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  3. Amikacin disulfate

Amikacin disulfate (Synonyms: BAY 41-6551 disulfate)

Cat. No.: HY-B0509B Purity: >98.0%
Handling Instructions

Amikacin disulfate (BAY 41-6551 dissulfate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin disulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin disulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin disulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria.

For research use only. We do not sell to patients.

Amikacin disulfate Chemical Structure

Amikacin disulfate Chemical Structure

CAS No. : 39831-55-5

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Based on 2 publication(s) in Google Scholar

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Description

Amikacin disulfate (BAY 41-6551 dissulfate) is an aminoglycoside antibiotic and a semisynthetic analog of kanamycin. Amikacin disulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin disulfate is very active against most Gram-negative bacteria including gentamicin- and tobramycin-resistant strains. Amikacin disulfate also inhibits the infections caused by susceptible Nocardia and nontuberculous mycobacteria[1][2].

In Vitro

Amikacin offers definite advantages for treating infections caused by organisms resistant to other aminoglycosides. Amikaci is affected by relatively few arninoglycoside-modifying enzymes. Amikacin is useful in the treatment of infections caused by Nocardia asteroides, Mycobacterium avium-intracellulare, and certain species of "rapid-growing" mycobacteria (that is, M. chelonae and M. fortuitumi)[1].
Amikacin (100-1500 μM) causes a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD50 value of 453 μM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Amikacin (320 mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats) treatment increases the chance of serious hearing loss in rats in vivo[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Fischer 344 rats (40-50-day-old)[3]
Dosage: 320 mg/kg
Administration: Subcutaneous injection; daily; for 10 days
Result: Induced hearing loss in rats.
Clinical Trial
Molecular Weight

781.76

Formula

C₂₂H₄₇N₅O₂₁S₂

CAS No.

39831-55-5

SMILES
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Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (127.92 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2792 mL 6.3958 mL 12.7916 mL
5 mM 0.2558 mL 1.2792 mL 2.5583 mL
10 mM 0.1279 mL 0.6396 mL 1.2792 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

Amikacin disulfateBAY 41-6551 disulfateBacterialAntibioticAntimicrobialaminoglycosidesGram-negativebacillaryinfectionskanamycinototoxicribosomalproteinsynthesisInhibitorinhibitorinhibit

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Amikacin disulfate
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