Copy Link Print Information

Tigecycline hydrochloride

(Synonyms: GAR-936 hydrochloride)
43 Cited Publications
Customer Review

Based on 43 publication(s) in Google Scholar

Tigecycline hydrochloride (GAR-936 hydrochloride) is a broad-spectrum glycylcycline antibiotic. The mean inhibitory concentration (MIC) of Tigecycline for E. coli (MG1655 strain) is approximately 125 ng/mL. MIC50 and MIC90 are 1 and 2 mg/L for Acinetobacter baumannii (A. baumannii), respectively.

For research use only. We do not sell to patients.

  • Purity: 99.56%
  • CAS No.: 197654-04-9
  • Formula: C29H40ClN5O8
  • Molecular Weight:622.11
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Tigecycline hydrochloride Chemical Structure
    Tigecycline hydrochloride Chemical Structure
  • Experimental Validation Results for Tigecycline hydrochloride
  • Experimental Validation Results for Tigecycline hydrochloride
  • Experimental Validation Results for Tigecycline hydrochloride
  • Experimental Validation Results for Tigecycline hydrochloride
  • Experimental Validation Results for Tigecycline hydrochloride
  • Experimental Validation Results for Tigecycline hydrochloride
CAS No.: 197654-04-9
Size
Price
Stock
Quantity
Amount: USD 0.00
Please select quantity
or
or

* Please select Quantity before adding items.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Other Forms of Tigecycline hydrochloride:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Chemical Information
  • Purity & Documentation
  • References
  • Help & FAQs
You May Still Need
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) Tigecycline hydrochloride

More
Customer Validation & Images
Cell Proliferation/Viability AssayWBMicrobiological Assay
  • Cell Proliferation/Viability Assay
  • WB
  • Microbiological Assay
  • Microbiological Assay
  • Cell Proliferation/Viability Assay
  • Microbiological Assay

All Antibiotic Isoforms

More
Keywords
100 mg

Get Quote In-stock

Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress Sign In
Register
Sign in to MedChemExpress
Register New Account

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • Tigecycline hydrochloride Chemical Structure
    Tigecycline hydrochloride Chemical Structure
    1/16
  • 1/16

    Tigecycline hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Jun 28;15(1):5481. [Abstract]

    Customer Validation
     Cell viability of HEK293T cells in the presence of increasing concentrations of Tigecycline (0.1-100 μM; 72 h), as measured by CCK-8 assay. Error bars (standard deviation) were calculated from three different experimental units (n = 3 independent experiments), and data were presented as mean values +/− SD.

  • 1/16

    Tigecycline hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Jun 28;15(1):5481. [Abstract]

    Customer Validation
     De novo mitochondrial and cytoplasmic nascent protein synthesis were measured by L-AHA labeling, followed by visualization of Alexa Fluor 488 fluorescence signal conjugated to L-AHA by “click reaction”. The intensity of the corresponding lines in the SDS-PAGE was analyzed using the ImageJ software. To estimate the IC50 value of Tigecycline (Tig, 0.1-5 μM) on the 55S mitoribosome in the mitochondrial lysate (Mito) and 80S human ribosome in the cytosolic lysate (Cyto), the intensities of positive controls derived from chloramphenicol (Cam) and CHX-treated samples, respectively, were subtracted. Second, the resulting intensities were normalized to the intensities of the negative controls, which in both cases were from the samples not treated with Tigecycline. Note that Tigecycline cannot sufficiently inhibit cytoplasmic translation even at high concentrations.

  • 1/16

    Tigecycline hydrochloride purchased from MedChemExpress. Usage Cited in: Microorganisms. 2024 Mar 13;12(3):575. [Abstract]

    Customer Validation
     Percentages of E. coli strains showing antimicrobial resistance to different antimicrobial agents. AMP, Ampicillin; CAZ, Ceftazidime; IPM, Imipenem; MRP, Meropenem; GEN, Gentamicin; OFX, Ofloxacin; SXT, Trimethoprim–sulfamethoxazole; TET, Tetracycline; TGC, Tigecycline; CL, Colistin; FFC, Florfenicol.

  • 1/16

    Tigecycline hydrochloride purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2022 Apr;78:103943. [Abstract]

    Customer Validation
     Tigecycline (4 μg/mL). Time-killing curves of tet(X3)-positive strains (E. coli DH5α+pAM401-tet(X3)), E. coli 47EC, and A. baumannii 34AB) with the indicated treatment. The bacterial CFUs per mL at different time points over 24 h were determined by plating.

  • 1/16

    Tigecycline hydrochloride purchased from MedChemExpress. Usage Cited in: Microbiol Spectr. 2023 Feb 14;11(1):e0323822. [Abstract]

    Customer Validation
     The MIC distributions of Tigecycline against 43 M. fortuitum isolates (incubate for 24 h). The y axis shows the number of strains with each MIC value, with the specific numbers shown above the bars.

  • 1/16

    Tigecycline hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Antimicrob Agents. 2018 Aug;52(2):269-271. [Abstract]

    Customer Validation
     Minimum inhibitory concentration (MIC) range as well as MIC50 and MIC90 values of the antibiotics tested against 121 Acinetobacter baumannii isolates from Greek hospitals.

  • Tigecycline hydrochloride