Niacin-d4
Based on 1 publication(s) in Google Scholar
Niacin-d4 is the deuterium labeled Niacin. Niacin (Nicotinic acid) is a vitamin and is part of the vitamin B group.
For research use only. We do not sell to patients.
- Purity: 99.61%
- CAS No.: 66148-15-0
- Formula: C6HD4NO2
- Molecular Weight:127.13
-
Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Niacin-d4
MoreAll Endogenous Metabolite Isoforms
More
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS No. 66148-15-0
-
Unlabeled Cas 59-67-6
-
Appearance Solid
-
Molecular Weight 127.13
-
Formula C6HD4NO2
-
Color White to off-white
-
SMILES
OC(C1=C([2H])N=C([2H])C([2H])=C1[2H])=O
-
Synonyms
Nicotinic acid-d4; Vitamin B3-d4
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Int Immunopharmacol
The niacin receptor HCAR2 prevents sleep deprivation-induced cognitive impairment by inhibiting microglia-mediated neuroinflammation in mice. [Abstract]2025 Sep 23:162:115174. PMID: 40617043
Solvent & Solubility
DMSO : 83.33 mg/mL (655.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (274 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. ;Bruckert E, et al. Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and ath [Content Brief]
[2]. Bruckert E, et al. Meta-analysis of the effect of nicotinic acid alone or in combination on cardiovascular events and atherosclerosis. Atherosclerosis. 2010 Jun;210(2):353-61. [Content Brief]
[3]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.8660 mL | 39.3298 mL | 78.6596 mL | 196.6491 mL |
| 5 mM | 1.5732 mL | 7.8660 mL | 15.7319 mL | 39.3298 mL | |
| 10 mM | 0.7866 mL | 3.9330 mL | 7.8660 mL | 19.6649 mL | |
| 15 mM | 0.5244 mL | 2.6220 mL | 5.2440 mL | 13.1099 mL | |
| 20 mM | 0.3933 mL | 1.9665 mL | 3.9330 mL | 9.8325 mL | |
| 25 mM | 0.3146 mL | 1.5732 mL | 3.1464 mL | 7.8660 mL | |
| 30 mM | 0.2622 mL | 1.3110 mL | 2.6220 mL | 6.5550 mL | |
| 40 mM | 0.1966 mL | 0.9832 mL | 1.9665 mL | 4.9162 mL | |
| 50 mM | 0.1573 mL | 0.7866 mL | 1.5732 mL | 3.9330 mL | |
| 60 mM | 0.1311 mL | 0.6555 mL | 1.3110 mL | 3.2775 mL | |
| 80 mM | 0.0983 mL | 0.4916 mL | 0.9832 mL | 2.4581 mL | |
| 100 mM | 0.0787 mL | 0.3933 mL | 0.7866 mL | 1.9665 mL |
Powered by Bioz