1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. S-Adenosyl-L-methionine

S-Adenosyl-L-methionine (Synonyms: S-Adenosyl methionine; Ademetionine; AdoMet)

Cat. No.: HY-B0617
Handling Instructions

S-Adenosyl-L-methionine (S-Adenosyl methionine) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects, and has the potential for liver disease and osteoarthritis research.

For research use only. We do not sell to patients.

S-Adenosyl-L-methionine Chemical Structure

S-Adenosyl-L-methionine Chemical Structure

CAS No. : 29908-03-0

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Top Publications Citing Use of Products

    S-Adenosyl-L-methionine purchased from MCE. Usage Cited in: Int Immunopharmacol. 2021 Mar 22;95:107545.

    S-adenosylmethionine (SAMe) application at 30 min prior to high glucose treatment significantly increased H2S levels compared with the HG group. The cystathionine-β-synthase (CBS) level is obviously elevated in HG + SAMe group compared with the HG group.
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    Description

    S-Adenosyl-L-methionine (S-Adenosyl methionine) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects, and has the potential for liver disease and osteoarthritis research[1][2][3].

    In Vitro

    S-Adenosyl-L-methionine (Ademetionine) is involved in three main metabolic pathways: 1) methylation, as the principal source of methyl groups in the body; 2) transsulfuration, S-Adenosyl-L-methionine forms S-Adenosylhomocysteine (SAH) and then converted to homocysteine (Hcy) which can be converted to cystathionine then to cysteine and the sulfate (SO4) donated to other metabolic intermediates; and 3) aminopropylation, as S-Adenosyl-L-methionine plays an important role in the synthesis of polyamines which can eventually form and recycle methionine[2].
    In vitro studies using human articular chondrocytes have shown S-Adenosyl-L-methionine-induced increases in proteoglycan synthesis and proliferation rates in rabbits[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Mice lacking methionine adenosyltransferase 1a (Mat1a) have reduced hepatic S-Adenosyl-L-methionine levels and develop oxidative stress, steatohepatitis, and hepatocellular carcinoma (HCC). However, injury and HCC also occur if hepatic S-Adenosyl-L-methionine level is excessive chronically. Thus a normal hepatic S-Adenosyl-L-methionine level is necessary to maintain liver health and prevent injury and HCC[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    398.44

    Formula

    C₁₅H₂₂N₆O₅S

    CAS No.
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (250.98 mM; Need ultrasonic)

    H2O : ≥ 43 mg/mL (107.92 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.5098 mL 12.5489 mL 25.0979 mL
    5 mM 0.5020 mL 2.5098 mL 5.0196 mL
    10 mM 0.2510 mL 1.2549 mL 2.5098 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References

    Purity: ≥98.0%

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    Product Name:
    S-Adenosyl-L-methionine
    Cat. No.:
    HY-B0617
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