Cat. No.: HY-B0617B

S-Adenosyl-L-methionine 1,4-butanedisulfonate

Name: S-Adenosyl-L-methionine 1,4-butanedisulfonate
Brand: MedChemExpress
SKU: HY-B0617B
Availability: PreOrder

(Synonyms: S-Adenosyl methionine 1,4-butanedisulfonate; Ademetionine 1,4-butanedisulfonate; AdoMet 1,4-butanedisulfonate)

18 Cited Publications

Customer Review

Based on 18 publication(s) in Google Scholar

S-Adenosyl-L-methionine (S-Adenosyl methionine) 1,4-butanedisulfonate is an orally active methyl group donor. S-Adenosyl-L-methionine 1,4-butanedisulfonate is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine 1,4-butanedisulfonate also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine 1,4-butanedisulfonate has the potential for, cancer, liver disease and osteoarthritis research.

For research use only. We do not sell to patients.

CAS No.: 200393-05-1
Formula: C₁₉H₃₂N₆O₁₁S₃
Molecular Weight:616.69

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (281 KB)

S-Adenosyl-L-methionine 1,4-butanedisulfonate Chemical Structure

CAS No.: 200393-05-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (18)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Endogenous Metabolite Isoforms :

In Vitro

S-Adenosyl-L-methionine (300 µM, 24 or 48 h) 1,4-butanedisulfonate induces cell apoptosis, and promotes the cell cycle arrest in Cal-33 and JHU-SCC-011 cells^[4].
S-Adenosyl-L-methionine (300 µM, 24 h) 1,4-butanedisulfonate decreases the migration of the Cal-33 and JHU-SCC-011 cells^[4].
S-Adenosyl-L-methionine (5-40 μg/mL, 48 h) 1,4-butanedisulfonate protects the anticancer effect of 5‑FU by regulating the expression of DNMTs^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[4]

Cell Line:

Cal-33 and JHU-SCC-011 cells
Concentration:

300 µM
Incubation Time:

24 h (Cal-33) or 48 h (HU-SCC-011)
Result:

Showed an approximately 10% and 3%of apoptotic cells respectively.

Cell Cycle Analysis^[4]

Cell Line:

Cal-33 and JHU-SCC-011 cells
Concentration:

300 µM
Incubation Time:

24 h (Cal-33) or 48 h (HU-SCC-011)
Result:

Decreased the expression of cyclin B1, E1 and D1 in the Cal-33 and JHU-SCC-011 cells.

In Vivo

S-Adenosyl-L-methionine (30 mg/kg, p.o., for 3 days) 1,4-butanedisulfonate prevents ASD like behaviors induced by early postnatal valproic acid exposure in young mice^[6].
S-Adenosyl-L-methionine (50 and 100 mg/kg, p.o.) 1,4-butanedisulfonate shows antiepileptic, memory-enhancing, and antioxidant properties in a Pentylenetetrazole-induced rat epilepsy model^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Valproic acid treated young mice^[6]
Dosage:

30 mg/kg
Administration:

p.o., for 3 days
Result:

Alleviated most ASD like neurobehavioral symptoms.
Normalized the redox potential in the prefrontal cortex.

Chemical Information

CAS No. 200393-05-1
Molecular Weight 616.69
Formula C₁₉H₃₂N₆O₁₁S₃
SMILES

O=S(CCCCS(=O)(O)=O)(O)=O.O[C@H]1[C@@H](O[C@@H]([C@H]1O)C[S+](C)CC[C@H](N)C([O-])=O)N2C3=NC=NC(N)=C3N=C2
Synonyms

S-Adenosyl methionine 1,4-butanedisulfonate; Ademetionine 1,4-butanedisulfonate; AdoMet 1,4-butanedisulfonate
Structure Classification
- Others
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (18)

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Journal Impact Factor

Mol Cancer

ZNF526 drives tumor growth by enhancing SHMT1-dependent serine metabolism and antioxidant capability in TNBC. [Abstract]

2025 Nov 20;24(1):295. PMID: 41267037
Nat Commun

Nuclear localization of MTHFD2 is required for correct mitosis progression. [Abstract]

2024 Nov 12;15(1):9529. PMID: 39532843
Gut Microbes

Gut microbiota-mediated betaine regulates skeletal muscle fiber type transition by affecting m6A RNA methylation and Myh7 expression. [Abstract]

2025 Dec;17(1):2545434. PMID: 40824213
Environ Sci Technol

Arsenic Exposure Triggers Nonalcoholic Fatty Liver Disease through Repressing S-Adenosylmethionine-Dependent Histone Methylation in Rats. [Abstract]

2025 Jan 14;59(1):268-278. PMID: 39746780
J Exp Med

Adenosine metabolic clearance maintains liver homeostasis by licensing arginine methylation of RIPK1. [Abstract]

2026 Jan 5;223(1):e20250603. PMID: 41081715
J Agric Food Chem

Sesamol Epigenetically Induces Estrogen Receptor α Re-expression by Upregulating miR-370-3p in Estrogen Receptor α-Negative Breast Cancer. [Abstract]

2021 Aug 11;69(31):8737-8746. PMID: 34325508
Biochem Pharmacol

S-adenosylmethionine attenuates angiotensin II-induced aortic dissection formation by inhibiting vascular smooth muscle cell phenotypic switch and autophagy. [Abstract]

2024 Jan:219:115967. PMID: 38065291
Ind Crops Prod

2025 Dec 2;238:122414.
Plant J

Transcriptomic and metabolomic analyses unveil TaASMT3-mediated wheat resistance against stripe rust by promoting melatonin biosynthesis. [Abstract]

2025 Apr;122(2):e70182. PMID: 40298361
Int Immunopharmacol

Hydrogen sulfide ameliorates high glucose-induced pro-inflammation factors in HT-22 cells: Involvement of SIRT1-mTOR/NF-κB signaling pathway. [Abstract]

2021 Jun:95:107545. PMID: 33765609

S-Adenosyl-L-methionine 1,4-butanedisulfonate purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2021 Jun:95:107545. [Abstract]

S-adenosylmethionine (SAMe) application at 30 min prior to high glucose treatment significantly increased H2S levels compared with the HG group. The cystathionine-β-synthase (CBS) level is obviously elevated in HG + SAMe group compared with the HG group.
Epigenetics Chromatin

Ethionine-mediated reduction of S-adenosylmethionine is responsible for the neural tube defects in the developing mouse embryo-mediated m6A modification and is involved in neural tube defects via modulating Wnt/β-catenin signaling pathway. [Abstract]

2021 Dec 4;14(1):52. PMID: 34863249
J Pharm Biomed Anal

Quantitative determination of ademetionine in tablets utilizing ATR-FTIR and partial least squares methods approaches. [Abstract]

2024 Apr 15:241:115991. PMID: 38301577
SSRN

2026 Jun 23.
Biomed Pharmacother

Identification of nsp16 inhibitors of SARS -CoV-2, SARS -CoV-1 and MERS-CoV from FDA-approved drugs using in silico and in vitro methods. [Abstract]

2025 Aug:189:118246. PMID: 40543162
bioRxiv

2025 Jun 27.
bioRxiv

2023 Jun 1.
Research Square Preprint

2021 Jun.
Research Square Preprint

2020 Aug.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. G M Bressa. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14. [Content Brief]

[2]. Wadie I Najm, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 26;5:6. [Content Brief]

[3]. Shelly C Lu, et al. S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev. 2012 Oct;92(4):1515-42. [Content Brief]

[4]. Mosca L, et al. Effects of S‑adenosyl‑L‑methionine on the invasion and migration of head and neck squamous cancer cells and analysis of the underlying mechanisms. Int J Oncol. 2020 May;56(5):1212-1224. [Content Brief]

[5]. Ham MS, et al. S-adenosyl methionine specifically protects the anticancer effect of 5-FU via DNMTs expression in human A549 lung cancer cells. Mol Clin Oncol. 2013 Mar;1(2):373-378. [Content Brief]

[6]. Ornoy A, et al. S-adenosyl methionine prevents ASD like behaviors triggered by early postnatal valproic acid exposure in very young mice. Neurotoxicol Teratol. 2019 Jan-Feb;71:64-74. [Content Brief]

[7]. Dhediya RM, et al. Evaluation of antiepileptic effect of S-adenosyl methionine and its role in memory impairment in pentylenetetrazole-induced kindling model in rats. Epilepsy Behav. 2016 Aug;61:153-157. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

S-Adenosyl-L-methionine 1,4-butanedisulfonate

18 Cited Publications

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S-Adenosyl-L-methionine 1,4-butanedisulfonate

Publications Citing Use of MedChemExpress (MCE) S-Adenosyl-L-methionine 1,4-butanedisulfonate

All Endogenous Metabolite Isoforms