Art. -Nr.: HY-B0441B

Tobramycin monosulfate

(Synonyms: Nebramycin Factor 6 monosulfate; Deoxykanamycin B monosulfate)

18 Cited Publications

Kundenbewertung

Based on 18 publication(s) in Google Scholar

Tobramycin (Nebramycin Factor 6) monosulfate is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms. Tobramycin monosulfate can be used to pneumonia research caused by Pseudomonas aeruginosa.

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CAS. Nr.: 126777-32-0
Formel: C₁₈H₃₉N₅O₁₃S
Molecular Weight:565.59

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Tobramycin monosulfate Chemical Structure

CAS. Nr.: 126777-32-0

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (18)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

Aminoglycoside

Alle Antibiotic Isoform-spezifische Produkte anzeigen :

In Vitro

Tobramycin (0-50 ng/mL; 24 hours) monosulfate combinates with mycobacterium fortuitum enzyme (PodA) can greatly decreases P. aeruginosa cell viability^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tobramycin (50-400 mg/kg/day, i.p., once every 4h) monosulfate combinates with Meropenem (HY-13678) produces bacterial cell kill effect at low doses of both drugs in murine pneumonia model. ^[3].
Tobramycin (s.c., single dose) monosulfate LD₅₀ values in mice and rats are 441 and 969 mg/kg, respectively^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Murine Model of Pseudomonas aeruginosa Pneumonia Female, Swiss-Webster mice ^[3]
Dosage:

50, 100, 150, 214, and 400 mg/kg/day
Administration:

Intraperitoneal injection (i.p.) ,once every 4h
Result:

Had near-maximal killing of the wild-type bacteria occurred at approximately 150 mg/kg/day when tobramycin alone.
Combinated with Meropenem (HY-13678) produced near-maximal effect (i.e., bacterial cell kill) at low doses of both drugs (60 and 50 mg/kg/day for Meropenem (HY-13678) and tobramycin, respectively).

Animal Model:

Mice, rats, cats and dogs for toxicologic evaluation^[4]
Dosage:

7.5, 15, 30, 120, 441, 969 mg/kg
Administration:

Subcutaneous injection (s.c.), Intravenous injection (i.v.) ,Intramuscular injection(i.m.)
Result:

The s.c. LD₅₀ values in mice and rats were 441 and 969 mg/kg, respectively.
Within 1 hour after treated, death with central nervous system depression as a precursor occurred in rats and mice.
A 100 mg/kg iv dose in chloraloseanesthetized catsproduced a moderate, transient decreasein blood pressure and a significant decrease in inspiratory volume and soleus twitch force.
Changed renal tissue in rats which were given daily sc doses of 15-120 mg/kg for 3 months.
im dose of 7.5 mg/kg for a l-month had no apparent effect on dogs, but a 30 mg/kg dose for a l-month produced severerenal damage.

Chemical Information

CAS. Nr. 126777-32-0
Molecular Weight 565.59
Formel C₁₈H₃₉N₅O₁₃S
SMILES

O=S(O)(O)=O.O[C@@H]([C@@H]([C@H](C[C@H]1N)N)O[C@H]2O[C@@H]([C@H](C[C@H]2N)O)CN)[C@H]1O[C@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)N)O)CO
Synonyms

Nebramycin Factor 6 monosulfate; Deoxykanamycin B monosulfate
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (18)

All Microbiological AssayIn Vivo Efficacy Study

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Journal Impact Factor

Signal Transduct Target Ther

Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]

2025 Dec 15;10(1):406. PMID: 41392286
Nat Commun

Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China. [Abstract]

2022 Mar 2;13(1):1116. PMID: 35236849
MedComm (2020)

Novel antibiotics against Staphylococcus aureus without detectable resistance by targeting proton motive force and FtsH. [Abstract]

2025 Jan 8;6(1):e70046. PMID: 39781293

Tobramycin monosulfate purchased from MedChemExpress. Usage Cited in: MedComm (2020). 2025 Jan 8;6(1):e70046. [Abstract]

Time-killing curves of drug combinations between STK848198 (0.5 µg/mL) and antibiotics with FICI≤ 0.5 [SM (8 µg/mL)/ Tobramycin (32 µg/mL)/ AMP (2 µg/mL)/ fosfomycin (0.5 µg/mL)/ SIS (32 µg/mL)/ gentamycin (8 µg/mL)].
J Exp Med

Antibiotic use in early life impairs MAIT cell-mediated immunity in adulthood. [Abstract]

2026 Mar 2;223(3):e20241287. PMID: 41400657
NPJ Biofilms Microbiomes

Echinacoside reduces intracellular c-di-GMP levels and potentiates tobramycin activity against Pseudomonas aeruginosa biofilm aggregates. [Abstract]

2025 Mar 7;11(1):40. PMID: 40055321
Food Chem

Electrochemical sensor for detecting streptomycin in milk based on label-free aptamer chain and magnetic adsorption. [Abstract]

2023 Mar 1:403:134399. PMID: 36182859
Virulence

Antibacterial efficacy and mechanism of the novel antimicrobial peptide lachnospirin-1 against Acinetobacter baumannii. [Abstract]

2026 Dec 31;17(1):2646808. PMID: 41838520
Int J Mol Sci

Discovery of TRPV4-Targeting Small Molecules with Anti-Influenza Effects Through Machine Learning and Experimental Validation. [Abstract]

2025 Feb 6;26(3):1381. PMID: 39941149
Appl Microbiol Biotechnol

Anti-hepatitis C virus drug simeprevir: a promising antimicrobial agent against MRSA. [Abstract]

2022 Apr;106(7):2689-2702. PMID: 35338386
ACS Infect Dis

Lusutrombopag as a Repurposing Drug in Combination with Aminoglycosides against Vancomycin-Resistant Enterococcus. [Abstract]

2024 Apr 12;10(4):1327-1338. PMID: 38567846

Tobramycin monosulfate purchased from MedChemExpress. Usage Cited in: ACS Infect Dis. 2024 Apr 12;10(4):1327-1338. [Abstract]

Synergistic antimicrobial efficacy between LP and Tobramycin (TOB) in a murine peritonitis model. The peritonitis mice (n = 6 mice/group) were applied with 5% Kolliphor + 5% ethanol (vehicle), 30 mg/kg VAN, 30 mg/kg LP, and 30 mg/kg TOB alone or in combination twice daily for 1 day. Representative viable cell colony count was collected from the kidney and spleen.

Tobramycin monosulfate purchased from MedChemExpress. Usage Cited in: ACS Infect Dis. 2024 Apr 12;10(4):1327-1338. [Abstract]

Synergistic antimicrobial efficacy between LP and Tobramycin (TOB) in a murine peritonitis model. The peritonitis mice (n = 6 mice/group) were applied with 5% Kolliphor + 5% ethanol (vehicle), 30 mg/kg VAN, 30 mg/kg LP, and 30 mg/kg TOB alone or in combination twice daily for 1 day. The viable bacterial counts in the spleen were quantified.

Tobramycin monosulfate purchased from MedChemExpress. Usage Cited in: ACS Infect Dis. 2024 Apr 12;10(4):1327-1338. [Abstract]

Synergistic antimicrobial efficacy between LP and Tobramycin (TOB) in a murine peritonitis model. The peritonitis mice (n = 6 mice/group) were applied with 5% Kolliphor + 5% ethanol (vehicle), 30 mg/kg VAN, 30 mg/kg LP, and 30 mg/kg TOB alone or in combination twice daily for 1 day. The viable bacterial counts in kidneys were quantified.

Tobramycin monosulfate purchased from MedChemExpress. Usage Cited in: ACS Infect Dis. 2024 Apr 12;10(4):1327-1338. [Abstract]

Synergistic antimicrobial efficacy between LP and Tobramycin (TOB) in a murine peritonitis model. The peritonitis mice (n = 6 mice/group) were applied with 5% Kolliphor + 5% ethanol (vehicle), 30 mg/kg VAN, 30 mg/kg LP, and 30 mg/kg TOB alone or in combination twice daily for 1 day. Quantification of the inflammatory cytokine IL-6 in the serum.
AMB Express

Repurposing pinaverium bromide against Staphylococcus and its biofilms with new mechanisms. [Abstract]

2024 Dec 24;14(1):141. PMID: 39718732

Tobramycin monosulfate purchased from MedChemExpress. Usage Cited in: AMB Express. 2024 Dec 24;14(1):141. [Abstract]

Combinational antimicrobial effects between PVB and conventional antibiotics against MRSA ATCC 43,300. Compound combinational activity between PVB and aminoglycosides, respectively. AMK, amikacin. GEN, gentamycin, KANA, kanamycin. TOB, Tobramycin (MIC_alone = 64 μg/mL; MIC_combined = 256 μg/mL). SPC, spectinomycin.
Infect Drug Resist

2026 May 8;19.
Theriogenology

Dual roles of the TLR2/TLR4/NLRP3-H-PGDS-PGD2 axis in regulating the inflammatory response in Escherichia coli-infected bovine bone marrow-derived macrophages and endometrial tissue. [Abstract]

2025 Jun:239:117374. PMID: 40112766
Curr Microbiol

Repurposing Sitafloxacin, Prulifloxacin, Tosufloxacin, and Sisomicin as Antimicrobials Against Biofilm and Persister Cells of Pseudomonas aeruginosa. [Abstract]

2021 Dec 14;79(1):12. PMID: 34905092
J Microbiol Methods

Comparison of agar-based and checkerboard methods to assess phage-antimicrobial synergy in Pseudomonas aeruginosa. [Abstract]

2026 Feb 25:107441. PMID: 41759663
Basic Clin Androl

Pelvic vasectomy and its protective effects on rat testis function. [Abstract]

2025 Mar 7;35(1):9. PMID: 40055615
bioRxiv

2024 May 10.
bioRxiv

2024 Feb 9.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Tobramycin. [Content Brief]

[2]. VanDrisse CM, et.al. Computationally designed pyocyanin demethylase acts synergistically with tobramycin to kill recalcitrant Pseudomonas aeruginosa biofilms. Proc Natl Acad Sci U S A. 2021 Mar 23;118(12):e2022012118. [Content Brief]

[3]. Louie A, et.al. Impact of meropenem in combination with tobramycin in a murine model of Pseudomonas aeruginosa pneumonia. Antimicrob Agents Chemother. 2013 Jun;57(6):2788-92. [Content Brief]

[4]. Welles JS, et.al. Preclinical toxicology studies with tobramycin. Toxicol Appl Pharmacol. 1973 Jul;25(3):398-409. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Tobramycin monosulfate

18 Cited Publications

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Tobramycin monosulfate

Publications Citing Use of MedChemExpress (MCE) Tobramycin monosulfate

Alle Antibiotic Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (18)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Tobramycin monosulfate Related Classifications

HY-B0441B Related Classifications