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  3. Bacterial Antibiotic
  4. Tobramycin monosulfate

Tobramycin monosulfate  (Synonyms: Nebramycin Factor 6 monosulfate; Deoxykanamycin B monosulfate)

Cat. No.: HY-B0441B
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Tobramycin (Nebramycin Factor 6) monosulfate is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms. Tobramycin monosulfate can be used to pneumonia research caused by Pseudomonas aeruginosa.

For research use only. We do not sell to patients.

CAS No. : 126777-32-0

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Tobramycin monosulfate Related Antibodies

Top Publications Citing Use of Products

    Tobramycin monosulfate purchased from MedChemExpress. Usage Cited in: MedComm (2020). 2025 Jan 8;6(1):e70046.  [Abstract]

    Time-killing curves of drug combinations between STK848198 (0.5 µg/mL) and antibiotics with FICI≤ 0.5 [SM (8 µg/mL)/ Tobramycin (32 µg/mL)/ AMP (2 µg/mL)/ fosfomycin (0.5 µg/mL)/ SIS (32 µg/mL)/ gentamycin (8 µg/mL)].

    Tobramycin monosulfate purchased from MedChemExpress. Usage Cited in: AMB Express. 2024 Dec 24;14(1):141.  [Abstract]

    Combinational antimicrobial effects between PVB and conventional antibiotics against MRSA ATCC 43,300. Compound combinational activity between PVB and aminoglycosides, respectively. AMK, amikacin. GEN, gentamycin, KANA, kanamycin. TOB, Tobramycin (MICalone = 64 μg/mL; MICcombined = 256 μg/mL). SPC, spectinomycin.

    Tobramycin monosulfate purchased from MedChemExpress. Usage Cited in: ACS Infect Dis. 2024 Apr 12;10(4):1327-1338.  [Abstract]

    Synergistic antimicrobial efficacy between LP and Tobramycin (TOB) in a murine peritonitis model. The peritonitis mice (n = 6 mice/group) were applied with 5% Kolliphor + 5% ethanol (vehicle), 30 mg/kg VAN, 30 mg/kg LP, and 30 mg/kg TOB alone or in combination twice daily for 1 day. Representative viable cell colony count was collected from the kidney and spleen.

    Tobramycin monosulfate purchased from MedChemExpress. Usage Cited in: ACS Infect Dis. 2024 Apr 12;10(4):1327-1338.  [Abstract]

    Synergistic antimicrobial efficacy between LP and Tobramycin (TOB) in a murine peritonitis model. The peritonitis mice (n = 6 mice/group) were applied with 5% Kolliphor + 5% ethanol (vehicle), 30 mg/kg VAN, 30 mg/kg LP, and 30 mg/kg TOB alone or in combination twice daily for 1 day. The viable bacterial counts in the spleen were quantified.

    Tobramycin monosulfate purchased from MedChemExpress. Usage Cited in: ACS Infect Dis. 2024 Apr 12;10(4):1327-1338.  [Abstract]

    Synergistic antimicrobial efficacy between LP and Tobramycin (TOB) in a murine peritonitis model. The peritonitis mice (n = 6 mice/group) were applied with 5% Kolliphor + 5% ethanol (vehicle), 30 mg/kg VAN, 30 mg/kg LP, and 30 mg/kg TOB alone or in combination twice daily for 1 day. The viable bacterial counts in kidneys were quantified.

    Tobramycin monosulfate purchased from MedChemExpress. Usage Cited in: ACS Infect Dis. 2024 Apr 12;10(4):1327-1338.  [Abstract]

    Synergistic antimicrobial efficacy between LP and Tobramycin (TOB) in a murine peritonitis model. The peritonitis mice (n = 6 mice/group) were applied with 5% Kolliphor + 5% ethanol (vehicle), 30 mg/kg VAN, 30 mg/kg LP, and 30 mg/kg TOB alone or in combination twice daily for 1 day. Quantification of the inflammatory cytokine IL-6 in the serum.

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    Description

    Tobramycin (Nebramycin Factor 6) monosulfate is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms. Tobramycin monosulfate can be used to pneumonia research caused by Pseudomonas aeruginosa[1][2][3][4].

    IC50 & Target[1]

    Aminoglycoside

     

    In Vitro

    Tobramycin (0-50 ng/mL; 24 hours) monosulfate combinates with mycobacterium fortuitum enzyme (PodA) can greatly decreases P. aeruginosa cell viability[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Tobramycin monosulfate Related Antibodies
    In Vivo

    Tobramycin (50-400 mg/kg/day, i.p., once every 4h) monosulfate combinates with Meropenem (HY-13678) produces bacterial cell kill effect at low doses of both drugs in murine pneumonia model. [3].
    Tobramycin (s.c., single dose) monosulfate LD50 values in mice and rats are 441 and 969 mg/kg, respectively[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Murine Model of Pseudomonas aeruginosa Pneumonia Female, Swiss-Webster mice [3]
    Dosage: 50, 100, 150, 214, and 400 mg/kg/day
    Administration: Intraperitoneal injection (i.p.) ,once every 4h
    Result: Had near-maximal killing of the wild-type bacteria occurred at approximately 150 mg/kg/day when tobramycin alone.
    Combinated with Meropenem (HY-13678) produced near-maximal effect (i.e., bacterial cell kill) at low doses of both drugs (60 and 50 mg/kg/day for Meropenem (HY-13678) and tobramycin, respectively).
    Animal Model: Mice, rats, cats and dogs for toxicologic evaluation[4]
    Dosage: 7.5, 15, 30, 120, 441, 969 mg/kg
    Administration: Subcutaneous injection (s.c.), Intravenous injection (i.v.) ,Intramuscular injection(i.m.)
    Result: The s.c. LD50 values in mice and rats were 441 and 969 mg/kg, respectively.
    Within 1 hour after treated, death with central nervous system depression as a precursor occurred in rats and mice.
    A 100 mg/kg iv dose in chloraloseanesthetized catsproduced a moderate, transient decreasein blood pressure and a significant decrease in inspiratory volume and soleus twitch force.
    Changed renal tissue in rats which were given daily sc doses of 15-120 mg/kg for 3 months.
    im dose of 7.5 mg/kg for a l-month had no apparent effect on dogs, but a 30 mg/kg dose for a l-month produced severerenal damage.
    Molecular Weight

    565.59

    Formula

    C18H39N5O13S
    CAS No.
    SMILES

    O=S(O)(O)=O.O[C@@H]([C@@H]([C@H](C[C@H]1N)N)O[C@H]2O[C@@H]([C@H](C[C@H]2N)O)CN)[C@H]1O[C@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)N)O)CO
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Tobramycin monosulfate Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Tobramycin monosulfate126777-32-0Nebramycin Factor 6 monosulfate Deoxykanamycin B monosulfateBacterialAntibioticInhibitorinhibitorinhibit

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