2. Anti-infection
  3. Bacterial
  4. Ceftolozane sulfate

Ceftolozane sulfate  (Synonyms: CXA-101; FR264205)

Cat. No.: HY-19806A
COA Handling Instructions

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Ceftolozane (CXA-101) sulfate is an antipseudomonal cephalosporin. Ceftolozane sulfate inhibits P. aeruginosa PAO1 with an MIC of 0.5 μg/mL. Ceftolozane sulfate can also inhibit β-lactam-resistant P. aeruginosa.

For research use only. We do not sell to patients.

Ceftolozane sulfate Chemical Structure

Ceftolozane sulfate Chemical Structure

CAS No. : 936111-69-2

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Other Forms of Ceftolozane sulfate:

Ceftolozane sulfate Related Antibodies

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Description

Ceftolozane (CXA-101) sulfate is an antipseudomonal cephalosporin. Ceftolozane sulfate inhibits P. aeruginosa PAO1 with an MIC of 0.5 μg/mL. Ceftolozane sulfate can also inhibit β-lactam-resistant P. aeruginosa[1][2].

IC50 & Target

MIC: 0.5 μg/mL (P. aeruginosa PAO1)[1]
Molecular Weight

764.77

Formula

C23H32N12O12S3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(O)(O)=O.CN1[N+](CC(CS[C@]2([H])[C@@H]3NC(/C(C4=NSC(N)=N4)=N\OC(C)(C(O)=O)C)=O)=C(C([O-])=O)N2C3=O)=CC(NC(NCCN)=O)=C1N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (65.38 mM; ultrasonic and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3076 mL 6.5379 mL 13.0758 mL
5 mM 0.2615 mL 1.3076 mL 2.6152 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.97%

COA (253 KB) HNMR (264 KB) LCMS (100 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3076 mL 6.5379 mL 13.0758 mL 32.6896 mL
5 mM 0.2615 mL 1.3076 mL 2.6152 mL 6.5379 mL
10 mM 0.1308 mL 0.6538 mL 1.3076 mL 3.2690 mL
15 mM 0.0872 mL 0.4359 mL 0.8717 mL 2.1793 mL
20 mM 0.0654 mL 0.3269 mL 0.6538 mL 1.6345 mL
25 mM 0.0523 mL 0.2615 mL 0.5230 mL 1.3076 mL
30 mM 0.0436 mL 0.2179 mL 0.4359 mL 1.0897 mL
40 mM 0.0327 mL 0.1634 mL 0.3269 mL 0.8172 mL
50 mM 0.0262 mL 0.1308 mL 0.2615 mL 0.6538 mL
60 mM 0.0218 mL 0.1090 mL 0.2179 mL 0.5448 mL
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Ceftolozane sulfate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ceftolozane936111-69-2CXA-101 FR264205CXA101CXA 101FR264205FR 264205FR-264205BacterialP. aeruginosaβ-lactamaseInhibitorinhibitorinhibit

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