58944-73-3
Chemical Structure
Sinefungin
Synonym(s): Adenosyl-Ornithine; A-9145; Antibiotic 32232RP
- CAS No.: 58944-73-3
- Formula:C15H23N7O5
- Molecular Weight:381.39
IUPAC Name: (2S,5S)-2,5-diamino-6-((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)hexanoic acid
InChIKey: LMXOHSDXUQEUSF-YECHIGJVSA-N
SMILES: O[C@H]([C@@H]1O)[C@@H](O[C@@H]1C[C@@H](N)CC[C@H](N)C(O)=O)N2C(N=CN=C3N)=C3N=C2
Biological Activity: Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication[1]. Sinefungin, a SET7/9 inhibitor, ameliorates renal fibrosis by inhibiting H3K4 methylation[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Sinefungin | 98.00% | Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin, a SET7/9 inhibitor, ameliorates renal fibrosis by inhibiting H3K4 methylation. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Sinefungin (Standard) | ≥98% | Sinefungin (Standard) is the analytical standard of Sinefungin (HY-101938). This product is intended for research and analytical applications. Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin, a SET7/9 inhibitor, ameliorates renal fibrosis by inhibiting H3K4 methylation. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.84
HY-124699MMSET-IN-1 -
Similarity Score 0.79
HY-19528SAH -
Similarity Score 0.79
HY-19528S2SAH-13C10 -
Similarity Score 0.79
HY-W423489SARS-CoV-2-IN-76 -
Similarity Score 0.77
HY-14614DS-Adenosyl-L-methionine iodide -
Similarity Score 0.77
HY-111592S-(5′-Adenosyl)-L-cysteine -
Similarity Score 0.77
HY-157719S-Adenosylhomocysteine sulfoxide -
Similarity Score 0.76
HY-14614AS-Adenosyl-L-methionine chloride dihydrochloride -
Similarity Score 0.75
HY-137802SAHO2 -
Explore the MedChemAI to find more analogs
References
- [1]. Pugh CS, et al. Sinefungin, a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. J Biol Chem. 1978 Jun 25;253(12):4075-7. [Content Brief]
- [2]. Sasaki K, et al. Inhibition of SET Domain-Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis. J Am Soc Nephrol. 2016 Jan;27(1):203-15. [Content Brief]
