2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Endogenous Metabolite DNA/RNA Synthesis
  4. Folic acid disodium

Folic acid disodium  (Synonyms: Vitamin B9 disodium; Vitamin M disodium)

Cat. No.: HY-16637D Purity: 98.56%
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Folic acid disodium (Vitamin B9 disodium; Vitamin M disodium) is an orally active disodium salt form of Folic acid (HY-16637) with an intrinsic dissolution rate (IDR) of 4.96·105 g/s. Folic acid disodium serves as cofactor in single-carbon transfer reactions and exhibits protective effects against neural tube defects, ischemic events, and cancer. Folate acid disodium overload leads to impaired brain development in embryogenesis and promotes growth of precancerous altered cells. Folic acid deficiency leads to megaloblastic anemia.

For research use only. We do not sell to patients.

CAS No. : 29704-76-5

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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10 mM * 1 mL in Water In-stock
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Based on 25 publication(s) in Google Scholar

Other Forms of Folic acid disodium:

Folic acid disodium Related Antibodies

Top Publications Citing Use of Products

    Folic acid disodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Dec 8:S2090-1232(25)00996-8.  [Abstract]

    Epithelial junctional proteins were upregulated by Folic acid (30 mg/kg) treated.

    Folic acid disodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Dec 8:S2090-1232(25)00996-8.  [Abstract]

    Decreased expression of mesenchymal markers, MMPs, and EMT regulators after Folic acid (30 mg/kg) administration.

    Folic acid disodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Dec 8:S2090-1232(25)00996-8.  [Abstract]

    Folic acid (30 mg/kg) restored epithelial architecture, as evidenced by the increase in crypt integrity, maintenance of goblet cells.

    Folic acid disodium purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 Apr 8;7(7):e152330.  [Abstract]

    mRNA levels of TGF-β1, α-SMA, and fibronectin in the kidney of CTL, Folic acid (FAN) (250 mg/kg, IP, 7 days), and FAN+GsMTx4 mice.

    Folic acid disodium purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 Apr 8;7(7):e152330.  [Abstract]

    Photomicrographs of Masson’s staining in the kidney of CTL, Folic acid (FAN) (250 mg/kg, IP, 7 days), and FAN+GsMTx4 mice.

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    Description

    Folic acid disodium (Vitamin B9 disodium; Vitamin M disodium) is an orally active disodium salt form of Folic acid (HY-16637) with an intrinsic dissolution rate (IDR) of 4.96·105 g/s[1]. Folic acid disodium serves as cofactor in single-carbon transfer reactions and exhibits protective effects against neural tube defects, ischemic events, and cancer. Folate acid disodium overload leads to impaired brain development in embryogenesis and promotes growth of precancerous altered cells. Folic acid deficiency leads to megaloblastic anemia[2].

    Molecular Weight

    485.36

    Formula

    C19H17N7Na2O6
    CAS No.
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    O=C(O[Na])CC[C@@H](C(O[Na])=O)NC(C1=CC=C(NCC2=CN=C3N=C(N)NC(C3=N2)=O)C=C1)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : ≥ 100 mg/mL (206.03 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.0603 mL 10.3016 mL 20.6033 mL
    5 mM 0.4121 mL 2.0603 mL 4.1207 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 2.0603 mL 10.3016 mL 20.6033 mL 51.5082 mL
    5 mM 0.4121 mL 2.0603 mL 4.1207 mL 10.3016 mL
    10 mM 0.2060 mL 1.0302 mL 2.0603 mL 5.1508 mL
    15 mM 0.1374 mL 0.6868 mL 1.3736 mL 3.4339 mL
    20 mM 0.1030 mL 0.5151 mL 1.0302 mL 2.5754 mL
    25 mM 0.0824 mL 0.4121 mL 0.8241 mL 2.0603 mL
    30 mM 0.0687 mL 0.3434 mL 0.6868 mL 1.7169 mL
    40 mM 0.0515 mL 0.2575 mL 0.5151 mL 1.2877 mL
    50 mM 0.0412 mL 0.2060 mL 0.4121 mL 1.0302 mL
    60 mM 0.0343 mL 0.1717 mL 0.3434 mL 0.8585 mL
    80 mM 0.0258 mL 0.1288 mL 0.2575 mL 0.6439 mL
    100 mM 0.0206 mL 0.1030 mL 0.2060 mL 0.5151 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Folic acid disodium Related Classifications

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      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Folic acid disodium29704-76-5Vitamin B9 disodium Vitamin M disodiumEndogenous MetaboliteDNA/RNA Synthesisneural tube defectsischemicprecancerous altered cellsmegaloblastic anemiaInhibitorinhibitorinhibit

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