2. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  3. DNA/RNA Synthesis
    Endogenous Metabolite
  4. Folic acid sodium

Folic acid sodium  (Synonyms: Vitamin B9 sodium; Vitamin M sodium)

Cat. No.: HY-16637A
Handling Instructions

Folic acid (Vitamin B9) sodium is a orally active essential nutrient from the B complex group of vitamins. Folic acid sodium shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid sodium can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency.

For research use only. We do not sell to patients.

Folic acid sodium Chemical Structure

Folic acid sodium Chemical Structure

CAS No. : 6484-89-5

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Description

Folic acid (Vitamin B9) sodium is a orally active essential nutrient from the B complex group of vitamins. Folic acid sodium shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid sodium can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency[1][2][3][4].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

In Vitro

Folic acid sodium plays a critical role in the prevention of chromosome breakage and hypomethylation of DNA[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Folic acid sodium (10, 50, 100 mg/kg; p.o.) shows an antidepressant-like effect in this behavioral mouse model[2].
Folic acid sodium (1, 10 nmol/site) shows no psychostimulant effect in mice habituated to the novel environment[2].
Folic acid sodium (1, 5 mg/kg; p.o.) prevents epigenetic modification of hepatic gene expression in the offspring in rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 30-40 g swiss mice[2]
Dosage: 10, 50, 100 mg/kg
Administration: Oral administration
Result: Decreased the immobility time in the forced swimming test (FST) (F324=11.21) and produced a significant effect in the immobility time in the tail suspension test (TST) (F3,20=5.71).
Animal Model: 30-40 g swiss mice[2]
Dosage: 1-10 nmol/site
Administration: Intracerebroventrical injection
Result: Decreased the immobility time of mice in the FST (F3,22=12.31) and TST (F3,22=5.50).
Animal Model: Virgin female Wistar rats[3]
Dosage: 1, 5 mg/kg (180 g/kg protein with 1 mg/kg folic acid or 90 g/kg casein with 1, 5 mg/kg folic acid)
Administration: Oral administration
Result: Prevented epigenetic modification of hepatic gene expression in the offspring.
Clinical Trial
Molecular Weight

464.39

Formula

C19H19N7NaO6
CAS No.
SMILES

O=C(O)CC[[email protected]@H](C(O)=O)NC(C1=CC=C(NCC2=CN=C3N=C(N)NC(C3=N2)=O)C=C1)=O.[Na]
Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Folic acid6484-89-5Vitamin B9Vitamin MVitamin B 9Vitamin B-9DNA/RNA SynthesisEndogenous Metabolitenutrientntidepressant-likeneural tube defectsfolic deficiencyInhibitorinhibitorinhibit

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