(±)-α-Tocopherol acetate (Synonyms: (±)-Vitamin E acetate)

Name: (±)-α-Tocopherol acetate
Brand: MedChemExpress
SKU: HY-B1278B
Rating: 4.5 (1 reviews)

Cat. No.: HY-B1278B Purity: 99.84%: FAQs
Data Sheet SDS COA Handling Instructions

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(±)-α-Tocopherol acetate ((±)-Vitamin E acetate), is a orally active synthetic form of vitamin E. (±)-α-Tocopherol acetate is the ester of acetic acid and α-tocopherol. (±)-α-Tocopherol acetate can be used for the research of the susceptibility of farmed fish to infectious diseases.

For research use only. We do not sell to patients.

(±)-α-Tocopherol acetate Chemical Structure

CAS No. : 7695-91-2

Size	Price	Stock	Quantity
100 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
1 g	USD 60	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of (±)-α-Tocopherol acetate:

D-α-Tocopherol acetate In-stock
DL-α-Tocopherol acetate In-stock

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Description

In Vivo

(±)-α-Tocopherol acetate ((±)-Vitamin E acetate) (oral; 600 mg/kg, 1200 mg/kg, 1800 mg/kg; 15 d, 30 d and 45 d) exhibits significantly high complement activity^[1].
(±)-α-Tocopherol acetate (oral; 600 mg/kg, 1200 mg/kg, 1800 mg/kg; 15 d, 30 d and 45 d) stimulates the seabream's non-specific immune system after 30 days of administration in the diet (1200 mg/kg)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Gilthead seabream (Sparus aurata L.)^[1]
Dosage:	600 mg/kg, 1200 mg/kg, 1800 mg/kg
Administration:	oral; 600 mg/kg, 1200 mg/kg, 1800 mg/kg; 15 d,30 d and 45 d
Result:	Had a positive correlation with serum α-tocopherol levels and the increase being linked to both the dosage and length of use. Showed no enhancement in any of their immune parameters, while those fed the diet supplemented with 1200 mg/kg presented a slightly higher (but not statistically significant) specific growth rate than fish fed the other diets. Enhanced the serum haemolytic activity and the phagocytosis of head-kidney leucocytes by the dietary intake of 1200 mg/kg after 30 and 45 days, although leucocyte migration and respiratory burst activity remained unaffected. Provoked no immunostimulation in 1800 mg/kg.

Molecular Weight

472.74

Formula

C₃₁H₅₂O₃

CAS No.

7695-91-2

Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(OC(C)=O)=C(C)C(C)=C2O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (211.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1153 mL	10.5766 mL	21.1533 mL
5 mM	0.4231 mL	2.1153 mL	4.2307 mL
10 mM	0.2115 mL	1.0577 mL	2.1153 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (5.29 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (5.29 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (5.29 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.84%

Select Batch:

Data Sheet (269 KB) SDS (0 KB)

COA (241 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. J Ortuño, et al. High dietary intake of alpha-tocopherol acetate enhances the non-specific immune response of gilthead seabream (Sparus aurata L.). Fish Shellfish Immunol. 2000 May;10(4):293-307 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1153 mL	10.5766 mL	21.1533 mL	52.8832 mL
	5 mM	0.4231 mL	2.1153 mL	4.2307 mL	10.5766 mL
	10 mM	0.2115 mL	1.0577 mL	2.1153 mL	5.2883 mL
	15 mM	0.1410 mL	0.7051 mL	1.4102 mL	3.5255 mL
	20 mM	0.1058 mL	0.5288 mL	1.0577 mL	2.6442 mL
	25 mM	0.0846 mL	0.4231 mL	0.8461 mL	2.1153 mL
	30 mM	0.0705 mL	0.3526 mL	0.7051 mL	1.7628 mL
	40 mM	0.0529 mL	0.2644 mL	0.5288 mL	1.3221 mL
	50 mM	0.0423 mL	0.2115 mL	0.4231 mL	1.0577 mL
	60 mM	0.0353 mL	0.1763 mL	0.3526 mL	0.8814 mL
	80 mM	0.0264 mL	0.1322 mL	0.2644 mL	0.6610 mL
	100 mM	0.0212 mL	0.1058 mL	0.2115 mL	0.5288 mL

(±)-α-Tocopherol acetate Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(±)-α-Tocopherol7695-91-2(±)-Vitamin EBiochemical Assay Reagentsvitamin Esyntheticacetic acid and α-tocopherofishinfectiousSparus aurata L.Inhibitorinhibitorinhibit

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(±)-α-Tocopherol acetate (Synonyms: (±)-Vitamin E acetate)

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(±)-α-Tocopherol acetate Related Antibodies

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Complete Stock Solution Preparation Table

(±)-α-Tocopherol acetate Related Classifications

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