1. Metabolic Enzyme/Protease Apoptosis
  2. Endogenous Metabolite Apoptosis
  3. S-Adenosyl-L-methionine

S-Adenosyl-L-methionine  (Synonyms: S-Adenosyl methionine; Ademetionine; AdoMet)

Cat. No.: HY-B0617
COA Handling Instructions

S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (S-Adenosyl-L-methionine disulfate tosylate) that retains the same biological activity.

For research use only. We do not sell to patients.

S-Adenosyl-L-methionine Chemical Structure

S-Adenosyl-L-methionine Chemical Structure

CAS No. : 29908-03-0

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Top Publications Citing Use of Products

    S-Adenosyl-L-methionine purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2021 Mar 22;95:107545.  [Abstract]

    S-adenosylmethionine (SAMe) application at 30 min prior to high glucose treatment significantly increased H2S levels compared with the HG group. The cystathionine-β-synthase (CBS) level is obviously elevated in HG + SAMe group compared with the HG group.
    • Biological Activity

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    Description

    S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research[1][2][3].

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    S-Adenosyl-L-methionine (300 µM, 24 or 48 h) induces cell apoptosis, and promotes the cell cycle arrest in Cal-33 and JHU-SCC-011 cells[4].
    S-Adenosyl-L-methionine (300 µM, 24 h) decreases the migration of the Cal-33 and JHU-SCC-011 cells[4].
    S-Adenosyl-L-methionine (5-40 μg/mL, 48 h) protects the anticancer effect of 5‑FU by regulating the expression of DNMTs[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Apoptosis Analysis[4]

    Cell Line: Cal-33 and JHU-SCC-011 cells
    Concentration: 300 µM
    Incubation Time: 24 h (Cal-33) or 48 h (HU-SCC-011)
    Result: Showed an approximately 10% and 3%of apoptotic cells respectively.

    Cell Cycle Analysis[4]

    Cell Line: Cal-33 and JHU-SCC-011 cells
    Concentration: 300 µM
    Incubation Time: 24 h (Cal-33) or 48 h (HU-SCC-011)
    Result: Decreased the expression of cyclin B1, E1 and D1 in the Cal-33 and JHU-SCC-011 cells.
    In Vivo

    S-Adenosyl-L-methionine (30 mg/kg, p.o., for 3 days) prevents ASD like behaviors induced by early postnatal valproic acid exposure in young mice[6].
    S-Adenosyl-L-methionine (50 and 100 mg/kg, p.o.) shows antiepileptic, memory-enhancing, and antioxidant properties in a Pentylenetetrazole-induced rat epilepsy model[7].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Valproic acid treated young mice[6]
    Dosage: 30 mg/kg
    Administration: p.o., for 3 days
    Result: Alleviated most ASD like neurobehavioral symptoms.
    Normalized the redox potential in the prefrontal cortex.
    Clinical Trial
    Molecular Weight

    398.44

    Formula

    C15H22N6O5S

    CAS No.
    Appearance

    Solid

    Color

    Off-white to light yellow

    SMILES

    O[C@H]1[C@](O[C@@H]([C@H]1O)C[S+](C)CC[C@H](N)C([O-])=O)([H])N2C3=NC=NC(N)=C3N=C2

    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (250.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : ≥ 43 mg/mL (107.92 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.5098 mL 12.5489 mL 25.0979 mL
    5 mM 0.5020 mL 2.5098 mL 5.0196 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: ≥98.0%

    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 2.5098 mL 12.5489 mL 25.0979 mL 62.7447 mL
    5 mM 0.5020 mL 2.5098 mL 5.0196 mL 12.5489 mL
    10 mM 0.2510 mL 1.2549 mL 2.5098 mL 6.2745 mL
    15 mM 0.1673 mL 0.8366 mL 1.6732 mL 4.1830 mL
    20 mM 0.1255 mL 0.6274 mL 1.2549 mL 3.1372 mL
    25 mM 0.1004 mL 0.5020 mL 1.0039 mL 2.5098 mL
    30 mM 0.0837 mL 0.4183 mL 0.8366 mL 2.0915 mL
    40 mM 0.0627 mL 0.3137 mL 0.6274 mL 1.5686 mL
    50 mM 0.0502 mL 0.2510 mL 0.5020 mL 1.2549 mL
    60 mM 0.0418 mL 0.2091 mL 0.4183 mL 1.0457 mL
    80 mM 0.0314 mL 0.1569 mL 0.3137 mL 0.7843 mL
    100 mM 0.0251 mL 0.1255 mL 0.2510 mL 0.6274 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
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