1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. S-Adenosyl-L-methionine tosylate

S-Adenosyl-L-methionine tosylate (Synonyms: Ademetionine tosylate; S-Adenosyl methionine tosylate; AdoMet tosylate)

Cat. No.: HY-B0617A
Handling Instructions

S-Adenosyl-L-methionine tosylate (Ademetionine tosylate) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine tosylate is a dietary supplement with potent antidepressant and analgesic effects, and has the potential for liver disease and osteoarthritis research.

For research use only. We do not sell to patients.

S-Adenosyl-L-methionine tosylate Chemical Structure

S-Adenosyl-L-methionine tosylate Chemical Structure

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Description

S-Adenosyl-L-methionine tosylate (Ademetionine tosylate) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine tosylate is a dietary supplement with potent antidepressant and analgesic effects, and has the potential for liver disease and osteoarthritis research[1][2][3].

In Vitro

S-Adenosyl-L-methionine (Ademetionine) is involved in three main metabolic pathways: 1) methylation, as the principal source of methyl groups in the body; 2) transsulfuration, S-Adenosyl-L-methionine forms S-Adenosylhomocysteine (SAH) and then converted to homocysteine (Hcy) which can be converted to cystathionine then to cysteine and the sulfate (SO4) donated to other metabolic intermediates; and 3) aminopropylation, as S-Adenosyl-L-methionine plays an important role in the synthesis of polyamines which can eventually form and recycle methionine[2].
In vitro studies using human articular chondrocytes have shown S-Adenosyl-L-methionine-induced increases in proteoglycan synthesis and proliferation rates in rabbits[2].

In Vivo

Mice lacking methionine adenosyltransferase 1a (Mat1a) have reduced hepatic S-Adenosyl-L-methionine levels and develop oxidative stress, steatohepatitis, and hepatocellular carcinoma (HCC). However, injury and HCC also occur if hepatic S-Adenosyl-L-methionine level is excessive chronically. Thus a normal hepatic S-Adenosyl-L-methionine level is necessary to maintain liver health and prevent injury and HCC[3].

Molecular Weight

570.64

Formula

C₂₂H₃₀N₆O₈S₂

SMILES

O[[email protected]@H]([[email protected]]([[email protected]](N1C=NC2=C1N=CN=C2N)O3)O)[[email protected]]3C[S+](CC[[email protected]](N)C([O-])=O)C.CC4=CC=C(S(=O)(O)=O)C=C4

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

S-Adenosyl-L-methionineAdemetionineS-Adenosyl methionineAdoMetEndogenous MetaboliteATPmethioninedietarysupplementadenosyltransferasemethyl antidepressantanalgesicosteoarthritisliverInhibitorinhibitorinhibit

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S-Adenosyl-L-methionine tosylate
Cat. No.:
HY-B0617A
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