µM, 67 µM, and 87 µM, respectively[1].
UZH1b (2.5-160 µM; 72 h) inhibits the growth of MOLM-13, HEK293T, and U2Os cells, with IC50s of 78 µM, 79 µM, and 93 µM, respectively[1].
UZH1a (2.5-100 µM; 16 h) reduces m6A methylation level in mRNA from cells in a dose-dependent manner (IC50=4.6 µM), while UZH1b is less active at concentrations up to 100 µM in MOLM-13 cells[1].
UZH1a (40 µM; 16 h) reduces m6A methylation level in mRNA from MOLM-13, HEK293T, and U2Os cells[1].
UZH1a (20 µM; 16 h) increases apoptosis and leads to cell cycle arrest in MOLM-13 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

558.71

Formula

C₃₂H₄₂N₆O₃

SMILES

O=C(NCC1(O)CN(C2=NC=NC(NCC3=CC=CC=C3)=C2)CCC1)C4=CC=C(CN5CCC(C)(C)CC5)C=C4O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

UZH1UZH 1UZH-1ApoptosisUZH1aUZH1bMETTL3epitranscriptomicantitumorchemicalprobeInhibitorinhibitorinhibit

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UZH1
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HY-134673
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