2. Antibody-Drug Conjugate/ADC Related
  3. ADC Payloads
  4. 7-MAD-MDCPT

7-MAD-MDCPT, a Camptothecin analog, is a toxin payload in antibody drug conjugates (ADCs).

For research use only. We do not sell to patients.

7-MAD-MDCPT

7-MAD-MDCPT Chemical Structure

CAS No. : 765871-81-6

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Other Forms of 7-MAD-MDCPT:

7-MAD-MDCPT Related Antibodies

Top Publications Citing Use of Products

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

7-MAD-MDCPT, a Camptothecin analog, is a toxin payload in antibody drug conjugates (ADCs)[1].

IC50 & Target[1]

Camptothecins

 

Cellular Effect
Cell Line Type Value Description References
DEL IC50
0.7 nM
Compound: 88
Cytotoxicity against human DEL cells assessed as inhibition of cell growth incubated for 4 days by CellTiter-Glo luminescent assay
Cytotoxicity against human DEL cells assessed as inhibition of cell growth incubated for 4 days by CellTiter-Glo luminescent assay
[PMID: 39068862]
In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

7-MAD-MDCPT Related Antibodies
Molecular Weight

421.40

Formula

C22H19N3O6
CAS No.
Appearance

Solid

Color

Yellow to brown

SMILES

NCC1=C2C(C(N3C2)=CC([C@](O)(C(OC4)=O)CC)=C4C3=O)=NC5=CC(OCO6)=C6C=C51
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (237.30 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3730 mL 11.8652 mL 23.7304 mL
5 mM 0.4746 mL 2.3730 mL 4.7461 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.85%

SDS (480 KB)

COA (257 KB) HNMR (470 KB) RP-HPLC (229 KB) LCMS (96 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3730 mL 11.8652 mL 23.7304 mL 59.3261 mL
5 mM 0.4746 mL 2.3730 mL 4.7461 mL 11.8652 mL
10 mM 0.2373 mL 1.1865 mL 2.3730 mL 5.9326 mL
15 mM 0.1582 mL 0.7910 mL 1.5820 mL 3.9551 mL
20 mM 0.1187 mL 0.5933 mL 1.1865 mL 2.9663 mL
25 mM 0.0949 mL 0.4746 mL 0.9492 mL 2.3730 mL
30 mM 0.0791 mL 0.3955 mL 0.7910 mL 1.9775 mL
40 mM 0.0593 mL 0.2966 mL 0.5933 mL 1.4832 mL
50 mM 0.0475 mL 0.2373 mL 0.4746 mL 1.1865 mL
60 mM 0.0396 mL 0.1978 mL 0.3955 mL 0.9888 mL
80 mM 0.0297 mL 0.1483 mL 0.2966 mL 0.7416 mL
100 mM 0.0237 mL 0.1187 mL 0.2373 mL 0.5933 mL
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7-MAD-MDCPT Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

7-MAD-MDCPT765871-81-6ADC PayloadsADC CytotoxinsInhibitorinhibitorinhibit

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