CD1B-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His)

CD1B belongs to family 1 of the transmembrane glycoprotein CD1 family and plays a critical role in immune surveillance and response. As a key antigen-presenting molecule, CD1B protein has shown the ability to bind both self and non-self-lipid and glycolipid antigens. CD1B is a potential prognostic biomarker associated with tumor mutation burden and promotes antitumor immunity in lung adenocarcinoma. CD1B-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His) is a recombinant protein dimer complex containing Rhesus Macaque-derived CD1B-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. CD1B-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His), has molecular weight of ~38-45 & 12 KDa.

CD1B belongs to Group 1 of the transmembrane glycoprotein CD1 family. The CD1 molecule is expressed on the surface of many different human antigen-presenting cells (DC, monocytes, and some thymus cells). The CD1B protein, as a key antigen-presenting molecule, has shown the ability to bind both self and non-self lipid and glycolipid antigens, thereby facilitating their presentation to T cell receptors on natural killer T cells. This protein forms a heterodimer complex with B2M (beta-2 microglobulin), which plays a crucial role in immune surveillance and response. Its interaction with saponin C further enhances its functional library, helping T cells to recognize and activate the complex process of various antigens. CD1B is a potential prognostic biomarker associated with tumor mutation burden and promotes antitumor immunity in lung adenocarcinoma^[1][2][3].

Measured by its binding ability in a functional ELISA. Immobilized Rhesus Macaque CD1B-B2M Heterodimer at 2 μg/mL (100 μL/well) can bind Anti-CD1B Antibody, The ED₅₀ for this effect is 1.538 μg/mL .

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  Measured by its binding ability in a functional ELISA. Immobilized Rhesus Macaque CD1B-B2M Heterodimer at 2 μg/mL (100 μL/well) can bind Anti-CD1B Antibody, The ED₅₀ for this effect is 1.538 μg/mL .

Rhesus Macaque

HEK293

C-6*His

NP_001139006 (E19-S303)&NP_001040602 (I21-M119)

718955  [NCBI]&712428  [NCBI]

Approximately 38-45 & 12 kDa due to the glycosylation.

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  ≥ 95%, as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.