2. Autophagy Metabolic Enzyme/Protease
  3. Autophagy Endogenous Metabolite
  4. Niacin

Niacin  (Synonyms: Nicotinic acid; Vitamin B3)

Cat. No.: HY-B0143 Purity: 99.91%
COA Handling Instructions

Niacin (Vitamin B3) is an orally active water-soluble B3 vitamin that is an essential nutrient for humans. Niacin (Vitamin B3) plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin (Vitamin B3) is also used in the study of cardiovascular diseases.

For research use only. We do not sell to patients.

Niacin Chemical Structure

Niacin Chemical Structure

CAS No. : 59-67-6

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10 mM * 1 mL in DMSO
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Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of Niacin:

Niacin Related Antibodies

Top Publications Citing Use of Products

    Niacin purchased from MedChemExpress. Usage Cited in: Glia. 2018 Feb;66(2):256-278.  [Abstract]

    Representative images and quantitative analysis showing the effects of Niacin (1 mM, 10 min) and MK-6892 (10 lM, 10 min) on Akt phosphorylation levels in primary cultured microglia.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Niacin (Vitamin B3) is an orally active water-soluble B3 vitamin that is an essential nutrient for humans. Niacin (Vitamin B3) plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin (Vitamin B3) is also used in the study of cardiovascular diseases[1][2].

    IC50 & Target

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    In Vitro

    Niacin (0-900 μM, 42 hours) significantly increases GSH levels and decreases ROS levels, and affects the expression of genes related to apoptosis and lipid metabolism[1].
    Niacin (0-40 μM, 24 hours) can inhibit cancer invasive activity at low dose but with no influence on proliferation[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Niacin Related Antibodies

    RT-PCR[1]

    Cell Line: Cumulus cells and oocytes of prepubertal gilts
    Concentration: 600 μM
    Incubation Time: 42 hours
    Result: Up-regulated the relative expression of the anti-apoptotic gene BCL2 and lipid metabolism gene ACACA while down-regulated the pro-apoptotic gene BAX.

    Cell Proliferation Assay[2]

    Cell Line: Rat ascites hepatoma cell line of AH109A
    Concentration: 0-40 μM
    Incubation Time: 24 hours
    Result: Had no effect on the proliferation of AH109A cells but suppressed cell invasion from 2.5 μM to 40 μM.
    In Vivo

    Niacin (subcutaneous injection, 3-300 mg/kg, once) can induce vasodilation in a dose-dependent manner within minutes in male C57BL/6 mice[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male C57BL/6 mice[3]
    Dosage: 3-300 mg/kg
    Administration: Subcutaneous injection; once
    Result: Induced vasodilation in a dose-dependent manner.
    Clinical Trial
    Molecular Weight

    123.11

    Appearance

    Solid

    Formula

    C6H5NO2
    CAS No.
    SMILES

    O=C(C1=CC=CN=C1)O
    Structure Classification
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 1 year
    -20°C 6 months
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (406.14 mM; ultrasonic and warming and heat to 60°C)

    H2O : 10 mg/mL (81.23 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 8.1228 mL 40.6141 mL 81.2282 mL
    5 mM 1.6246 mL 8.1228 mL 16.2456 mL
    10 mM 0.8123 mL 4.0614 mL 8.1228 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  PBS

      Solubility: 110 mg/mL (893.51 mM); Clear solution; Need ultrasonic

    • 2.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: 2.08 mg/mL (16.90 mM); Suspended solution; Need ultrasonic

    • 3.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (16.90 mM); Clear solution

    • 4.

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.08 mg/mL (16.90 mM); Clear solution

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.91%

    COA (248 KB) HNMR (266 KB) LCMS (97 KB)

    Handling Instructions (2659 KB)
    References
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    Niacin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    Niacin59-67-6Nicotinic acid Vitamin B3Vitamin B3Vitamin B 3Vitamin B-3AutophagyEndogenous Metaboliteapoptosiscardiovascular diseasescancerInhibitorinhibitorinhibit

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