7-MAD-MDCPT
Based on 1 Customer Validation
7-MAD-MDCPT, a Camptothecin analog, is a toxin payload in antibody drug conjugates (ADCs).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.85%
- CAS. Nr.: 765871-81-6
- Formel: C22H19N3O6
- Molecular Weight:421.40
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Speicherung:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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Camptothecins |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DEL | IC50 |
0.7 nM
Compound: 88
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Cytotoxicity against human DEL cells assessed as inhibition of cell growth incubated for 4 days by CellTiter-Glo luminescent assay
Cytotoxicity against human DEL cells assessed as inhibition of cell growth incubated for 4 days by CellTiter-Glo luminescent assay
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[PMID: 39068862] |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 765871-81-6
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Appearance Solid
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Molecular Weight 421.40
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Formel C22H19N3O6
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Color Yellow to brown
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SMILES
NCC1=C2C(C(N3C2)=CC([C@](O)(C(OC4)=O)CC)=C4C3=O)=NC5=CC(OCO6)=C6C=C51
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Lösungsmittel & Löslichkeit
DMSO : ≥ 100 mg/mL (237.30 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (276 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3730 mL | 11.8652 mL | 23.7304 mL | 59.3261 mL |
| 5 mM | 0.4746 mL | 2.3730 mL | 4.7461 mL | 11.8652 mL | |
| 10 mM | 0.2373 mL | 1.1865 mL | 2.3730 mL | 5.9326 mL | |
| 15 mM | 0.1582 mL | 0.7910 mL | 1.5820 mL | 3.9551 mL | |
| 20 mM | 0.1187 mL | 0.5933 mL | 1.1865 mL | 2.9663 mL | |
| 25 mM | 0.0949 mL | 0.4746 mL | 0.9492 mL | 2.3730 mL | |
| 30 mM | 0.0791 mL | 0.3955 mL | 0.7910 mL | 1.9775 mL | |
| 40 mM | 0.0593 mL | 0.2966 mL | 0.5933 mL | 1.4832 mL | |
| 50 mM | 0.0475 mL | 0.2373 mL | 0.4746 mL | 1.1865 mL | |
| 60 mM | 0.0396 mL | 0.1978 mL | 0.3955 mL | 0.9888 mL | |
| 80 mM | 0.0297 mL | 0.1483 mL | 0.2966 mL | 0.7416 mL | |
| 100 mM | 0.0237 mL | 0.1187 mL | 0.2373 mL | 0.5933 mL |
7-MAD-MDCPT Related Classifications
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