TWIK-1/TREK-1-IN-3
Based on 1 Customer Validation
TWIK-1/TREK-1-IN-3 (compound 2h) is an inhibitor of TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.74 μM and 16.5 μM, respectively, and has antidepressant-like effects.
For research use only. We do not sell to patients.
- Purity: 99.61%
- CAS No.: 1440532-33-1
- Formula: C19H27F3N2O2
- Molecular Weight:372.43
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 9.74 μM (TREK-1/TREK-1), 16.5 μM (TWIK-1/TREK-1)[1]
Chemical Information
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CAS No. 1440532-33-1
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Appearance Solid
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Molecular Weight 372.43
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Formula C19H27F3N2O2
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Color White to off-white
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SMILES
O[C@H](COC1=CC=C(C(F)(F)F)C=C1)CN2CCC(N3CCCC3)CC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (67.13 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6851 mL | 13.4253 mL | 26.8507 mL | 67.1267 mL |
| 5 mM | 0.5370 mL | 2.6851 mL | 5.3701 mL | 13.4253 mL | |
| 10 mM | 0.2685 mL | 1.3425 mL | 2.6851 mL | 6.7127 mL | |
| 15 mM | 0.1790 mL | 0.8950 mL | 1.7900 mL | 4.4751 mL | |
| 20 mM | 0.1343 mL | 0.6713 mL | 1.3425 mL | 3.3563 mL | |
| 25 mM | 0.1074 mL | 0.5370 mL | 1.0740 mL | 2.6851 mL | |
| 30 mM | 0.0895 mL | 0.4475 mL | 0.8950 mL | 2.2376 mL | |
| 40 mM | 0.0671 mL | 0.3356 mL | 0.6713 mL | 1.6782 mL | |
| 50 mM | 0.0537 mL | 0.2685 mL | 0.5370 mL | 1.3425 mL | |
| 60 mM | 0.0448 mL | 0.2238 mL | 0.4475 mL | 1.1188 mL |
TWIK-1/TREK-1-IN-3 Related Classifications
HY-149538 Related Classifications
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