2. Metabolic Enzyme/Protease Apoptosis
  3. Endogenous Metabolite Apoptosis
  4. S-Adenosyl-L-methionine iodide

S-Adenosyl-L-methionine iodide  (Synonyms: S-Adenosyl methionine iodide; Ademetionine iodide; AdoMet iodide)

Cat. No.: HY-14614D Purity: 84.00%
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S-Adenosyl-L-methionine (S-Adenosyl methionine) iodide is an orally active methyl group donor. S-Adenosyl-L-methionine iodide is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine iodide also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine iodide has the potential for, cancer, liver disease and osteoarthritis research.

For research use only. We do not sell to patients.

CAS No. : 3493-13-8

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Customer Review

Based on 16 publication(s) in Google Scholar

Other Forms of S-Adenosyl-L-methionine iodide:

S-Adenosyl-L-methionine iodide Related Antibodies

Top Publications Citing Use of Products

    S-Adenosyl-L-methionine iodide purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2021 Jun:95:107545.  [Abstract]

    S-adenosylmethionine (SAMe) application at 30 min prior to high glucose treatment significantly increased H2S levels compared with the HG group. The cystathionine-β-synthase (CBS) level is obviously elevated in HG + SAMe group compared with the HG group.

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    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

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    Description

    S-Adenosyl-L-methionine (S-Adenosyl methionine) iodide is an orally active methyl group donor. S-Adenosyl-L-methionine iodide is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine iodide also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine iodide has the potential for, cancer, liver disease and osteoarthritis research[1][2][3].

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    S-Adenosyl-L-methionine (300 µM, 24 or 48 h) iodide induces cell apoptosis, and promotes the cell cycle arrest in Cal-33 and JHU-SCC-011 cells[4].
    S-Adenosyl-L-methionine (300 µM, 24 h) iodide decreases the migration of the Cal-33 and JHU-SCC-011 cells[4].
    S-Adenosyl-L-methionine (5-40 μg/mL, 48 h) iodide protects the anticancer effect of 5‑FU by regulating the expression of DNMTs[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    S-Adenosyl-L-methionine iodide Related Antibodies

    Apoptosis Analysis[4]

    Cell Line: Cal-33 and JHU-SCC-011 cells
    Concentration: 300 µM
    Incubation Time: 24 h (Cal-33) or 48 h (HU-SCC-011)
    Result: Showed an approximately 10% and 3%of apoptotic cells respectively.

    Western Blot Analysis[4]

    Cell Line: Cal-33 and JHU-SCC-011 cells
    Concentration: 300 µM
    Incubation Time: 24 h (Cal-33) or 48 h (HU-SCC-011)
    Result: Decreased the expression of cyclin B1, E1 and D1 in the Cal-33 and JHU-SCC-011 cells.
    In Vivo

    S-Adenosyl-L-methionine (30 mg/kg, p.o., for 3 days) iodide prevents ASD like behaviors induced by early postnatal Valproic acid (HY-10585) exposure in young mice[6].
    S-Adenosyl-L-methionine (50 and 100 mg/kg, p.o.) iodide shows antiepileptic, memory-enhancing, and antioxidant properties in a Pentylenetetrazole-induced rat epilepsy model[7].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Valproic acid treated young mice[6]
    Dosage: 30 mg/kg
    Administration: p.o., for 3 days
    Result: Alleviated most ASD like neurobehavioral symptoms.
    Normalized the redox potential in the prefrontal cortex.
    Molecular Weight

    526.35

    Formula

    C15H23IN6O5S
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1C[S+](CC[C@H](N)C(O)=O)C.[I-]
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (94.99 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.8999 mL 9.4994 mL 18.9988 mL
    5 mM 0.3800 mL 1.8999 mL 3.7998 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 86.80%

    SDS (393 KB)

    COA (251 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.8999 mL 9.4994 mL 18.9988 mL 47.4969 mL
    5 mM 0.3800 mL 1.8999 mL 3.7998 mL 9.4994 mL
    10 mM 0.1900 mL 0.9499 mL 1.8999 mL 4.7497 mL
    15 mM 0.1267 mL 0.6333 mL 1.2666 mL 3.1665 mL
    20 mM 0.0950 mL 0.4750 mL 0.9499 mL 2.3748 mL
    25 mM 0.0760 mL 0.3800 mL 0.7600 mL 1.8999 mL
    30 mM 0.0633 mL 0.3166 mL 0.6333 mL 1.5832 mL
    40 mM 0.0475 mL 0.2375 mL 0.4750 mL 1.1874 mL
    50 mM 0.0380 mL 0.1900 mL 0.3800 mL 0.9499 mL
    60 mM 0.0317 mL 0.1583 mL 0.3166 mL 0.7916 mL
    80 mM 0.0237 mL 0.1187 mL 0.2375 mL 0.5937 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    S-Adenosyl-L-methionine iodide Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    S-Adenosyl-L-methionine3493-13-8S-Adenosyl methionineAdemetionineAdoMetEndogenous MetaboliteApoptosisInhibitorinhibitorinhibit

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