1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. S-Adenosyl-L-methionine

S-Adenosyl-L-methionine (Synonyms: S-Adenosyl methionine; Ademetionine; AdoMet)

Cat. No.: HY-B0617
Handling Instructions

S-Adenosyl-L-methionine (S-Adenosyl methionine) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant and analgesic effects, and has the potential for liver disease and osteoarthritis research.

For research use only. We do not sell to patients.

S-Adenosyl-L-methionine Chemical Structure

S-Adenosyl-L-methionine Chemical Structure

CAS No. : 29908-03-0

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Description

S-Adenosyl-L-methionine (S-Adenosyl methionine) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant and analgesic effects, and has the potential for liver disease and osteoarthritis research[1][2][3].

In Vitro

S-Adenosyl-L-methionine (Ademetionine) is involved in three main metabolic pathways: 1) methylation, as the principal source of methyl groups in the body; 2) transsulfuration, S-Adenosyl-L-methionine forms S-Adenosylhomocysteine (SAH) and then converted to homocysteine (Hcy) which can be converted to cystathionine then to cysteine and the sulfate (SO4) donated to other metabolic intermediates; and 3) aminopropylation, as S-Adenosyl-L-methionine plays an important role in the synthesis of polyamines which can eventually form and recycle methionine[2].
In vitro studies using human articular chondrocytes have shown S-Adenosyl-L-methionine-induced increases in proteoglycan synthesis and proliferation rates in rabbits[2].

In Vivo

Mice lacking methionine adenosyltransferase 1a (Mat1a) have reduced hepatic S-Adenosyl-L-methionine levels and develop oxidative stress, steatohepatitis, and hepatocellular carcinoma (HCC). However, injury and HCC also occur if hepatic S-Adenosyl-L-methionine level is excessive chronically. Thus a normal hepatic S-Adenosyl-L-methionine level is necessary to maintain liver health and prevent injury and HCC[3].

Clinical Trial
Molecular Weight

398.44

Formula

C₁₅H₂₂N₆O₅S

CAS No.

29908-03-0

SMILES

O[[email protected]@H]([[email protected]]([[email protected]](N1C=NC2=C1N=CN=C2N)O3)O)[[email protected]]3C[S+](CC[[email protected]](N)C([O-])=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (250.98 mM; Need ultrasonic)

H2O : ≥ 43 mg/mL (107.92 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5098 mL 12.5489 mL 25.0979 mL
5 mM 0.5020 mL 2.5098 mL 5.0196 mL
10 mM 0.2510 mL 1.2549 mL 2.5098 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

S-Adenosyl-L-methionineS-Adenosyl methionineAdemetionineAdoMetEndogenous MetaboliteATPmethioninedietarysupplementadenosyltransferasemethyl antidepressantanalgesicosteoarthritisliverInhibitorinhibitorinhibit

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S-Adenosyl-L-methionine
Cat. No.:
HY-B0617
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