S-Adenosyl-L-methionine iodide
Based on 17 publication(s) in Google Scholar
S-Adenosyl-L-methionine (S-Adenosyl methionine) iodide is an orally active methyl group donor. S-Adenosyl-L-methionine iodide is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine iodide also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine iodide has the potential for, cancer, liver disease and osteoarthritis research.
For research use only. We do not sell to patients.
- Purity: 86.80%
- CAS No.: 3493-13-8
- Formula: C15H23IN6O5S
- Molecular Weight:526.35
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Publications Citing Use of MedChemExpress (MCE) S-Adenosyl-L-methionine iodide
More- Mol Cancer. 2025 Nov 20;24(1):295. [Abstract]
- Nat Commun. 2024 Nov 12;15(1):9529. [Abstract]
- Gut Microbes. 2025 Dec;17(1):2545434. [Abstract]
- Environ Sci Technol. 2025 Jan 14;59(1):268-278. [Abstract]
- J Exp Med. 2026 Jan 5;223(1):e20250603. [Abstract]
- J Agric Food Chem. 2021 Aug 11;69(31):8737-8746. [Abstract]
- Biochem Pharmacol. 2024 Jan:219:115967. [Abstract]
- Ind Crops Prod. 2025 Dec 2;238:122414.
- Plant J. 2025 Apr;122(2):e70182. [Abstract]
- Int Immunopharmacol. 2021 Jun:95:107545. [Abstract]
- Epigenetics Chromatin. 2021 Dec 4;14(1):52. [Abstract]
- SSRN. 2026 Jun 23.
- Biomed Pharmacother. 2025 Aug:189:118246. [Abstract]
- bioRxiv. 2025 Jun 27.
- bioRxiv. 2023 Jun 1.
- Research Square Preprint. 2021 Jun.
- Research Square Preprint. 2020 Aug.
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All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
S-Adenosyl-L-methionine (300 µM, 24 or 48 h) iodide induces cell apoptosis, and promotes the cell cycle arrest in Cal-33 and JHU-SCC-011 cells[4].
S-Adenosyl-L-methionine (300 µM, 24 h) iodide decreases the migration of the Cal-33 and JHU-SCC-011 cells[4].
S-Adenosyl-L-methionine (5-40 μg/mL, 48 h) iodide protects the anticancer effect of 5‑FU by regulating the expression of DNMTs[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Cal-33 and JHU-SCC-011 cells
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Concentration:300 µM
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Incubation Time:24 h (Cal-33) or 48 h (HU-SCC-011)
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Result:Showed an approximately 10% and 3%of apoptotic cells respectively.
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Cell Line:Cal-33 and JHU-SCC-011 cells
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Concentration:300 µM
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Incubation Time:24 h (Cal-33) or 48 h (HU-SCC-011)
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Result:Decreased the expression of cyclin B1, E1 and D1 in the Cal-33 and JHU-SCC-011 cells.
S-Adenosyl-L-methionine (50 and 100 mg/kg, p.o.) iodide shows antiepileptic, memory-enhancing, and antioxidant properties in a Pentylenetetrazole-induced rat epilepsy model[7].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Valproic acid treated young mice[6]
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Dosage:30 mg/kg
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Administration:p.o., for 3 days
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Result:Alleviated most ASD like neurobehavioral symptoms.
Normalized the redox potential in the prefrontal cortex.
Chemical Information
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CAS No. 3493-13-8
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Appearance Solid
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Molecular Weight 526.35
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Formula C15H23IN6O5S
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Color White to off-white
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1C[S+](CC[C@H](N)C(O)=O)C.[I-]
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Synonyms
S-Adenosyl methionine iodide; Ademetionine iodide; AdoMet iodide
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (17)
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Journal Impact Factor
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Most Recent
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Mol Cancer
ZNF526 drives tumor growth by enhancing SHMT1-dependent serine metabolism and antioxidant capability in TNBC. [Abstract]2025 Nov 20;24(1):295. PMID: 41267037 -
Nat Commun
2024 Nov 12;15(1):9529. PMID: 39532843 -
Gut Microbes
Gut microbiota-mediated betaine regulates skeletal muscle fiber type transition by affecting m6A RNA methylation and Myh7 expression. [Abstract]2025 Dec;17(1):2545434. PMID: 40824213 -
Environ Sci Technol
Arsenic Exposure Triggers Nonalcoholic Fatty Liver Disease through Repressing S-Adenosylmethionine-Dependent Histone Methylation in Rats. [Abstract]2025 Jan 14;59(1):268-278. PMID: 39746780 -
J Exp Med
Adenosine metabolic clearance maintains liver homeostasis by licensing arginine methylation of RIPK1. [Abstract]2026 Jan 5;223(1):e20250603. PMID: 41081715 -
J Agric Food Chem
Sesamol Epigenetically Induces Estrogen Receptor α Re-expression by Upregulating miR-370-3p in Estrogen Receptor α-Negative Breast Cancer. [Abstract]2021 Aug 11;69(31):8737-8746. PMID: 34325508 -
Biochem Pharmacol
S-adenosylmethionine attenuates angiotensin II-induced aortic dissection formation by inhibiting vascular smooth muscle cell phenotypic switch and autophagy. [Abstract]2024 Jan:219:115967. PMID: 38065291 -
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Plant J
Transcriptomic and metabolomic analyses unveil TaASMT3-mediated wheat resistance against stripe rust by promoting melatonin biosynthesis. [Abstract]2025 Apr;122(2):e70182. PMID: 40298361 -
Int Immunopharmacol
Hydrogen sulfide ameliorates high glucose-induced pro-inflammation factors in HT-22 cells: Involvement of SIRT1-mTOR/NF-κB signaling pathway. [Abstract]2021 Jun:95:107545. PMID: 33765609
S-Adenosyl-L-methionine iodide purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2021 Jun:95:107545. [Abstract]
S-adenosylmethionine (SAMe) application at 30 min prior to high glucose treatment significantly increased H2S levels compared with the HG group. The cystathionine-β-synthase (CBS) level is obviously elevated in HG + SAMe group compared with the HG group.
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Epigenetics Chromatin
Ethionine-mediated reduction of S-adenosylmethionine is responsible for the neural tube defects in the developing mouse embryo-mediated m6A modification and is involved in neural tube defects via modulating Wnt/β-catenin signaling pathway. [Abstract]2021 Dec 4;14(1):52. PMID: 34863249 -
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Biomed Pharmacother
Identification of nsp16 inhibitors of SARS -CoV-2, SARS -CoV-1 and MERS-CoV from FDA-approved drugs using in silico and in vitro methods. [Abstract]2025 Aug:189:118246. PMID: 40543162 -
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Solvent & Solubility
H2O : 50 mg/mL (94.99 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. W Wang, et al. Reversed-phase high-performance liquid chromatography procedure for the simultaneous determination of S-adenosyl-L-methionine and S-adenosyl-L-homocysteine in mouse liver and the effect of methionine on their concentrations. J Chromatogr B Biomed Sci Appl. 2001 Oct 5;762(1):59-65. [Content Brief]
[2]. Wadie I Najm, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 26;5:6. [Content Brief]
[3]. Shelly C Lu, et al. S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev. 2012 Oct;92(4):1515-42. [Content Brief]
[4]. Mosca L, et al. Effects of S‑adenosyl‑L‑methionine on the invasion and migration of head and neck squamous cancer cells and analysis of the underlying mechanisms. Int J Oncol. 2020 May;56(5):1212-1224. [Content Brief]
[5]. Ham MS, et al. S-adenosyl methionine specifically protects the anticancer effect of 5-FU via DNMTs expression in human A549 lung cancer cells. Mol Clin Oncol. 2013 Mar;1(2):373-378. [Content Brief]
[6]. Ornoy A, et al. S-adenosyl methionine prevents ASD like behaviors triggered by early postnatal valproic acid exposure in very young mice. Neurotoxicol Teratol. 2019 Jan-Feb;71:64-74. [Content Brief]
[7]. Dhediya RM, et al. Evaluation of antiepileptic effect of S-adenosyl methionine and its role in memory impairment in pentylenetetrazole-induced kindling model in rats. Epilepsy Behav. 2016 Aug;61:153-157. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 1.8999 mL | 9.4994 mL | 18.9988 mL | 47.4969 mL |
| 5 mM | 0.3800 mL | 1.8999 mL | 3.7998 mL | 9.4994 mL | |
| 10 mM | 0.1900 mL | 0.9499 mL | 1.8999 mL | 4.7497 mL | |
| 15 mM | 0.1267 mL | 0.6333 mL | 1.2666 mL | 3.1665 mL | |
| 20 mM | 0.0950 mL | 0.4750 mL | 0.9499 mL | 2.3748 mL | |
| 25 mM | 0.0760 mL | 0.3800 mL | 0.7600 mL | 1.8999 mL | |
| 30 mM | 0.0633 mL | 0.3166 mL | 0.6333 mL | 1.5832 mL | |
| 40 mM | 0.0475 mL | 0.2375 mL | 0.4750 mL | 1.1874 mL | |
| 50 mM | 0.0380 mL | 0.1900 mL | 0.3800 mL | 0.9499 mL | |
| 60 mM | 0.0317 mL | 0.1583 mL | 0.3166 mL | 0.7916 mL | |
| 80 mM | 0.0237 mL | 0.1187 mL | 0.2375 mL | 0.5937 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
S-Adenosyl-L-methionine iodide Related Classifications
HY-14614D Related Classifications
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