2. Metabolic Enzyme/Protease Apoptosis
  3. Endogenous Metabolite Apoptosis
  4. S-Adenosyl-L-methionine chloride dihydrochloride

S-Adenosyl-L-methionine chloride dihydrochloride  (Synonyms: S-Adenosyl methionine chloride dihydrochloride; Ademetionine chloride dihydrochloride; AdoMet chloride dihydrochloride)

Art. -Nr.: HY-14614A Reinheit: 75.0%
COA
SDS
Handling Instructions Technical Support

S-Adenosyl-L-methionine (S-Adenosyl methionine) chloride dihydrochloride is an orally active methyl group donor. S-Adenosyl-L-methionine chloride dihydrochloride is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine chloride dihydrochloride also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine chloride dihydrochloride has the potential for, cancer, liver disease and osteoarthritis research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr. : 86867-01-8

Größe Preis Verfügbarkeit Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 Auf Lager
Solution
10 mM * 1 mL in DMSO Auf Lager
Solid
5 mg Auf Lager
10 mg Auf Lager
25 mg Auf Lager
50 mg Auf Lager
100 mg Auf Lager
200 mg   Angebot einholen  
500 mg   Angebot einholen  

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

This product is a controlled substance and not for sale in your territory.

Kundenbewertung

Based on 7 publication(s) in Google Scholar

Other Forms of S-Adenosyl-L-methionine chloride dihydrochloride:

S-Adenosyl-L-methionine chloride dihydrochloride Related Antibodies

Top Publications Citing Use of Products

    S-Adenosyl-L-methionine chloride dihydrochloride purchased from MedChemExpress. Usage Cited in: Food Funct. 2025 Oct 27.  [Abstract]

    Representative flow cytometry plots of CD86+ and CD206+ BMDMs cultured under different treatment conditions (n = 5). The results showed that S-Adenosyl-L-methionine disulfate tosylate (SAM, 100 μM) supplementation reversed the aberrant polarization phenotype of BMDMs.

    S-Adenosyl-L-methionine chloride dihydrochloride purchased from MedChemExpress. Usage Cited in: Pharmacol Res. 2024 Sep 16:107420.  [Abstract]

    Cell viability was determined in response to JX24120 with the supplement of exogenous S-Adenosyl-L-methionine disulfate tosylate (SAMe, 5-10 μM). The results demonstrated that SAMe effectively reversed the cytotoxicity induced by JX24120 in endometrial cancer organoids and cell lines.

    S-Adenosyl-L-methionine chloride dihydrochloride purchased from MedChemExpress. Usage Cited in: Pharmacol Res. 2024 Sep 16:107420.  [Abstract]

    The protein synthesis rates of treated organoids, ISK and KLE were examined by puromycin incorporation assay. In organoids and cell lines, JX24120 inhibited protein synthesis in a dose-dependent manner, which was also rescued by exogenous supplementation with S-Adenosyl-L-methionine disulfate tosylate (SAMe, 10 μM).

    Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen:

    Alle Isoformen anzeigen
    Human Endogenous Metabolite Microbial Metabolite

    • Biologische Aktivität

    • Reinheit & Dokumentation

    • Verweise

    • Kundenbewertung

    Beschreibung

    S-Adenosyl-L-methionine (S-Adenosyl methionine) chloride dihydrochloride is an orally active methyl group donor. S-Adenosyl-L-methionine chloride dihydrochloride is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine chloride dihydrochloride also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine chloride dihydrochloride has the potential for, cancer, liver disease and osteoarthritis research[1][2][3].

    In Vitro

    S-Adenosyl-L-methionine (300 µM, 24 or 48 h) chloride dihydrochloride induces cell apoptosis, and promotes the cell cycle arrest in Cal-33 and JHU-SCC-011 cells[4].
    S-Adenosyl-L-methionine (300 µM, 24 h) chloride dihydrochloride decreases the migration of the Cal-33 and JHU-SCC-011 cells[4].
    S-Adenosyl-L-methionine (5-40 μg/mL, 48 h) chloride dihydrochloride protects the anticancer effect of 5‑FU by regulating the expression of DNMTs[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    S-Adenosyl-L-methionine chloride dihydrochloride Related Antibodies

    Apoptosis Analysis[4]

    Cell Line: Cal-33 and JHU-SCC-011 cells
    Concentration: 300 µM
    Incubation Time: 24 h (Cal-33) or 48 h (HU-SCC-011)
    Result: Showed an approximately 10% and 3%of apoptotic cells respectively.

    Western Blot Analysis[4]

    Cell Line: Cal-33 and JHU-SCC-011 cells
    Concentration: 300 µM
    Incubation Time: 24 h (Cal-33) or 48 h (HU-SCC-011)
    Result: Decreased the expression of cyclin B1, E1 and D1 in the Cal-33 and JHU-SCC-011 cells.
    In Vivo

    S-Adenosyl-L-methionine (30 mg/kg, p.o., for 3 days) chloride dihydrochloride prevents ASD like behaviors induced by early postnatal valproic acid exposure in young mice[6].
    S-Adenosyl-L-methionine (50 and 100 mg/kg, p.o.) chloride dihydrochloride shows antiepileptic, memory-enhancing, and antioxidant properties in a Pentylenetetrazole-induced rat epilepsy model[7].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Valproic acid treated young mice[6]
    Dosage: 30 mg/kg
    Administration: p.o., for 3 days
    Result: Alleviated most ASD like neurobehavioral symptoms.
    Normalized the redox potential in the prefrontal cortex.
    Molekulargewicht

    507.82

    Formel

    C15H25Cl3N6O5S
    CAS. Nr.
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1C[S+](CC[C@H](N)C(O)=O)C.[H]Cl.[H]Cl.[Cl-]
    Versand

    Room temperature in continental US; may vary elsewhere.
    Speicherung

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Lösungsmittel & Löslichkeit
    In Vitro: 

    DMSO : 100 mg/mL (196.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : ≥ 50 mg/mL (98.46 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9692 mL 9.8460 mL 19.6920 mL
    5 mM 0.3938 mL 1.9692 mL 3.9384 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molaritätsrechner

    • Verdünnungsrechner

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Reinheit & Dokumentation

    Purity: 75.0%

    SDS (393 KB)

    COA (253 KB) LCMS (97 KB)

    Handling Instructions (2659 KB)
    Verweise

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 1.9692 mL 9.8460 mL 19.6920 mL 49.2300 mL
    5 mM 0.3938 mL 1.9692 mL 3.9384 mL 9.8460 mL
    10 mM 0.1969 mL 0.9846 mL 1.9692 mL 4.9230 mL
    15 mM 0.1313 mL 0.6564 mL 1.3128 mL 3.2820 mL
    20 mM 0.0985 mL 0.4923 mL 0.9846 mL 2.4615 mL
    25 mM 0.0788 mL 0.3938 mL 0.7877 mL 1.9692 mL
    30 mM 0.0656 mL 0.3282 mL 0.6564 mL 1.6410 mL
    40 mM 0.0492 mL 0.2462 mL 0.4923 mL 1.2308 mL
    50 mM 0.0394 mL 0.1969 mL 0.3938 mL 0.9846 mL
    60 mM 0.0328 mL 0.1641 mL 0.3282 mL 0.8205 mL
    80 mM 0.0246 mL 0.1231 mL 0.2462 mL 0.6154 mL
    DMSO 100 mM 0.0197 mL 0.0985 mL 0.1969 mL 0.4923 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    S-Adenosyl-L-methionine chloride dihydrochloride Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    S-Adenosyl-L-methionine chloride86867-01-8S-Adenosyl methionine chlorideAdemetionine chlorideAdoMet chlorideEndogenous MetaboliteApoptosisInhibitorinhibitorinhibit

    Ihre kürzlich angesehenen Produkte:

    Online-Anfrage

    Your information is safe with us. * Required Fields.

    Produktname

    		  

    Requested Quantity *

    Name des Antragstellers *

    		 

    Anrede

    E-Mail-Addresse *

    		 

    Telefonnummer *

    Department

    		 

    Name der Organisation *

    City

    Bundesland

    Country or Region *

    		      

    Bemerkungen

    Massenanfrage

    Inquiry Information

    Produktname:
    S-Adenosyl-L-methionine chloride dihydrochloride
    Art. -Nr.:
    HY-14614A
    Menge:
    MCE Japan Authorized Agent:

    Kundenbewertung

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    Produktname

    		  

    Lot #

    Name des Antragstellers *

    		 

    E-Mail-Addresse *

    Telefonnummer

    		 

    Department *

    Name der Organisation *

    		 

    Country or Region *

    Bemerkungen

    SAFETY DATA SHEET (SDS)

    English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB) Italian - IT (393 KB) Korean - KR (393 KB) Portuguese - PT (393 KB)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.