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CD1C-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His)

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Based on 1 Customer Validation

CD1C belongs to Group 1 of the transmembrane glycoprotein CD1 family. CD1C protein, as a key antigen-presenting molecule, has shown the ability to bind both self and non-self lipid and glycolipid antigens, mediating host defense against tuberculosis. CD1C is associated with breast cancer prognosis and immune invasion. CD1C-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His) is a recombinant protein dimer complex containing Rhesus Macaque-derived CD1C-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. CD1C-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His), has molecular weight of ~44.7 (33.1+ 11.6) KDa.

For research use only. We do not sell to patients.
  • Species: Rhesus Macaque
  • Source: HEK293
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
  • Experimental Validation Results for CD1C-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His)
  • Experimental Validation Results for CD1C-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His)
  • CD1C-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His) Product Image
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To place orders, for customer services and technical support, please contact:

609-228-6898
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
  • Help & FAQs
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Biological Activity

Description

CD1C belongs to Group 1 of the transmembrane glycoprotein CD1 family. CD1C protein, as a key antigen-presenting molecule, has shown the ability to bind both self and non-self lipid and glycolipid antigens, mediating host defense against tuberculosis. CD1C is associated with breast cancer prognosis and immune invasion. CD1C-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His) is a recombinant protein dimer complex containing Rhesus Macaque-derived CD1C-B2M Heterodimer protein, expressed by HEK293 , with C-His labeled tag. CD1C-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His), has molecular weight of ~44.7 (33.1+ 11.6) KDa.

Background

CD1C belongs to Group 1 of the transmembrane glycoprotein CD1 family. The CD1 molecule is expressed on the surface of many different human antigen-presenting cells (DC, monocytes, and some thymus cells). The CD1C protein, as a key antigen-presenting molecule, has shown the ability to bind both self and non-self lipid and glycolipid antigens, thereby facilitating their presentation to T cell receptors on natural killer T cells. Human group 1 CD1 molecules (CD1a, CD1b, and CD1c) bind to pools of lipid antigens expressed by mycobacteria and present them to specific T cells, thereby mediating an effective pathway for host defense against tuberculosis. CD1C is associated with breast cancer prognosis and immune invasion[1][2][3].

Verified Bioactivity

Measured by its binding ability in a functional ELISA. Immobilized Rhesus Macaque CD1C-B2M Heterodimer, at 2μg/mL (100μL/well) can bind Anti-CD1C antibody. The ED50 for this effect is 0.1125 μg/mL.

MCE Validation Data

  • Purity - SDS-PAGE

    Purity - SDS-PAGE

    ≥ 95%, as determined by reducing SDS-PAGE.

  • Bioactivity - ELISA

    Bioactivity - ELISA

    Measured by its binding ability in a functional ELISA. Immobilized Rhesus Macaque CD1C-B2M Heterodimer, at 2 μg/mL (100 μL/well) can bind Anti-CD1C antibody. The ED50 for this effect is 0.1125 μg/mL.

Technical Parameters

  • Species Rhesus Macaque
  • Source HEK293
  • Tag C-6*His
  • Accession

    NP_001139005 (Q21-F298)&NP_001040602 (I21-M119)

  • Gene ID
    717148  [NCBI]&712428  [NCBI]
  • Synonyms

    CD1C; CD1c Antigen; Prev. CD1; BDCA1; T-Cell Surface Glycoprotein CD1c; R7; CD1C Antigen, C Polypeptide; CD1c Molecule; Cortical Thymocyte Antigen CD1C; B2M; Beta 2-Microglobulin; Beta-2-Microglobulin; Beta-2-Microglobin; Beta Chain Of MHC Class I Molecul

  • Molecular Weight

    Approximately 38 & 12 kDa.

  • Purity

    ≥ 95%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

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Dilution Calculator

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedChemExpress Validation
     ≥ 95%, as determined by reducing SDS-PAGE.

  • 1/16

    MedChemExpress Validation
     Measured by its binding ability in a functional ELISA. Immobilized Rhesus Macaque CD1C-B2M Heterodimer, at 2 μg/mL (100 μL/well) can bind Anti-CD1C antibody. The ED50 for this effect is 0.1125 μg/mL.

  • CD1C-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His) Product Image
    1/16
  • Experimental Validation Results for CD1C-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His)
  • Experimental Validation Results for CD1C-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His)
  • CD1C-B2M Heterodimer Protein, Rhesus Macaque (HEK293, His) Product Image