1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. DNA/RNA Synthesis
    Endogenous Metabolite
  3. Folic acid

Folic acid  (Synonyms: Vitamin B9; Vitamin M)

Cat. No.: HY-16637 Purity: 99.56%
COA Handling Instructions

Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the treatment of megaloblastic and macrocytic anemias due to folic deficiency.

For research use only. We do not sell to patients.

Folic acid Chemical Structure

Folic acid Chemical Structure

CAS No. : 59-30-3

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Based on 3 publication(s) in Google Scholar

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Description

Folic acid (Vitamin B9) is a orally active essential nutrient from the B complex group of vitamins. Folic acid shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid can be used to the treatment of megaloblastic and macrocytic anemias due to folic deficiency[1][2][3][4].

IC50 & Target

Human Endogenous Metabolite

 

Microbial Metabolite

 

In Vitro

Folic acid plays a critical role in the prevention of chromosome breakage and hypomethylation of DNA[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Folic acid (10, 50, 100 mg/kg; p.o.) shows an antidepressant-like effect in this behavioral mouse model[2].
Folic acid (1, 10 nmol/site) shows no psychostimulant effect in mice habituated to the novel environment[2].
Folic acid (1, 5 mg/kg; p.o.) prevents epigenetic modification of hepatic gene expression in the offspring in rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 30-40 g swiss mice[2]
Dosage: 10, 50, 100 mg/kg
Administration: Oral administration
Result: Decreased the immobility time in the forced swimming test (FST) (F324=11.21) and produced a significant effect in the immobility time in the tail suspension test (TST) (F3,20=5.71).
Animal Model: 30-40 g swiss mice[2]
Dosage: 1-10 nmol/site
Administration: Intracerebroventrical injection
Result: Decreased the immobility time of mice in the FST (F3,22=12.31) and TST (F3,22=5.50).
Animal Model: Virgin female Wistar rats[3]
Dosage: 1, 5 mg/kg (180 g/kg protein with 1 mg/kg folic acid or 90 g/kg casein with 1, 5 mg/kg folic acid)
Administration: Oral administration
Result: Prevented epigenetic modification of hepatic gene expression in the offspring.
Clinical Trial
Molecular Weight

441.40

Formula

C19H19N7O6

CAS No.
SMILES

O=C(O)CC[[email protected]@H](C(O)=O)NC(C1=CC=C(NCC2=CN=C3N=C(N)NC(C3=N2)=O)C=C1)=O

Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

1M NaOH : 100 mg/mL (226.55 mM; Need ultrasonic)

DMSO : 33.33 mg/mL (75.51 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2655 mL 11.3276 mL 22.6552 mL
5 mM 0.4531 mL 2.2655 mL 4.5310 mL
10 mM 0.2266 mL 1.1328 mL 2.2655 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.71 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (4.71 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.56%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Folic acid
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