Niacin hydrochloride
Based on 12 publication(s) in Google Scholar
Niacin (Vitamin B3; Nicotinic acid) hydrochloride is an orally active B3 vitamin that is an essential nutrient for humans. Niacin hydrochloride plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin hydrochloride is also used in the study of cardiovascular diseases.
For research use only. We do not sell to patients.
- Purity: 99.36%
- CAS No.: 636-79-3
- Formula: C6H6ClNO2
- Molecular Weight:159.57
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Niacin hydrochloride
More- Mil Med Res. 2022 Aug 23;9(1):46. [Abstract]
- Mol Cell. 2023 Sep 7;83(17):3171-3187.e7. [Abstract]
- Gut Microbes. 2023 Jan-Dec;15(1):2186114. [Abstract]
- J Nanobiotechnology. 2022 Mar 9;20(1):120. [Abstract]
- J Pharm Anal. 2026 Mar 19.
- Cell Rep. 2024 Nov 26;43(11):114895. [Abstract]
- Commun Biol. 2023 Mar 2;6(1):235. [Abstract]
- Int J Mol Sci. 2025 Oct 18;26(20):10132. [Abstract]
- Int Immunopharmacol. 2025 Jun 26:159:114888. [Abstract]
- Mol Neurobiol. 2024 Nov;61(11):9302-9319. [Abstract]
- Glia. 2018 Feb;66(2):256-278. [Abstract]
- bioRxiv. 2023 Mar 29.
Customer Validation & Images
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Histological Imaging/Staining
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In Vivo Efficacy Study
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WB
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WB
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ELISA
All Endogenous Metabolite Isoforms
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Biological Activity
Description
IC50 & Target
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Microbial Metabolite |
Human Endogenous Metabolite |
In Vitro
Niacin hydrochloride (0-900 μM, 42 hours) significantly increases GSH levels and decreases ROS levels, and affects the expression of genes related to apoptosis and lipid metabolism[1].
Niacin hydrochloride (0-40 μM, 24 hours) can inhibit cancer invasive activity at low dose but with no influence on proliferation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Cumulus cells and oocytes of prepubertal gilts
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Concentration:600 μM
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Incubation Time:42 hours
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Result:Up-regulated the relative expression of the anti-apoptotic gene BCL2 and lipid metabolism gene ACACA while down-regulated the pro-apoptotic gene BAX.
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Cell Line:Rat ascites hepatoma cell line of AH109A
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Concentration:0-40 μM
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Incubation Time:24 hours
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Result:Had no effect on the proliferation of AH109A cells but suppressed cell invasion from 2.5 μM to 40 μM.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL/6 mice[3]
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Dosage:3-300 mg/kg
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Administration:Subcutaneous injection; once
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Result:Induced vasodilation in a dose-dependent manner.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 636-79-3
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Appearance Solid
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Molecular Weight 159.57
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Formula C6H6ClNO2
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Color White to off-white
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SMILES
O=C(C1=CC=CN=C1)O.Cl
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Synonyms
Nicotinic acid hydrochloride; Vitamin B3 hydrochloride
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (12)
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Journal Impact Factor
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Most Recent
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Mil Med Res
Propionate and butyrate attenuate macrophage pyroptosis and osteoclastogenesis induced by CoCrMo alloy particles. [Abstract]2022 Aug 23;9(1):46. PMID: 35996168
Niacin hydrochloride purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2022 Aug 23;9(1):46. [Abstract]
BMDMs (LPS-primed) were treated with propionate (C3, 3 mmol/L), butyrate (C4, 0.5 mmol/L), TSA (50 nmol/L), Panobinostat (25 nmol/L), AR42062 (25 μmol/L), 4-CMTB (100 μmol/L), and niacin (1 mmol/L; 6 h) and then stimulated with CoCrMo alloy particles.
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Mol Cell
2023 Sep 7;83(17):3171-3187.e7. PMID: 37597514 -
Gut Microbes
2023 Jan-Dec;15(1):2186114. PMID: 36941257 -
J Nanobiotechnology
The ketone body β-hydroxybutyrate alleviates CoCrMo alloy particles induced osteolysis by regulating NLRP3 inflammasome and osteoclast differentiation. [Abstract]2022 Mar 9;20(1):120. PMID: 35264201
Niacin hydrochloride purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2022 Mar 9;20(1):120. [Abstract]
BMDMs (LPS-primed) were treated with different doses of BHB, Niacin (100 μM; 6 h), TSA (50 nM), and LBH589 (25 nM) and stimulated with CoCrMo particles. Supernatants were collected for Caspase-1 and IL-1β detection by western blot.
Niacin hydrochloride purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2022 Mar 9;20(1):120. [Abstract]
BMDMs (LPS-primed) were treated with different doses of BHB, Niacin (100 μM; 6 h), TSA (50 nM), and LBH589 (25 nM) and stimulated with CoCrMo particles. IL-1β was analyzed by ELISA in the supernatants.
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Cell Rep
Structural basis for ligand recognition of the human hydroxycarboxylic acid receptor HCAR3. [Abstract]2024 Nov 26;43(11):114895. PMID: 39427321 -
Commun Biol
Bacterial PncA improves diet-induced NAFLD in mice by enabling the transition from nicotinamide to nicotinic acid. [Abstract]2023 Mar 2;6(1):235. PMID: 36864222
Niacin hydrochloride purchased from MedChemExpress. Usage Cited in: Commun Biol. 2023 Mar 2;6(1):235. [Abstract]
Niacin (400 mg/kg/day). Body weight of mice during the experiment after supplementation with the MCD diet decreased gradually.
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Int J Mol Sci
2025 Oct 18;26(20):10132. PMID: 41155424
Niacin hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Oct 18;26(20):10132. [Abstract]
Seven-week-old male C57BL/6 mice were shaved and treated topically with vehicle, 3% rebamipide, 0.5% niacin (NA, lipolysis inhibitor), 0.05% rosiglitazone (RSG, PPARγ agonist), or combination therapies for 26 days (n = 6 for each group). Photographs were taken on day 26 post-treatment. H&E staining of skin sections revealed hair follicle morphology. Ki67 immunofluorescent staining showed that rebamipide-induced hair regeneration was inhibited by NA and RSG.
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Int Immunopharmacol
Early-life antibiotic dysbiosis impairs microbial tryptophan- nicotinic acid metabolism exacerbating food allergy in adulthood. [Abstract]2025 Jun 26:159:114888. PMID: 40403504 -
Mol Neurobiol
Brain Immune Cell Infiltration and Serum Metabolomic Characteristics Reveal that Lauric Acid Promotes Immune Cell Infiltration in Brain and Streptococcus suis Meningitis in Mice. [Abstract]2024 Nov;61(11):9302-9319. PMID: 38625620 -
Glia
The ketone body metabolite β-hydroxybutyrate induces an antidepression-associated ramification of microglia via HDACs inhibition-triggered Akt-small RhoGTPase activation. [Abstract]2018 Feb;66(2):256-278. PMID: 29058362
Niacin hydrochloride purchased from MedChemExpress. Usage Cited in: Glia. 2018 Feb;66(2):256-278. [Abstract]
Representative images and quantitative analysis showing the effects of Niacin (1 mM, 10 min) and MK-6892 (10 lM, 10 min) on Akt phosphorylation levels in primary cultured microglia.
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Solvent & Solubility
In Vitro:
H2O : 50 mg/mL (313.34 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Areeg M Almubarak, et al. Supplementation with Niacin during in vitro maturation improves the quality of porcine embryos. Theriogenology. 2021 Jul 15;169:36-46. doi: 10.1016/j.theriogenology.2021.04.005. Epub 2021 Apr 18. [Content Brief]
[2]. Nobuhiro Hirakawa, et al. Anti-invasive activity of niacin and trigonelline against cancer cells. Biosci Biotechnol Biochem. 2005 Mar;69(3):653-8. [Content Brief]
[3]. Kang Cheng, et al. Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6682-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 6.2668 mL | 31.3342 mL | 62.6684 mL | 156.6710 mL |
| 5 mM | 1.2534 mL | 6.2668 mL | 12.5337 mL | 31.3342 mL | |
| 10 mM | 0.6267 mL | 3.1334 mL | 6.2668 mL | 15.6671 mL | |
| 15 mM | 0.4178 mL | 2.0889 mL | 4.1779 mL | 10.4447 mL | |
| 20 mM | 0.3133 mL | 1.5667 mL | 3.1334 mL | 7.8336 mL | |
| 25 mM | 0.2507 mL | 1.2534 mL | 2.5067 mL | 6.2668 mL | |
| 30 mM | 0.2089 mL | 1.0445 mL | 2.0889 mL | 5.2224 mL | |
| 40 mM | 0.1567 mL | 0.7834 mL | 1.5667 mL | 3.9168 mL | |
| 50 mM | 0.1253 mL | 0.6267 mL | 1.2534 mL | 3.1334 mL | |
| 60 mM | 0.1044 mL | 0.5222 mL | 1.0445 mL | 2.6112 mL | |
| 80 mM | 0.0783 mL | 0.3917 mL | 0.7834 mL | 1.9584 mL | |
| 100 mM | 0.0627 mL | 0.3133 mL | 0.6267 mL | 1.5667 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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