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    Metabolic Enzyme/Protease
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    Endogenous Metabolite

Niacin (Synonyms: Nicotinic acid; Vitamin B3)

Cat. No.: HY-B0143 Purity: >99.0%
Handling Instructions

Niacin (Vitamin B3) is a water-soluble vitamin and is part of the vitamin B group.

For research use only. We do not sell to patients.

Niacin Chemical Structure

Niacin Chemical Structure

CAS No. : 59-67-6

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in Water USD 66 In-stock
Estimated Time of Arrival: December 31
1 g USD 60 In-stock
Estimated Time of Arrival: December 31
5 g USD 78 In-stock
Estimated Time of Arrival: December 31
10 g   Get quote  
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Top Publications Citing Use of Products

    Niacin purchased from MCE. Usage Cited in: Glia. 2018 Feb;66(2):256-278.

    Representative images and quantitative analysis showing the effects of Niacin (1 mM, 10 min) and MK-6892 (10 lM, 10 min) on Akt phosphorylation levels in primary cultured microglia.
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    Description

    Niacin (Vitamin B3) is a water-soluble vitamin and is part of the vitamin B group. Target: Others Niacin (also known as vitamin B3 and nicotinic acid) is an organic compound with the formula C6H5NO2 and, depending on the definition used, one of the 20 to 80 essential human nutrients. Not enough niacin in the diet can cause nausea, skin and mouth lesions, anemia, headaches, and tiredness. Chronic Niacin deficiency leads to a disease called pellagra. The lack of niacin may also be observed in pandemic deficiency disease which is caused by a lack of five crucial vitamins: niacin,vitamin C, thiamin, vitamin D and vitamin A, and is usually found in areas of widespread poverty and malnutrition. Niacin has been used for over 50 years to increase levels of HDL in the blood and has been found to decrease the risk of cardiovascular events modestly in a number of controlled human trials. Niacin cannot be directly converted to nicotinamide, but both compounds could be converted to and are precursors of NAD and NADP in vivo.Nicotinic acid, nicotinamide, and tryptophan (via quinoline acid) are co-factors for nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). NAD converts to NADP by phosphorylation in the presence of the enzyme NAD+ kinase. NADP and NAD are coenzyme for many dehydrogenases, participating in many hydrogen transfer processes. NAD is important in catabolism of fat, carbohydrate, protein, and alcohol, as well as cell signaling and DNA repair, and NADP mostly in anabolism reactions such as fatty acid and cholesterol synthesis.High energy requirements (brain) or high turnover rate (gut, skin) organs are usually the most susceptible to their deficiency.

    Clinical Trial
    Solvent & Solubility
    In Vitro: 

    H2O : 15 mg/mL (121.84 mM; Need ultrasonic and warming)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 8.1228 mL 40.6141 mL 81.2282 mL
    5 mM 1.6246 mL 8.1228 mL 16.2456 mL
    10 mM 0.8123 mL 4.0614 mL 8.1228 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    123.11

    Formula

    C₆H₅NO₂

    CAS No.

    59-67-6

    SMILES

    O=C(C1=CC=CN=C1)O

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Purity: >99.0%

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

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    Product Name:
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    Cat. No.:
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    Cat. No.: HY-B0143