2. Apoptosis
  3. Apoptosis
  4. STM3006

STM3006 is a highly potent, selective and orally active METTL3 inhibitor. STM3006 can be used for the research of acute myeloid leukaemia (AML).

For research use only. We do not sell to patients.

STM3006 Chemical Structure

STM3006 Chemical Structure

CAS No. : 2499664-52-5

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STM3006 Related Antibodies

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Description

STM3006 is a highly potent, selective and orally active METTL3 inhibitor. STM3006 can be used for the research of acute myeloid leukaemia (AML)[1].

Molecular Weight

519.44

Formula

C25H27BrN8
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

BrC1=CC(C2=CN(CC3=CN4C=C(CN5CCC(C)(CC5)C)C=CC4=N3)N=N2)=C6C=NNC6=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (240.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9252 mL 9.6258 mL 19.2515 mL
5 mM 0.3850 mL 1.9252 mL 3.8503 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9252 mL 9.6258 mL 19.2515 mL 48.1288 mL
5 mM 0.3850 mL 1.9252 mL 3.8503 mL 9.6258 mL
10 mM 0.1925 mL 0.9626 mL 1.9252 mL 4.8129 mL
15 mM 0.1283 mL 0.6417 mL 1.2834 mL 3.2086 mL
20 mM 0.0963 mL 0.4813 mL 0.9626 mL 2.4064 mL
25 mM 0.0770 mL 0.3850 mL 0.7701 mL 1.9252 mL
30 mM 0.0642 mL 0.3209 mL 0.6417 mL 1.6043 mL
40 mM 0.0481 mL 0.2406 mL 0.4813 mL 1.2032 mL
50 mM 0.0385 mL 0.1925 mL 0.3850 mL 0.9626 mL
60 mM 0.0321 mL 0.1604 mL 0.3209 mL 0.8021 mL
80 mM 0.0241 mL 0.1203 mL 0.2406 mL 0.6016 mL
100 mM 0.0193 mL 0.0963 mL 0.1925 mL 0.4813 mL
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STM3006 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STM30062499664-52-5STM 3006STM-3006ApoptosisInhibitorinhibitorinhibit

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