S-Adenosyl-L-methionine-¹³C dihydrochloride (Synonyms: S-Adenosyl methionine-13C dihydrochloride; Ademetionine-13C dihydrochloride; AdoMet-13C dihydrochloride)

Cat. No.: HY-B0617S2: Data Sheet
SDS
Handling Instructions
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S-Adenosyl-L-methionine-¹³C (S-Adenosyl methionine-¹³C) dihydrochloride is the ¹³C labeled S-Adenosyl-L-methionine (HY-B0617). S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research.

For research use only. We do not sell to patients.

S-Adenosyl-L-methionine-<sup>13</sup>C dihydrochloride

S-Adenosyl-L-methionine-¹³C dihydrochloride Chemical Structure

Size	Price	Stock
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution		Ask For Quote & Lead Time
Solution
10 mM * 1 mL in Water		Ask For Quote & Lead Time
Solid
1 mg		Ask For Quote & Lead Time
5 mg		Ask For Quote & Lead Time
10 mg		Ask For Quote & Lead Time
20 mg		Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of S-Adenosyl-L-methionine-¹³C dihydrochloride:

S-Adenosyl-L-methionine-¹³C

Other Forms of S-Adenosyl-L-methionine-¹³C dihydrochloride:

S-Adenosyl-L-methionine In-stock
S-Adenosyl-L-methionine-¹³C In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

508.81

Formula

C₁₄¹³CH₂₅Cl₃N₆O₅S

Unlabeled CAS

29908-03-0

Appearance

Solid

Color

Off-white to light yellow

SMILES

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](C[S+]([13CH3])CC[C@H](N)C(O)=O)O3.[Cl-].Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (98.27 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9654 mL	9.8269 mL	19.6537 mL
5 mM	0.3931 mL	1.9654 mL	3.9307 mL
10 mM	0.1965 mL	0.9827 mL	1.9654 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Data Sheet (276 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. G M Bressa. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14. [Content Brief]

[2]. Wadie I Najm, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 26;5:6. [Content Brief]

[3]. Shelly C Lu, et al. S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev. 2012 Oct;92(4):1515-42. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.9654 mL	9.8269 mL	19.6537 mL	49.1343 mL
	5 mM	0.3931 mL	1.9654 mL	3.9307 mL	9.8269 mL
	10 mM	0.1965 mL	0.9827 mL	1.9654 mL	4.9134 mL
	15 mM	0.1310 mL	0.6551 mL	1.3102 mL	3.2756 mL
	20 mM	0.0983 mL	0.4913 mL	0.9827 mL	2.4567 mL
	25 mM	0.0786 mL	0.3931 mL	0.7861 mL	1.9654 mL
	30 mM	0.0655 mL	0.3276 mL	0.6551 mL	1.6378 mL
	40 mM	0.0491 mL	0.2457 mL	0.4913 mL	1.2284 mL
	50 mM	0.0393 mL	0.1965 mL	0.3931 mL	0.9827 mL
	60 mM	0.0328 mL	0.1638 mL	0.3276 mL	0.8189 mL
	80 mM	0.0246 mL	0.1228 mL	0.2457 mL	0.6142 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

S-Adenosyl-L-methionine-¹³C dihydrochloride Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S-Adenosyl-L-methionine-¹³CS-Adenosyl methionine-13CAdemetionine-13CAdoMet-13CIsotope-Labeled CompoundsEndogenous MetaboliteApoptosisInhibitorinhibitorinhibit

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S-Adenosyl-L-methionine-13C dihydrochloride (Synonyms: S-Adenosyl methionine-13C dihydrochloride; Ademetionine-13C dihydrochloride; AdoMet-13C dihydrochloride)

Other Forms of S-Adenosyl-L-methionine-13C dihydrochloride:

S-Adenosyl-L-methionine-13C dihydrochloride Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Endogenous Metabolite Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

S-Adenosyl-L-methionine-13C dihydrochloride Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

S-Adenosyl-L-methionine-13C dihydrochloride Related Classifications