Folic acid disodium
Based on 31 publication(s) in Google Scholar
Folic acid disodium (Vitamin B9 disodium; Vitamin M disodium) is an orally active disodium salt form of Folic acid (HY-16637) with an intrinsic dissolution rate (IDR) of 4.96·105 g/s. Folic acid disodium serves as cofactor in single-carbon transfer reactions and exhibits protective effects against neural tube defects, ischemic events, and cancer. Folate acid disodium overload leads to impaired brain development in embryogenesis and promotes growth of precancerous altered cells. Folic acid deficiency leads to megaloblastic anemia.
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- Pureza : 98.56%
- No. CAS: 29704-76-5
- Fòrmula: C19H17N7Na2O6
- Peso molecular:485.36
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Folic acid disodium
More- Bioact Mater. 2025 Apr 8:50:152-170. [Abstract]
- Autophagy. 2026 Apr 27. [Abstract]
- Nat Commun. 2024 Nov 12;15(1):9529. [Abstract]
- J Adv Res. 2025 Dec 8:S2090-1232(25)00996-8. [Abstract]
- J Nanobiotechnology. 2026 Apr 10;24(1):477. [Abstract]
- J Nanobiotechnology. 2025 Dec 5. [Abstract]
- Adv Sci (Weinh). 2025 Jan;12(1):e2410769. [Abstract]
- Cell Rep Med. 2023 Mar 21;4(3):100953. [Abstract]
- Cell Death Differ. 2026 May 22. [Abstract]
- Research (Wash D C). 2025 May 12:8:0653. [Abstract]
- New Phytol. 2026 Oct;252(1):359-374. [Abstract]
- Br J Cancer. 2023 Aug;129(3):531-540. [Abstract]
- Anal Chem. 2025 May 13;97(18):9827-9835. [Abstract]
- JCI Insight. 2022 Apr 8;7(7):e152330. [Abstract]
- Biochem Pharmacol. 2025 Oct:240:117120. [Abstract]
- Food Funct. 2026 Apr 27;17(8):3587-3599. [Abstract]
- Food Biosci. 2026 Mar 23.
- Drug Des Devel Ther. 2024 Dec 21:18:6223-6241. [Abstract]
- J Mol Med (Berl). 2019 Aug;97(8):1183-1193. [Abstract]
- Sci Rep. 2025 Apr 16;15(1):13119. [Abstract]
- Sci Rep. 2025 Jan 27;15(1):3346. [Abstract]
- Microbiol Spectr. 2023 Sep 21;11(5):e0267123. [Abstract]
- Neurotox Res. 2020 Dec;38(4):859-870. [Abstract]
- Ren Fail. 2024 Dec;46(1):2329257. [Abstract]
- J Pharm Pharmacol. 2025 Aug 21:rgaf072. [Abstract]
- In Vitro Cell Dev Biol Anim. 2025 Aug;61(7):774-788. [Abstract]
- Indones J Pharm Educ. 2026;6(2).
- Biophys Rep. 2026 May.
- SSRN. 2025 Sep 17.
- SSRN. 2025 Jan 14.
- bioRxiv. 2023 Jun 1.
Customer Validation & Images
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Actividad biológica
Descripciòn
Chemical Information
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No. CAS 29704-76-5
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Appearance Solid
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Peso molecular 485.36
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Fòrmula C19H17N7Na2O6
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Color Light yellow to yellow
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SMILES
O=C(O[Na])CC[C@@H](C(O[Na])=O)NC(C1=CC=C(NCC2=CN=C3N=C(N)NC(C3=N2)=O)C=C1)=O
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Synonyms
Vitamin B9 disodium; Vitamin M disodium
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (31)
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Journal Impact Factor
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Most Recent
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Bioact Mater
Bidirectional modulation of glycolysis using a multifunctional nanocomposite hydrogel promotes bone fracture healing in type 2 diabetes mellitus. [Abstract]2025 Apr 8:50:152-170. PMID: 40256330 -
Autophagy
The nuclear receptor ESRRA is a crucial regulator of acute kidney injury through inhibition of the lipophagy-ferroptosis axis. [Abstract]2026 Apr 27. PMID: 42041131 -
Nat Commun
2024 Nov 12;15(1):9529. PMID: 39532843 -
J Adv Res
c-Myc-PANK3-EMT axis regulates the structure and function of intestinal barrier in ulcerative colitis. [Abstract]2025 Dec 8:S2090-1232(25)00996-8. PMID: 41371401
Folic acid disodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Dec 8:S2090-1232(25)00996-8. [Abstract]
Epithelial junctional proteins were upregulated by Folic acid (30 mg/kg) treated.
Folic acid disodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Dec 8:S2090-1232(25)00996-8. [Abstract]
Decreased expression of mesenchymal markers, MMPs, and EMT regulators after Folic acid (30 mg/kg) administration.
Folic acid disodium purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Dec 8:S2090-1232(25)00996-8. [Abstract]
Folic acid (30 mg/kg) restored epithelial architecture, as evidenced by the increase in crypt integrity, maintenance of goblet cells.
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J Nanobiotechnology
Leocarpinolide B alleviates epithelial tubular mitochondrial dysfunction via macrophage exosomal miR-204-5p/TFAM axis in AKI-CKD transition. [Abstract]2026 Apr 10;24(1):477. PMID: 41963952 -
J Nanobiotechnology
Folate-modified biomimetic nanovesicles loaded with a PU.1 inhibitor alleviate atherosclerosis by suppressing inflammation. [Abstract]2025 Dec 5. PMID: 41345629 -
Adv Sci (Weinh)
Gene Therapy for Inflammatory Cascade in Intrauterine Injury with Engineered Extracellular Vesicles Hybrid Snail Mucus-enhanced Adhesive Hydrogels. [Abstract]2025 Jan;12(1):e2410769. PMID: 39454114 -
Cell Rep Med
Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease. [Abstract]2023 Mar 21;4(3):100953. PMID: 36809766 -
Cell Death Differ
The E3 ubiquitin ligase Itch plays an essential role in kidney fibrosis by inhibiting Dvl2/GSK3β/β-catenin signaling pathway. [Abstract]2026 May 22. PMID: 42168361 -
Research (Wash D C)
Creating Chemiluminescence Signature Arrays Coupled with Machine Learning for Alzheimer's Disease Serum Diagnosis. [Abstract]2025 May 12:8:0653. PMID: 40357359 -
New Phytol
ZmHPATR1 orchestrates phyllosphere organic acid flux to recruit Sphingomonas and enhance resistance of maize to Curvularia leaf spot. [Abstract]2026 Oct;252(1):359-374. PMID: 42547877 -
Br J Cancer
2023 Aug;129(3):531-540. PMID: 37369845 -
Anal Chem
Ultrahigh Flow Regulated Discharge Coupling with Targeted Mass Spectrometry Analysis: Real Time Capturing Biomolecules in Exhaled Breath. [Abstract]2025 May 13;97(18):9827-9835. PMID: 40302637 -
JCI Insight
2022 Apr 8;7(7):e152330. PMID: 35230979
Folic acid disodium purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 Apr 8;7(7):e152330. [Abstract]
mRNA levels of TGF-β1, α-SMA, and fibronectin in the kidney of CTL, Folic acid (FAN) (250 mg/kg, IP, 7 days), and FAN+GsMTx4 mice.
Folic acid disodium purchased from MedChemExpress. Usage Cited in: JCI Insight. 2022 Apr 8;7(7):e152330. [Abstract]
Photomicrographs of Masson’s staining in the kidney of CTL, Folic acid (FAN) (250 mg/kg, IP, 7 days), and FAN+GsMTx4 mice.
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Biochem Pharmacol
Dual inhibition of EGR1/STAT3 transcriptional hubs suppresses macrophage-driven liver fibrosis: A multi-omics-guided drug repurposing strategy. [Abstract]2025 Oct:240:117120. PMID: 40623460 -
Food Funct
Folic acid alleviates endothelial dysfunction caused by T2DM-induced ferroptosis by activating the SIRT6/NRF2/GPX4 signaling pathway. [Abstract]2026 Apr 27;17(8):3587-3599. PMID: 41906715 -
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Drug Des Devel Ther
Network Pharmacology and Metabolomics Reveal Anti-Ferroptotic Effects of Curcumin in Acute Kidney Injury. [Abstract]2024 Dec 21:18:6223-6241. PMID: 39722679 -
J Mol Med (Berl)
2019 Aug;97(8):1183-1193. PMID: 31201471 -
Sci Rep
Decitabine promotes the differentiation of poorly differentiated gastric cancer cells and enhances the sensitivity of NK cell cytotoxicity via TNF-α. [Abstract]2025 Apr 16;15(1):13119. PMID: 40240368 -
Sci Rep
UHRF1 promotes epithelial-mesenchymal transition mediating renal fibrosis by activating the TGF-β/SMAD signaling pathway. [Abstract]2025 Jan 27;15(1):3346. PMID: 39870702 -
Microbiol Spectr
Potential quorum-sensing inhibitor of Hafnia alvei H4-theaflavin-3,3´-digallate analyzed by virtual screening and molecular simulation. [Abstract]2023 Sep 21;11(5):e0267123. PMID: 37732782 -
Neurotox Res
2020 Dec;38(4):859-870. PMID: 32415528 -
Ren Fail
The relationship between thiamin, folic acid and cognitive function in a rat model of uremia. [Abstract]2024 Dec;46(1):2329257. PMID: 38482596 -
J Pharm Pharmacol
Folate-chitosan nanoparticle delivery of cannabidiol for targeted triple-negative breast cancer therapy. [Abstract]2025 Aug 21:rgaf072. PMID: 40838692 -
In Vitro Cell Dev Biol Anim
5-Methoxytryptophan improves cerebrovascular injury induced by chronic kidney disease through NF-κB pathway. [Abstract]2025 Aug;61(7):774-788. PMID: 40632423 -
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Solvente y solubilidad
In Vitro:
H2O : ≥ 100 mg/mL (206.03 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.0603 mL | 10.3016 mL | 20.6033 mL | 51.5082 mL |
| 5 mM | 0.4121 mL | 2.0603 mL | 4.1207 mL | 10.3016 mL | |
| 10 mM | 0.2060 mL | 1.0302 mL | 2.0603 mL | 5.1508 mL | |
| 15 mM | 0.1374 mL | 0.6868 mL | 1.3736 mL | 3.4339 mL | |
| 20 mM | 0.1030 mL | 0.5151 mL | 1.0302 mL | 2.5754 mL | |
| 25 mM | 0.0824 mL | 0.4121 mL | 0.8241 mL | 2.0603 mL | |
| 30 mM | 0.0687 mL | 0.3434 mL | 0.6868 mL | 1.7169 mL | |
| 40 mM | 0.0515 mL | 0.2575 mL | 0.5151 mL | 1.2877 mL | |
| 50 mM | 0.0412 mL | 0.2060 mL | 0.4121 mL | 1.0302 mL | |
| 60 mM | 0.0343 mL | 0.1717 mL | 0.3434 mL | 0.8585 mL | |
| 80 mM | 0.0258 mL | 0.1288 mL | 0.2575 mL | 0.6439 mL | |
| 100 mM | 0.0206 mL | 0.1030 mL | 0.2060 mL | 0.5151 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Folic acid disodium Related Classifications
HY-16637D Related Classifications
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