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Cat. No.: HY-148468

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METTL3-IN-2

METTL3-IN-2 (compound 28) is a METTL3 inhibitor with an IC₅₀ value of 6.1 nM. METTL3-IN-2 inhibits cell proliferation of Caov3 cancer cells.

For research use only. We do not sell to patients.

CAS No.: 2767258-88-6
Formula: C₂₅H₂₆N₈O
Molecular Weight:454.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

METTL3-IN-2 Chemical Structure

CAS No.: 2767258-88-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

METTL3-IN-2 (compound 28) is a METTL3 inhibitor with an IC₅₀ value of 6.1 nM. METTL3-IN-2 inhibits cell proliferation of Caov3 cancer cells^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Caov-3 cell line	IC₅₀	110 nM Compound: 8b	Antiproliferative activity against human Caov-3 cell line assessed as inhibition of cell proliferation incubated for 120 hrs by CellTiter-Glo assay Antiproliferative activity against human Caov-3 cell line assessed as inhibition of cell proliferation incubated for 120 hrs by CellTiter-Glo assay	[PMID: 36692498]
Kasumi 1	IC₅₀	419 nM Compound: 8b	Antiproliferative activity against human Kasumi 1 cells assessed as inhibition of cell proliferation incubated for 120 hrs by CellTiter-Glo assay Antiproliferative activity against human Kasumi 1 cells assessed as inhibition of cell proliferation incubated for 120 hrs by CellTiter-Glo assay	[PMID: 36692498]

In Vitro

METTL3-IN-2 inhibits METTL3 activity with an IC₅₀ value of 6.1 nM^[1].
METTL3-IN-2 (0-30 μM; 120 h) inhibits cell proliferation of Caov3 cells^[1].
METTL3-IN-2 (0-30 μM; 120 h) inhibits growth of KASUMI cells with an IC₅₀ value of 315.8 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

Caov3 cell line
Concentration:

0-30 μM
Incubation Time:

120 hours
Result:

Inhibited cell proliferation of Caov3 cells with an IC₅₀ value of 102.5 nM.

Chemical Information

CAS No. 2767258-88-6
Molecular Weight 454.53
Formula C₂₅H₂₆N₈O
SMILES

COC1=CN2C(C(C3=CN(CC4=CN5C(C=CC(CNCC6(C7)CC7C6)=C5)=N4)N=N3)=C1)=CN=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hardick, DJ, et al. Preparation of heteroaromatic compounds as METTL3 inhibitory compounds. WO2022074379. 2022.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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