Tobramycin monosulfate
Based on 17 publication(s) in Google Scholar
Tobramycin (Nebramycin Factor 6) monosulfate is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms. Tobramycin monosulfate can be used to pneumonia research caused by Pseudomonas aeruginosa.
For research use only. We do not sell to patients.
- CAS No.: 126777-32-0
- Formula: C18H39N5O13S
- Molecular Weight:565.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Publications Citing Use of MedChemExpress (MCE) Tobramycin monosulfate
More- Signal Transduct Target Ther. 2025 Dec 15;10(1):406. [Abstract]
- Nat Commun. 2022 Mar 2;13(1):1116. [Abstract]
- MedComm (2020). 2025 Jan 8;6(1):e70046. [Abstract]
- J Exp Med. 2026 Mar 2;223(3):e20241287. [Abstract]
- Food Chem. 2023 Mar 1:403:134399. [Abstract]
- Virulence. 2026 Dec 31;17(1):2646808. [Abstract]
- Int J Mol Sci. 2025 Feb 6;26(3):1381. [Abstract]
- Appl Microbiol Biotechnol. 2022 Apr;106(7):2689-2702. [Abstract]
- ACS Infect Dis. 2024 Apr 12;10(4):1327-1338. [Abstract]
- AMB Express. 2024 Dec 24;14(1):141. [Abstract]
- Infect Drug Resist. 2026 May 8;19.
- Curr Microbiol. 2021 Dec 14;79(1):12. [Abstract]
- Theriogenology. 2025 Jun:239:117374. [Abstract]
- Basic Clin Androl. 2025 Mar 7;35(1):9. [Abstract]
- J Microbiol Methods. 2026 Feb 25:107441. [Abstract]
- bioRxiv. 2024 May 10.
- bioRxiv. 2024 Feb 9.
Customer Validation & Images
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Microbiological Assay
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Microbiological Assay
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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In Vivo Efficacy Study
All Antibiotic Isoforms
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Biological Activity
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Aminoglycoside |
Tobramycin (0-50 ng/mL; 24 hours) monosulfate combinates with mycobacterium fortuitum enzyme (PodA) can greatly decreases P. aeruginosa cell viability[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Tobramycin (s.c., single dose) monosulfate LD50 values in mice and rats are 441 and 969 mg/kg, respectively[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Murine Model of Pseudomonas aeruginosa Pneumonia Female, Swiss-Webster mice [3]
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Dosage:50, 100, 150, 214, and 400 mg/kg/day
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Administration:Intraperitoneal injection (i.p.) ,once every 4h
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Result:Had near-maximal killing of the wild-type bacteria occurred at approximately 150 mg/kg/day when tobramycin alone.
Combinated with Meropenem (HY-13678) produced near-maximal effect (i.e., bacterial cell kill) at low doses of both drugs (60 and 50 mg/kg/day for Meropenem (HY-13678) and tobramycin, respectively).
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Animal Model:Mice, rats, cats and dogs for toxicologic evaluation[4]
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Dosage:7.5, 15, 30, 120, 441, 969 mg/kg
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Administration:Subcutaneous injection (s.c.), Intravenous injection (i.v.) ,Intramuscular injection(i.m.)
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Result:The s.c. LD50 values in mice and rats were 441 and 969 mg/kg, respectively.
Within 1 hour after treated, death with central nervous system depression as a precursor occurred in rats and mice.
A 100 mg/kg iv dose in chloraloseanesthetized catsproduced a moderate, transient decreasein blood pressure and a significant decrease in inspiratory volume and soleus twitch force.
Changed renal tissue in rats which were given daily sc doses of 15-120 mg/kg for 3 months.
im dose of 7.5 mg/kg for a l-month had no apparent effect on dogs, but a 30 mg/kg dose for a l-month produced severerenal damage.
Chemical Information
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CAS No. 126777-32-0
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Molecular Weight 565.59
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Formula C18H39N5O13S
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SMILES
O=S(O)(O)=O.O[C@@H]([C@@H]([C@H](C[C@H]1N)N)O[C@H]2O[C@@H]([C@H](C[C@H]2N)O)CN)[C@H]1O[C@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)N)O)CO
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Synonyms
Nebramycin Factor 6 monosulfate; Deoxykanamycin B monosulfate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (17)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Nat Commun
Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China. [Abstract]2022 Mar 2;13(1):1116. PMID: 35236849 -
MedComm (2020)
Novel antibiotics against Staphylococcus aureus without detectable resistance by targeting proton motive force and FtsH. [Abstract]2025 Jan 8;6(1):e70046. PMID: 39781293
Tobramycin monosulfate purchased from MedChemExpress. Usage Cited in: MedComm (2020). 2025 Jan 8;6(1):e70046. [Abstract]
Time-killing curves of drug combinations between STK848198 (0.5 µg/mL) and antibiotics with FICI≤ 0.5 [SM (8 µg/mL)/ Tobramycin (32 µg/mL)/ AMP (2 µg/mL)/ fosfomycin (0.5 µg/mL)/ SIS (32 µg/mL)/ gentamycin (8 µg/mL)].
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J Exp Med
2026 Mar 2;223(3):e20241287. PMID: 41400657 -
Food Chem
Electrochemical sensor for detecting streptomycin in milk based on label-free aptamer chain and magnetic adsorption. [Abstract]2023 Mar 1:403:134399. PMID: 36182859 -
Virulence
Antibacterial efficacy and mechanism of the novel antimicrobial peptide lachnospirin-1 against Acinetobacter baumannii. [Abstract]2026 Dec 31;17(1):2646808. PMID: 41838520 -
Int J Mol Sci
Discovery of TRPV4-Targeting Small Molecules with Anti-Influenza Effects Through Machine Learning and Experimental Validation. [Abstract]2025 Feb 6;26(3):1381. PMID: 39941149 -
Appl Microbiol Biotechnol
2022 Apr;106(7):2689-2702. PMID: 35338386 -
ACS Infect Dis
Lusutrombopag as a Repurposing Drug in Combination with Aminoglycosides against Vancomycin-Resistant Enterococcus. [Abstract]2024 Apr 12;10(4):1327-1338. PMID: 38567846
Tobramycin monosulfate purchased from MedChemExpress. Usage Cited in: ACS Infect Dis. 2024 Apr 12;10(4):1327-1338. [Abstract]
Synergistic antimicrobial efficacy between LP and Tobramycin (TOB) in a murine peritonitis model. The peritonitis mice (n = 6 mice/group) were applied with 5% Kolliphor + 5% ethanol (vehicle), 30 mg/kg VAN, 30 mg/kg LP, and 30 mg/kg TOB alone or in combination twice daily for 1 day. Representative viable cell colony count was collected from the kidney and spleen.
Tobramycin monosulfate purchased from MedChemExpress. Usage Cited in: ACS Infect Dis. 2024 Apr 12;10(4):1327-1338. [Abstract]
Synergistic antimicrobial efficacy between LP and Tobramycin (TOB) in a murine peritonitis model. The peritonitis mice (n = 6 mice/group) were applied with 5% Kolliphor + 5% ethanol (vehicle), 30 mg/kg VAN, 30 mg/kg LP, and 30 mg/kg TOB alone or in combination twice daily for 1 day. The viable bacterial counts in the spleen were quantified.
Tobramycin monosulfate purchased from MedChemExpress. Usage Cited in: ACS Infect Dis. 2024 Apr 12;10(4):1327-1338. [Abstract]
Synergistic antimicrobial efficacy between LP and Tobramycin (TOB) in a murine peritonitis model. The peritonitis mice (n = 6 mice/group) were applied with 5% Kolliphor + 5% ethanol (vehicle), 30 mg/kg VAN, 30 mg/kg LP, and 30 mg/kg TOB alone or in combination twice daily for 1 day. The viable bacterial counts in kidneys were quantified.
Tobramycin monosulfate purchased from MedChemExpress. Usage Cited in: ACS Infect Dis. 2024 Apr 12;10(4):1327-1338. [Abstract]
Synergistic antimicrobial efficacy between LP and Tobramycin (TOB) in a murine peritonitis model. The peritonitis mice (n = 6 mice/group) were applied with 5% Kolliphor + 5% ethanol (vehicle), 30 mg/kg VAN, 30 mg/kg LP, and 30 mg/kg TOB alone or in combination twice daily for 1 day. Quantification of the inflammatory cytokine IL-6 in the serum.
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AMB Express
Repurposing pinaverium bromide against Staphylococcus and its biofilms with new mechanisms. [Abstract]2024 Dec 24;14(1):141. PMID: 39718732
Tobramycin monosulfate purchased from MedChemExpress. Usage Cited in: AMB Express. 2024 Dec 24;14(1):141. [Abstract]
Combinational antimicrobial effects between PVB and conventional antibiotics against MRSA ATCC 43,300. Compound combinational activity between PVB and aminoglycosides, respectively. AMK, amikacin. GEN, gentamycin, KANA, kanamycin. TOB, Tobramycin (MICalone = 64 μg/mL; MICcombined = 256 μg/mL). SPC, spectinomycin.
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Curr Microbiol
Repurposing Sitafloxacin, Prulifloxacin, Tosufloxacin, and Sisomicin as Antimicrobials Against Biofilm and Persister Cells of Pseudomonas aeruginosa. [Abstract]2021 Dec 14;79(1):12. PMID: 34905092 -
Theriogenology
Dual roles of the TLR2/TLR4/NLRP3-H-PGDS-PGD2 axis in regulating the inflammatory response in Escherichia coli-infected bovine bone marrow-derived macrophages and endometrial tissue. [Abstract]2025 Jun:239:117374. PMID: 40112766 -
Basic Clin Androl
2025 Mar 7;35(1):9. PMID: 40055615 -
J Microbiol Methods
Comparison of agar-based and checkerboard methods to assess phage-antimicrobial synergy in Pseudomonas aeruginosa. [Abstract]2026 Feb 25:107441. PMID: 41759663 -
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Purity & Documentation
References
[1]. Tobramycin. [Content Brief]
[2]. VanDrisse CM, et.al. Computationally designed pyocyanin demethylase acts synergistically with tobramycin to kill recalcitrant Pseudomonas aeruginosa biofilms. Proc Natl Acad Sci U S A. 2021 Mar 23;118(12):e2022012118. [Content Brief]
[3]. Louie A, et.al. Impact of meropenem in combination with tobramycin in a murine model of Pseudomonas aeruginosa pneumonia. Antimicrob Agents Chemother. 2013 Jun;57(6):2788-92. [Content Brief]
[4]. Welles JS, et.al. Preclinical toxicology studies with tobramycin. Toxicol Appl Pharmacol. 1973 Jul;25(3):398-409. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tobramycin monosulfate Related Classifications
HY-B0441B Related Classifications
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