Folic acid sodium
Based on 28 publication(s) in Google Scholar
Folic acid (Vitamin B9) sodium is a orally active essential nutrient from the B complex group of vitamins. Folic acid sodium shows antidepressant-like effect. Folic acid sodium reduces the risk of neonatal neural tube defects. Folic acid sodium can be used to the research of megaloblastic and macrocytic anemias due to folic deficiency.
For research use only. We do not sell to patients.
- CAS No.: 6484-89-5
- Formula: C19H19N7NaO6
- Molecular Weight:464.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Chemical Information
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Solvent & Solubility
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Publications Citing Use of MedChemExpress (MCE) Folic acid sodium
More- Bioact Mater. 2025 Apr 8:50:152-170. [Abstract]
- Autophagy. 2026 Apr 27. [Abstract]
- Nat Commun. 2024 Nov 12;15(1):9529. [Abstract]
- J Adv Res. 2025 Dec 8:S2090-1232(25)00996-8. [Abstract]
- J Nanobiotechnology. 2026 Apr 10;24(1):477. [Abstract]
- J Nanobiotechnology. 2025 Dec 5. [Abstract]
- Adv Sci (Weinh). 2024 Oct 25:e2410769. [Abstract]
- Cell Rep Med. 2023 Mar 21;4(3):100953. [Abstract]
- Cell Death Differ. 2026 May 22. [Abstract]
- Research (Wash D C). 2025 May 12:8:0653 [Abstract]
- Br J Cancer. 2023 Aug;129(3):531-540. [Abstract]
- Anal Chem. 2025 May 13;97(18):9827-9835. [Abstract]
- JCI Insight. 2022 Apr 8;7(7):e152330. [Abstract]
- Biochem Pharmacol. 2025 Oct:240:117120. [Abstract]
- Food Funct. 2026 Apr 27;17(8):3587-3599. [Abstract]
- Food Biosci. 2026 Mar 23.
- Drug Des Devel Ther. 2024 Dec 21:18:6223-6241. [Abstract]
- J Mol Med (Berl). 2019 Aug;97(8):1183-1193. [Abstract]
- Sci Rep. 2025 Apr 16;15(1):13119. [Abstract]
- Sci Rep. 2025 Jan 27;15(1):3346. [Abstract]
- Microbiol Spectr. 2023 Sep 21;11(5):e0267123. [Abstract]
- Neurotox Res. 2020 Dec;38(4):859-870. [Abstract]
- Ren Fail. 2024 Dec;46(1):2329257. [Abstract]
- J Pharm Pharmacol. 2025 Aug 21:rgaf072. [Abstract]
- In Vitro Cell Dev Biol Anim. 2025 Aug;61(7):774-788. [Abstract]
- SSRN. 2025 Sep 17.
- SSRN. 2025 Jan 14.
- bioRxiv. 2023 Jun 1.
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Biological Activity
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Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
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| KB | IC50 |
0.5 μM
Compound: folic acid
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Photocytotoxicity against human KB cells overexpressing folate receptor assessed as cell viability incubated for 24 hrs followed by halogen light illumination measured after 20 mins by MTT assay
Photocytotoxicity against human KB cells overexpressing folate receptor assessed as cell viability incubated for 24 hrs followed by halogen light illumination measured after 20 mins by MTT assay
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[PMID: 24088087] |
Folic acid sodium plays a critical role in the prevention of chromosome breakage and hypomethylation of DNA[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Folic acid sodium (1, 10 nmol/site) shows no psychostimulant effect in mice habituated to the novel environment[2].
Folic acid sodium (1, 5 mg/kg; p.o.) prevents epigenetic modification of hepatic gene expression in the offspring in rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:30-40 g swiss mice[2]
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Dosage:10, 50, 100 mg/kg
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Administration:Oral administration
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Result:Decreased the immobility time in the forced swimming test (FST) (F324=11.21) and produced a significant effect in the immobility time in the tail suspension test (TST) (F3,20=5.71).
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Animal Model:30-40 g swiss mice[2]
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Dosage:1-10 nmol/site
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Administration:Intracerebroventrical injection
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Result:Decreased the immobility time of mice in the FST (F3,22=12.31) and TST (F3,22=5.50).
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Animal Model:Virgin female Wistar rats[3]
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Dosage:1, 5 mg/kg (180 g/kg protein with 1 mg/kg folic acid or 90 g/kg casein with 1, 5 mg/kg folic acid)
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Administration:Oral administration
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Result:Prevented epigenetic modification of hepatic gene expression in the offspring.
Chemical Information
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CAS No. 6484-89-5
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Molecular Weight 464.39
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Formula C19H19N7NaO6
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SMILES
O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCC2=CN=C3N=C(N)NC(C3=N2)=O)C=C1)=O.[Na]
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Synonyms
Vitamin B9 sodium; Vitamin M sodium
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (28)
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Journal Impact Factor
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Most Recent
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Bioact Mater
Bidirectional modulation of glycolysis using a multifunctional nanocomposite hydrogel promotes bone fracture healing in type 2 diabetes mellitus. [Abstract]2025 Apr 8:50:152-170. PMID: 40256330 -
Autophagy
The nuclear receptor ESRRA is a crucial regulator of acute kidney injury through inhibition of the lipophagy-ferroptosis axis. [Abstract]2026 Apr 27. PMID: 42041131 -
Nat Commun
2024 Nov 12;15(1):9529. PMID: 39532843 -
J Adv Res
c-Myc-PANK3-EMT axis regulates the structure and function of intestinal barrier in ulcerative colitis. [Abstract]2025 Dec 8:S2090-1232(25)00996-8. PMID: 41371401
Folic acid sodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Dec 8:S2090-1232(25)00996-8. [Abstract]
Epithelial junctional proteins were upregulated by Folic acid (30 mg/kg) treated.
Folic acid sodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Dec 8:S2090-1232(25)00996-8. [Abstract]
Decreased expression of mesenchymal markers, MMPs, and EMT regulators after Folic acid (30 mg/kg) administration.
Folic acid sodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Dec 8:S2090-1232(25)00996-8. [Abstract]
Folic acid (30 mg/kg) restored epithelial architecture, as evidenced by the increase in crypt integrity, maintenance of goblet cells.
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J Nanobiotechnology
Leocarpinolide B alleviates epithelial tubular mitochondrial dysfunction via macrophage exosomal miR-204-5p/TFAM axis in AKI-CKD transition. [Abstract]2026 Apr 10;24(1):477. PMID: 41963952 -
J Nanobiotechnology
Folate-modified biomimetic nanovesicles loaded with a PU.1 inhibitor alleviate atherosclerosis by suppressing inflammation. [Abstract]2025 Dec 5. PMID: 41345629 -
Adv Sci (Weinh)
Gene Therapy for Inflammatory Cascade in Intrauterine Injury with Engineered Extracellular Vesicles Hybrid Snail Mucus-enhanced Adhesive Hydrogels. [Abstract]2024 Oct 25:e2410769. PMID: 39454114 -
Cell Rep Med
Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease. [Abstract]2023 Mar 21;4(3):100953. PMID: 36809766 -
Cell Death Differ
The E3 ubiquitin ligase Itch plays an essential role in kidney fibrosis by inhibiting Dvl2/GSK3β/β-catenin signaling pathway. [Abstract]2026 May 22. PMID: 42168361 -
Research (Wash D C)
Creating Chemiluminescence Signature Arrays Coupled with Machine Learning for Alzheimer's Disease Serum Diagnosis. [Abstract]2025 May 12:8:0653 PMID: 40357359 -
Br J Cancer
2023 Aug;129(3):531-540. PMID: 37369845 -
Anal Chem
Ultrahigh Flow Regulated Discharge Coupling with Targeted Mass Spectrometry Analysis: Real Time Capturing Biomolecules in Exhaled Breath. [Abstract]2025 May 13;97(18):9827-9835. PMID: 40302637 -
JCI Insight
2022 Apr 8;7(7):e152330. PMID: 35230979
Folic acid sodium purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 Apr 8;7(7):e152330. [Abstract]
mRNA levels of TGF-β1, α-SMA, and fibronectin in the kidney of CTL, Folic acid (FAN) (250 mg/kg, IP, 7 days), and FAN+GsMTx4 mice.
Folic acid sodium purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 Apr 8;7(7):e152330. [Abstract]
Photomicrographs of Masson’s staining in the kidney of CTL, Folic acid (FAN) (250 mg/kg, IP, 7 days), and FAN+GsMTx4 mice.
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Biochem Pharmacol
Dual inhibition of EGR1/STAT3 transcriptional hubs suppresses macrophage-driven liver fibrosis: A multi-omics-guided drug repurposing strategy. [Abstract]2025 Oct:240:117120. PMID: 40623460 -
Food Funct
Folic acid alleviates endothelial dysfunction caused by T2DM-induced ferroptosis by activating the SIRT6/NRF2/GPX4 signaling pathway. [Abstract]2026 Apr 27;17(8):3587-3599. PMID: 41906715 -
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Drug Des Devel Ther
Network Pharmacology and Metabolomics Reveal Anti-Ferroptotic Effects of Curcumin in Acute Kidney Injury. [Abstract]2024 Dec 21:18:6223-6241. PMID: 39722679 -
J Mol Med (Berl)
2019 Aug;97(8):1183-1193. PMID: 31201471 -
Sci Rep
Decitabine promotes the differentiation of poorly differentiated gastric cancer cells and enhances the sensitivity of NK cell cytotoxicity via TNF-α. [Abstract]2025 Apr 16;15(1):13119. PMID: 40240368 -
Sci Rep
UHRF1 promotes epithelial-mesenchymal transition mediating renal fibrosis by activating the TGF-β/SMAD signaling pathway. [Abstract]2025 Jan 27;15(1):3346. PMID: 39870702 -
Microbiol Spectr
Potential quorum-sensing inhibitor of Hafnia alvei H4-theaflavin-3,3´-digallate analyzed by virtual screening and molecular simulation. [Abstract]2023 Sep 21;11(5):e0267123. PMID: 37732782 -
Neurotox Res
2020 Dec;38(4):859-870. PMID: 32415528 -
Ren Fail
The relationship between thiamin, folic acid and cognitive function in a rat model of uremia. [Abstract]2024 Dec;46(1):2329257. PMID: 38482596 -
J Pharm Pharmacol
Folate-chitosan nanoparticle delivery of cannabidiol for targeted triple-negative breast cancer therapy. [Abstract]2025 Aug 21:rgaf072. PMID: 40838692 -
In Vitro Cell Dev Biol Anim
5-Methoxytryptophan improves cerebrovascular injury induced by chronic kidney disease through NF-κB pathway. [Abstract]2025 Aug;61(7):774-788. PMID: 40632423 -
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Solvent & Solubility
H2O : 100 mg/mL (215.34 mM; Need ultrasonic)
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
[1]. Butterworth CE Jr, et al. Folic acid safety and toxicity: a brief review. Am J Clin Nutr. 1989 Aug;50(2):353-8. [Content Brief]
[2]. Brocardo PS, et al. Folic acid administration produces an antidepressant-like effect in mice: evidence for the involvement of the serotonergic and noradrenergic systems. Neuropharmacology. 2008 Feb;54(2):464-73. [Content Brief]
[3]. Lillycrop KA, et al. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr. 2005 Jun;135(6):1382-6. [Content Brief]
[4]. Pietrzik K, et al. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin Pharmacokinet. 2010 Aug;49(8):535-48. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 2.1534 mL | 10.7668 mL | 21.5336 mL | 53.8341 mL |
| 5 mM | 0.4307 mL | 2.1534 mL | 4.3067 mL | 10.7668 mL | |
| 10 mM | 0.2153 mL | 1.0767 mL | 2.1534 mL | 5.3834 mL | |
| 15 mM | 0.1436 mL | 0.7178 mL | 1.4356 mL | 3.5889 mL | |
| 20 mM | 0.1077 mL | 0.5383 mL | 1.0767 mL | 2.6917 mL | |
| 25 mM | 0.0861 mL | 0.4307 mL | 0.8613 mL | 2.1534 mL | |
| 30 mM | 0.0718 mL | 0.3589 mL | 0.7178 mL | 1.7945 mL | |
| 40 mM | 0.0538 mL | 0.2692 mL | 0.5383 mL | 1.3459 mL | |
| 50 mM | 0.0431 mL | 0.2153 mL | 0.4307 mL | 1.0767 mL | |
| 60 mM | 0.0359 mL | 0.1794 mL | 0.3589 mL | 0.8972 mL | |
| 80 mM | 0.0269 mL | 0.1346 mL | 0.2692 mL | 0.6729 mL | |
| 100 mM | 0.0215 mL | 0.1077 mL | 0.2153 mL | 0.5383 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Folic acid sodium Related Classifications
HY-16637A Related Classifications
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