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2,2′-Dipyridyl disulfide 

Cat. No.: HY-Y1666 Purity: 99.42%
Handling Instructions

2,2′-Dipyridyl disulfide is a useful reagent for the determination of sulfhydryl groups. 2,2′-Dipyridyl disulfide is a common reagent in peptide chemistry, often used in oxidation–reduction condensations to form peptide bonds or in coupling reactions to form disulfide-linked heterodimers.

For research use only. We do not sell to patients.

2,2′-Dipyridyl disulfide Chemical Structure

2,2′-Dipyridyl disulfide Chemical Structure

CAS No. : 2127-03-9

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Based on 1 publication(s) in Google Scholar

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Description

2,2′-Dipyridyl disulfide is a useful reagent for the determination of sulfhydryl groups. 2,2′-Dipyridyl disulfide is a common reagent in peptide chemistry, often used in oxidation–reduction condensations to form peptide bonds or in coupling reactions to form disulfide-linked heterodimers[1].

In Vitro

Formation of intramolecular S–S bonds can be dramatically accelerated by addition of a 2,2′-Dipyridyl disulfide (2-PDS) solution to an air-oxidized mixture of cysteine-containing peptides[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

220.31

Formula

C₁₀H₈N₂S₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (453.91 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5391 mL 22.6953 mL 45.3906 mL
5 mM 0.9078 mL 4.5391 mL 9.0781 mL
10 mM 0.4539 mL 2.2695 mL 4.5391 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (11.35 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (11.35 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (11.35 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.42%

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Product Name:
2,2′-Dipyridyl disulfide
Cat. No.:
HY-Y1666
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