1. Epigenetics
  2. METTL3
  3. UZH1b

UZH1b is an enantiomer of UZH1a (a METTL3 inhibitor). UZH1b is essentially inactive for METTL3 (IC50=28 µM).

For research use only. We do not sell to patients.

UZH1b Chemical Structure

UZH1b Chemical Structure

CAS No. : 2814392-17-9

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5 mg USD 700 In-stock
10 mg USD 1150 In-stock
25 mg USD 2250 In-stock
50 mg USD 3500 In-stock
100 mg USD 4800 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of UZH1b:

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Description

UZH1b is an enantiomer of UZH1a (a METTL3 inhibitor). UZH1b is essentially inactive for METTL3 (IC50=28 µM)[1].

Molecular Weight

558.71

Formula

C32H42N6O3

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NC[C@]1(O)CN(C2=NC=NC(NCC3=CC=CC=C3)=C2)CCC1)C4=CC=C(CN5CCC(C)(C)CC5)C=C4O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (178.98 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7898 mL 8.9492 mL 17.8984 mL
5 mM 0.3580 mL 1.7898 mL 3.5797 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7898 mL 8.9492 mL 17.8984 mL 44.7459 mL
5 mM 0.3580 mL 1.7898 mL 3.5797 mL 8.9492 mL
10 mM 0.1790 mL 0.8949 mL 1.7898 mL 4.4746 mL
15 mM 0.1193 mL 0.5966 mL 1.1932 mL 2.9831 mL
20 mM 0.0895 mL 0.4475 mL 0.8949 mL 2.2373 mL
25 mM 0.0716 mL 0.3580 mL 0.7159 mL 1.7898 mL
30 mM 0.0597 mL 0.2983 mL 0.5966 mL 1.4915 mL
40 mM 0.0447 mL 0.2237 mL 0.4475 mL 1.1186 mL
50 mM 0.0358 mL 0.1790 mL 0.3580 mL 0.8949 mL
60 mM 0.0298 mL 0.1492 mL 0.2983 mL 0.7458 mL
80 mM 0.0224 mL 0.1119 mL 0.2237 mL 0.5593 mL
100 mM 0.0179 mL 0.0895 mL 0.1790 mL 0.4475 mL
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UZH1b Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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UZH1b
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HY-134673B
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