2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. TWIK-1/TREK-1-IN-3

TWIK-1/TREK-1-IN-3 (compound 2h) is an inhibitor of TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.74 μM and 16.5 μM, respectively, and has antidepressant-like effects.

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TWIK-1/TREK-1-IN-3 Chemical Structure

TWIK-1/TREK-1-IN-3 Chemical Structure

CAS No. : 1440532-33-1

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Based on 1 publication(s) in Google Scholar

TWIK-1/TREK-1-IN-3 Related Antibodies

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Description

TWIK-1/TREK-1-IN-3 (compound 2h) is an inhibitor of TWIK-related potassium channel (Potassium Channel) TREK-1. TREK-1 contains a two-pore domain potassium (K2p) channel that dimerizes into TREK-1 homodimer and TWIK-1/TREK-1 heterodimer, and is an important antidepressant target. TWIK-1/TREK-1-IN-3 targets TREK-1 homodimer and TWIK-1/TREK-1 heterodimer with IC50s of 9.74 μM and 16.5 μM, respectively, and has antidepressant-like effects[1].

IC50 & Target

IC50: 9.74 μM (TREK-1/TREK-1), 16.5 μM (TWIK-1/TREK-1)[1]
Molecular Weight

372.43

Formula

C19H27F3N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H](COC1=CC=C(C(F)(F)F)C=C1)CN2CCC(N3CCCC3)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (67.13 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6851 mL 13.4253 mL 26.8507 mL
5 mM 0.5370 mL 2.6851 mL 5.3701 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6851 mL 13.4253 mL 26.8507 mL 67.1267 mL
5 mM 0.5370 mL 2.6851 mL 5.3701 mL 13.4253 mL
10 mM 0.2685 mL 1.3425 mL 2.6851 mL 6.7127 mL
15 mM 0.1790 mL 0.8950 mL 1.7900 mL 4.4751 mL
20 mM 0.1343 mL 0.6713 mL 1.3425 mL 3.3563 mL
25 mM 0.1074 mL 0.5370 mL 1.0740 mL 2.6851 mL
30 mM 0.0895 mL 0.4475 mL 0.8950 mL 2.2376 mL
40 mM 0.0671 mL 0.3356 mL 0.6713 mL 1.6782 mL
50 mM 0.0537 mL 0.2685 mL 0.5370 mL 1.3425 mL
60 mM 0.0448 mL 0.2238 mL 0.4475 mL 1.1188 mL
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TWIK-1/TREK-1-IN-3 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TWIK-1/TREK-1-IN-31440532-33-1Potassium ChannelKcsAAntidepressantAstrocytesDepressive-like behaviorFluoxetineTREK-1TWIK-1Inhibitorinhibitorinhibit

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