METTL3-IN-1
METTL3-IN-1 (compound 23) is a polyheterocyclic compound, acts as METTL3 inhibitor.
For research use only. We do not sell to patients.
- Purity: 98.07%
- CAS No.: 2648257-77-4
- Formula: C25H24FN5O2
- Molecular Weight:445.49
-
Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
-
Epigenetics Compound Library
HY-L005
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
-
Methylation Compound Library
HY-L203
-
High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
METTL3[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Caov-3 cell line | IC50 |
80 nM
Compound: 7d
|
Antiproliferative activity against human Caov-3 cell line assessed as inhibition of cell proliferation and measured after 7 days by CellTiter-Glo assay
Antiproliferative activity against human Caov-3 cell line assessed as inhibition of cell proliferation and measured after 7 days by CellTiter-Glo assay
|
[PMID: 36692498] |
| Kasumi 1 | IC50 |
263 nM
Compound: 7d
|
Antiproliferative activity against human Kasumi 1 cells assessed as inhibition of cell proliferation and measured after 7 days by CellTiter-Glo assay
Antiproliferative activity against human Kasumi 1 cells assessed as inhibition of cell proliferation and measured after 7 days by CellTiter-Glo assay
|
[PMID: 36692498] |
METTL3, refers to N6-adenosine-methyltransferase 70 kDa subunit, is the 70 kDa subunit of MT-A. MT-A is a part of N6-adenosine-methyltransferase. METTL3 is involved in the post-transcriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine (m6A)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2648257-77-4
-
Appearance Solid
-
Molecular Weight 445.49
-
Formula C25H24FN5O2
-
Color White to light yellow
-
SMILES
O=C1C=C(N=C2N1C=CC=C2)C(NCC3=CC(NC(CNCC4(C5)CC5(F)C4)=C6)=C6C=C3)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Purity & Documentation
-
Data Sheet (268 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
METTL3-IN-1 Related Classifications
HY-148467 Related Classifications
Powered by Bioz