2. Anti-infection
  3. Antibiotic Bacterial
  4. Polymyxin B2

Polymyxin B2 is a polypeptide antibiotic with particularly potent antibacterial activity against Gram-negative bacteria. Polymyxin B2 kills bacteria by binding to lipopolysaccharide molecules on the bacterial cell membrane, disrupting membrane integrity and causing leakage of intracellular contents. Polymyxin B2 is used in studies related to Pseudomonas aeruginosa infection and acute enteritis.

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Custom Peptide Synthesis

Polymyxin B2

Polymyxin B2 Chemical Structure

CAS No. : 34503-87-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in Water In-stock
Solid
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Polymyxin B2 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Polymyxin B2 is a polypeptide antibiotic with particularly potent antibacterial activity against Gram-negative bacteria. Polymyxin B2 kills bacteria by binding to lipopolysaccharide molecules on the bacterial cell membrane, disrupting membrane integrity and causing leakage of intracellular contents. Polymyxin B2 is used in studies related to Pseudomonas aeruginosa infection and acute enteritis[1][2].

Cellular Effect
Cell Line Type Value Description References
Vero CC50
159 μg/mL
Compound: Polymyxin B2
Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay
[PMID: 29412662]
In Vivo

Polymyxin B2 endogenously produced and stimulated by Lactiplantibacillus plantarum MS2c alone or combined with Saccharomyces cerevisiae Y301 fermented coconut water interventions, correlates with reduced pathogenic Alistipes abundance and contributes to recovery from DSS (HY-116282C)-induced acute enteritis in Wenchang chicks[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1189.45

Formula

C55H96N16O13
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (84.07 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8407 mL 4.2036 mL 8.4072 mL
5 mM 0.1681 mL 0.8407 mL 1.6814 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.8407 mL 4.2036 mL 8.4072 mL 21.0181 mL
5 mM 0.1681 mL 0.8407 mL 1.6814 mL 4.2036 mL
10 mM 0.0841 mL 0.4204 mL 0.8407 mL 2.1018 mL
15 mM 0.0560 mL 0.2802 mL 0.5605 mL 1.4012 mL
20 mM 0.0420 mL 0.2102 mL 0.4204 mL 1.0509 mL
25 mM 0.0336 mL 0.1681 mL 0.3363 mL 0.8407 mL
30 mM 0.0280 mL 0.1401 mL 0.2802 mL 0.7006 mL
40 mM 0.0210 mL 0.1051 mL 0.2102 mL 0.5255 mL
50 mM 0.0168 mL 0.0841 mL 0.1681 mL 0.4204 mL
60 mM 0.0140 mL 0.0701 mL 0.1401 mL 0.3503 mL
80 mM 0.0105 mL 0.0525 mL 0.1051 mL 0.2627 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Polymyxin B2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Polymyxin B234503-87-2Polymyxin B 2Polymyxin B-2AntibioticBacterialSaccharomyces cerevisiae Y301Wenchang chicksAlistipesPseudomonas aeruginosa PA103dextran sulfate sodiumPseudomonas aeruginosaacute enteritisLactiplantibacillus plantarum MS2cLL37pseudomonas aeruginosa infectionsInhibitorinhibitorinhibit

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