SN52
Based on 5 publication(s) in Google Scholar
SN52 is a potent, competitive, and cell-permeable inhibitor of NF-κB2. SN52 is a variant of the SN50 peptide and inhibits the nuclear translocation of p52-RelB heterodimers. SN52 has a strong radiosensitization effect on prostate cancer cells. SN52 can be used for cancer research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.31%
- CAS 番号: 1071173-56-2
- 分子式: C128H230N38O28
- 分子量:2749.43
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保管条件:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Customer Validation & Images
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Cell Proliferation/Viability Assay
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Cell Imaging/Staining
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In Vivo Efficacy Study
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Cell Migration/Invasion Assay
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Flow Cytometry
生物活性
製品説明
IC50 & Target
IC50: NF-κB2[1]
体外実験
SN52 (40 μg/ml; 30 mins before DMXAA) inhibits DMXAA-induced nuclear translocation of RelB in BMDCs[1].SN52 does not change the activation of canonical NF-κB signaling. The nuclear translocation of RelB is increased in DCs isolated from irradiated tumors, and SN52 abolishes this activation in activated DC cells[1].SN52 (40 μg/mL; 30 mins before co-cultured with irradiated or non-irradiated MC38 cells) inhibits the non-canonical NF-κB and increases Ifn-b expression in BMDCs stimulated with irradiated tumor cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Tumor mice model[1]
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Dosage:40 μg
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Administration:Intrathecal injection; 40 μg; day-1, day 1 and day 3 of 20Gy radiation of radiation
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Result:Reduced tumor burden than IR group alone. Induced non-canonical NF-κB inhibition and potentiates the anti-tumor effect of IR.
化学情報
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CAS 番号 1071173-56-2
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性状 Solid
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分子量 2749.43
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分子式 C128H230N38O28
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Color White to off-white
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配列
Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Arg-Lys-Ala-Leu-Pro
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シーケンスの短縮
AAVALLPAVLLALLAPVQRKRRKALP
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (5)
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Journal Impact Factor
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Most Recent
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Cell Death Differ
RIPK3 sequentially recruits MLKL and RIPK1 to induce PANoptosis and chemokine production. [Abstract]2026 Apr 4. PMID: 41935203 -
Mol Biomed
The m6A reader IGF2BP2 promotes hepatocellular carcinoma progression via enhancing RELB stability. [Abstract]2026 May 7;7(1):62. PMID: 42096134
SN52 purchased from MedChemExpress. Usage Cited in: Mol Biomed. 2026 May 7;7(1):62. [Abstract]
The effect of SN52 (40 μg/ml, 48 h) in HCC cells with overexpression IGF2BP2 and knockdown IGF2BP2.
SN52 purchased from MedChemExpress. Usage Cited in: Mol Biomed. 2026 May 7;7(1):62. [Abstract]
The effect of SN52 on the nuclear translocation of the RELB:p52 dimer in HepG2 cells.
SN52 purchased from MedChemExpress. Usage Cited in: Mol Biomed. 2026 May 7;7(1):62. [Abstract]
The schematic of therapeutic role of SN52 (40 μg/mouse, ip) combined with IGF2BP2 inhibition was evaluated with subcutaneous xenograft implantation model. Images of subcutaneous tumor.
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Cell Signal
TET1 mediated m5C modification of RelB aggravates cerebral ischemia/reperfusion-induced neuroinflammation through regulating microglia polarization. [Abstract]2024 Aug:120:111210. PMID: 38705503 -
Cancer Med
RELB Overexpression Induced by DNA Hypomethylation Contributes to Perioperative Immunotherapy Resistance in Resectable Esophageal Squamous Cell Carcinoma by Modulating the mregDC-Treg Axis. [Abstract]2026 May;15(5):e71863. PMID: 42130013
SN52 purchased from MedChemExpress. Usage Cited in: Cancer Med. 2026 May;15(5):e71863. [Abstract]
Wound healing assays demonstrated that siRELB and SN52 significantly reduced the migration of ESCC cells compared with that of control cells.
SN52 purchased from MedChemExpress. Usage Cited in: Cancer Med. 2026 May;15(5):e71863. [Abstract]
Flow cytometric analysis revealed that siRELB and SN52 (40 μg/mL, 40 min) induced apoptosis in ESCC cells.
SN52 purchased from MedChemExpress. Usage Cited in: Cancer Med. 2026 May;15(5):e71863. [Abstract]
Colony formation assays indicated that siRELB and SN52 (40 μg/mL, 40 min) suppressed ESCC cell proliferation.
SN52 purchased from MedChemExpress. Usage Cited in: Cancer Med. 2026 May;15(5):e71863. [Abstract]
Western blot analysis confirmed that siRELB and SN52 (40 μg/mL, 40 min) decreased Bcl-2 expression and increased E‐cadherin and Bax expression.
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溶剤 & 溶解度
体外:
H2O : 25 mg/mL (9.09 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (18.19 mM); Clear solution; Need ultrasonic
純度とドキュメンテーション
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データシート (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Yong Xu, et al. SN52, a novel nuclear factor-kappaB inhibitor, blocks nuclear import of RelB:p52 dimer and sensitizes prostate cancer cells to ionizing radiation. Mol Cancer Ther [Content Brief]
[2]. Yuzhu Hou, et al. Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy. Immunity. 2018 Sep 18;49(3):490-503.e4 [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.3637 mL | 1.8186 mL | 3.6371 mL | 9.0928 mL |
| 5 mM | 0.0727 mL | 0.3637 mL | 0.7274 mL | 1.8186 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
SN52 関連分類
HY-P3229 関連分類
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