Copy Link Print Information

Irinotecan hydrochloride trihydrate

(Synonyms: (+)-Irinotecan hydrochloride trihydrate; CPT-11 hydrochloride trihydrate)
81 Cited Publications
Avis client

Based on 81 publication(s) in Google Scholar

Irinotecan hydrochloride trihydrate ((+)-Irinotecan hydrochloride trihydrate) is a topoisomerase I inhibitor with antitumor activity.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

  • Pureté: 99.89%
  • CAS No.: 136572-09-3
  • Formule: C33H45ClN4O9
  • Masse moléculaire:677.18
  • Stockage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Irinotecan hydrochloride trihydrate Chemical Structure
    Irinotecan hydrochloride trihydrate Chemical Structure
  • Experimental Validation Results for Irinotecan hydrochloride trihydrate
  • Experimental Validation Results for Irinotecan hydrochloride trihydrate
  • Experimental Validation Results for Irinotecan hydrochloride trihydrate
  • Experimental Validation Results for Irinotecan hydrochloride trihydrate
  • Experimental Validation Results for Irinotecan hydrochloride trihydrate
  • Experimental Validation Results for Irinotecan hydrochloride trihydrate
  • Experimental Validation Results for Irinotecan hydrochloride trihydrate
  • Experimental Validation Results for Irinotecan hydrochloride trihydrate
  • Experimental Validation Results for Irinotecan hydrochloride trihydrate
  • Experimental Validation Results for Irinotecan hydrochloride trihydrate
CAS No.: 136572-09-3
Size
Prix
Stock
Quantité
Amount: USD 0.00
Please select quantity
or
or

* Veuillez sélectionner la quantité avant d'ajouter des articles.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Other Forms of Irinotecan hydrochloride trihydrate:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
  • Activité biologique
  • Chemical Information
  • Solvant et solubilité
  • Protocole
  • Pureté et documentation
  • Références
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) Irinotecan hydrochloride trihydrate

More
Customer Validation & Images
Cell Proliferation/Viability AssayIn Vivo Efficacy StudyIHCWBCell Imaging/StainingIF
  • Cell Proliferation/Viability Assay
  • WB
  • IHC
  • In Vivo Efficacy Study
  • Cell Imaging/Staining
  • In Vivo Efficacy Study
  • IHC
  • IF
  • Cell Proliferation/Viability Assay
  • WB

Voir tous les produits spécifiques à Isoform Topoisomerase

More
Keywords
MOQ
Minimum order quantity
100 mg

Obtenir un devis En stock

Other size
Obtenir un devis
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Sign In
Enregistrer
Sign in to MedChemExpress
Enregistrer un nouveau compte

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • Irinotecan hydrochloride trihydrate Chemical Structure
    Irinotecan hydrochloride trihydrate Chemical Structure
    1/16
  • 1/16

    Irinotecan hydrochloride trihydrate purchased from MedChemExpress. Usage Cited in: Oncogene. 2025 Jun;44(22):1678-1693. [Abstract]

    Customer Validation
     Analysis of drug sensitivity in various SW480 and HCT116 cell lines after 48 h of treatment with with Irinotecan (1 μmol/L).

  • 1/16

    Irinotecan hydrochloride trihydrate purchased from MedChemExpress. Usage Cited in: Oncogene. 2025 Jun;44(22):1678-1693. [Abstract]

    Customer Validation
     Irinotecan (1 μmol/L, 48 h). Western blotting assays on caspase-3 and cleaved caspase-3 in SW480-Con/CBX3 cells following chemotherapy.

  • 1/16

    Irinotecan hydrochloride trihydrate purchased from MedChemExpress. Usage Cited in: Oncogene. 2025 Jun;44(22):1678-1693. [Abstract]

    Customer Validation
     Irinotecan (50 mg/kg, twice a week, administered intraperitoneally). Immunohistochemical staining of tumor tissues with antibodies against Ki67, NRF2, and GPX2 (low-power view 100×, high-power view 400×, scale bar = 50 μm).

  • 1/16

    Irinotecan hydrochloride trihydrate purchased from MedChemExpress. Usage Cited in: Oncogene. 2025 Jun;44(22):1678-1693. [Abstract]

    Customer Validation
     Irinotecan (50 mg/kg, twice a week, administered intraperitoneally). Tumors were measured every two days, and the tumor volumes were calculated. The tumors were excised and weighed 34 days after injection, and representative images of tumors were displayed (bar = 10 mm).

  • 1/16

    Irinotecan hydrochloride trihydrate purchased from MedChemExpress. Usage Cited in: Oncogene. 2025 Jun;44(22):1678-1693. [Abstract]

    Customer Validation
     SW480-Con/CBX3 cells were treated with Irinotecan (1 μmol/L) for 8 h and stained with C11 BODIPY (oxidized lipid was stained green) and then detected by both flow cytometry and confocal microscopy. ERTracker Blue-White was used to detect the location of lipid oxidation by confocal microscopy (high-power view 400×, scale bar = 50 μm) (N = 3).

  • 1/16

    Irinotecan hydrochloride trihydrate purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2024 Apr;14(4):1677-1692. [Abstract]

    Customer Validation
     Irinotecan (25 mg/kg/day) were administered intraperitoneally from Day 0 to Day 4. Tumor volume in the control, CPT/5FU and E. copr groups were recorded daily.

  • 1/16

    Irinotecan hydrochloride trihydrate purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2024 Apr;14(4):1677-1692. [Abstract]

    Customer Validation
     Irinotecan (25 mg/kg/day) were administered intraperitoneally from Day 0 to Day 4. Expression of PCNA was measured by IHC and quantified by ImageJ in the tumor sections. Scale bar: 100 mm.

  • 1/16

    Irinotecan hydrochloride trihydrate purchased from MedChemExpress. Usage Cited in: J Pharm Pharmacol. 2023 Apr 7;75(4):523-532. [Abstract]

    Customer Validation
     Irinotecan (CPT11; 20 μM; 48 h) or Etoposide (VP16; 20 μM; 48 h) induces MDA-MB-231 cells cycle arrest significantly.

  • 1/16

    Irinotecan hydrochloride trihydrate purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2021 May 28;6(1):188. [Abstract]

    Customer Validation
     Irinotecan (10 μM; 0–4 days). Cystine promoted colon cancer resistance to oxaliplatin and irinotecan (CPT-11) in vitro.

  • 1/16

    Irinotecan hydrochloride trihydrate purchased from MedChemExpress. Usage Cited in: Apoptosis. 2016 Feb;21(2):130-42. [Abstract]

    Customer Validation
     (a) CPT-11 induces cell cycle arrest and apoptosis in RAW 264.7macrophages. a.Western blot analysis of cleaved caspase-3 and PARP levels. (b) CPT-11 induced cell cycle arrest and apoptosis in mouse peritoneal macrophages. Western blot analysis of cleaved caspase-3 and PARP levels in peritoneal macrophages isolated from vehicleand CPT-11-administered mice. (c) Caspase-3 inhibitor z-DEVD-fmk (ZD) attenuates CPT-11-induced loss of GATA6+ peritoneal macrophages in mice. Western blot analy

  • Irinotecan hydrochloride trihydrate