1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. S-Adenosyl-L-methionine tosylate

S-Adenosyl-L-methionine tosylate (Synonyms: S-Adenosyl methionine tosylate; Ademetionine tosylate; AdoMet tosylate)

Cat. No.: HY-B0617A Purity: ≥98.0%
Handling Instructions

S-Adenosyl-L-methionine tosylate (S-Adenosyl methionine tosylate) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine tosylate is a dietary supplement with potent antidepressant and analgesic effects, and has the potential for liver disease and osteoarthritis research.

For research use only. We do not sell to patients.

S-Adenosyl-L-methionine tosylate Chemical Structure

S-Adenosyl-L-methionine tosylate Chemical Structure

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 93 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 93 In-stock
Estimated Time of Arrival: December 31
Solid
50 mg USD 84 In-stock
Estimated Time of Arrival: December 31
100 mg USD 108 In-stock
Estimated Time of Arrival: December 31
500 mg USD 336 In-stock
Estimated Time of Arrival: December 31
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5 g   Get quote  

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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of S-Adenosyl-L-methionine tosylate:

Top Publications Citing Use of Products

    S-Adenosyl-L-methionine tosylate purchased from MCE. Usage Cited in: Int Immunopharmacol. 2021 Mar 22;95:107545.

    S-adenosylmethionine (SAMe) application at 30 min prior to high glucose treatment significantly increased H2S levels compared with the HG group. The cystathionine-β-synthase (CBS) level is obviously elevated in HG + SAMe group compared with the HG group.
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    Description

    S-Adenosyl-L-methionine tosylate (S-Adenosyl methionine tosylate) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine tosylate is a dietary supplement with potent antidepressant and analgesic effects, and has the potential for liver disease and osteoarthritis research[1][2][3].

    In Vitro

    S-Adenosyl-L-methionine (Ademetionine) is involved in three main metabolic pathways: 1) methylation, as the principal source of methyl groups in the body; 2) transsulfuration, S-Adenosyl-L-methionine forms S-Adenosylhomocysteine (SAH) and then converted to homocysteine (Hcy) which can be converted to cystathionine then to cysteine and the sulfate (SO4) donated to other metabolic intermediates; and 3) aminopropylation, as S-Adenosyl-L-methionine plays an important role in the synthesis of polyamines which can eventually form and recycle methionine[2].
    In vitro studies using human articular chondrocytes have shown S-Adenosyl-L-methionine-induced increases in proteoglycan synthesis and proliferation rates in rabbits[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Mice lacking methionine adenosyltransferase 1a (Mat1a) have reduced hepatic S-Adenosyl-L-methionine levels and develop oxidative stress, steatohepatitis, and hepatocellular carcinoma (HCC). However, injury and HCC also occur if hepatic S-Adenosyl-L-methionine level is excessive chronically. Thus a normal hepatic S-Adenosyl-L-methionine level is necessary to maintain liver health and prevent injury and HCC[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    570.64

    Formula

    C₂₂H₃₀N₆O₈S₂

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    -20°C, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    H2O : 250 mg/mL (438.10 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7524 mL 8.7621 mL 17.5242 mL
    5 mM 0.3505 mL 1.7524 mL 3.5048 mL
    10 mM 0.1752 mL 0.8762 mL 1.7524 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
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    Product Name:
    S-Adenosyl-L-methionine tosylate
    Cat. No.:
    HY-B0617A
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