1. Epigenetics
    Anti-infection
  2. Histone Methyltransferase
    Fungal
    Antibiotic
  3. Sinefungin

Sinefungin (Synonyms: Adenosyl-Ornithine; A-9145; Antibiotic 32232RP)

Cat. No.: HY-101938 Purity: >99.0%
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Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin, a SET7/9 inhibitor, ameliorates renal fibrosis by inhibiting H3K4 methylation.

For research use only. We do not sell to patients.

Sinefungin Chemical Structure

Sinefungin Chemical Structure

CAS No. : 58944-73-3

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1 mg USD 300 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication[1]. Sinefungin, a SET7/9 inhibitor, ameliorates renal fibrosis by inhibiting H3K4 methylation[2].

In Vitro

Sinefungin (0.5 or 1.0 μg/mL, 60 minutes) ameliorates the TGF-β1-induced increase of α-SMA and inhibits the upregulation of histone H3K4 monomethylation in renal epithelial cells and renal fibroblast cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: Renal epithelial cells.
Concentration: 0.5 or 1.0 μg/mL.
Incubation Time: Pretreatment 60 minutes before TGF-β1 (10 ng/mL).
Result: Significantly reduced TGF-β1-inducedα-SMA protein expression and inhibited H3K4me1 in a dose-dependent manner in both NRK-52E and NRK-49F cells.
In Vivo

Sinefungin (10 mg/kg, per day immediately after UUO) ameliorates renal fibrosis in obstructive nephropathy[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice (8 weeks of age)[2].
Dosage: 10 mg/kg
Administration: Administered intraperitoneally per day immediately after UUO (prepared as a suspension in distilled water and 0.9% NaCl solution).
Result: Inhibited α-SMA protein expression.
Ameliorated those (α-SMA, FSP-1, collagen 1, collagen 3) both at 3 and 7 days after UUO.
Molecular Weight

381.39

Formula

C₁₅H₂₃N₇O₅

CAS No.

58944-73-3

SMILES
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Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (262.20 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6220 mL 13.1099 mL 26.2199 mL
5 mM 0.5244 mL 2.6220 mL 5.2440 mL
10 mM 0.2622 mL 1.3110 mL 2.6220 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >99.0%

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Keywords:

SinefunginAdenosyl-Ornithine A-9145 Antibiotic 32232RPA9145A 9145A-9145Histone MethyltransferaseFungalAntibioticUUPα-SMAFSP-1collagen 1collagen 3H3K4Inhibitorinhibitorinhibit

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