Polymyxin B2 Sulfate 

Polymyxin B2 Sulfate is a polypeptide antibiotic with particularly potent antibacterial activity against Gram-negative bacteria. Polymyxin B2 Sulfate kills bacteria by binding to lipopolysaccharide molecules on the bacterial cell membrane, disrupting membrane integrity and causing leakage of intracellular contents. Polymyxin B2 Sulfate is used in studies related to Pseudomonas aeruginosa infection and acute enteritis^[1][2].

Polymyxin B2 Sulfate endogenously produced and stimulated by Lactiplantibacillus plantarum MS2c alone or combined with Saccharomyces cerevisiae Y301 fermented coconut water interventions, correlates with reduced pathogenic Alistipes abundance and contributes to recovery from DSS (HY-116282C)-induced acute enteritis in Wenchang chicks^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1189.45 (free base)

C₅₅H₉₆N₁₆O₁₃.xH₂SO₄

108965-69-1

O=C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@@]1([H])[C@H](O)C)=O)CCN)=O)([H])CCN)=O)CC(C)C)[C@H](NC([C@@H](NC([C@@](CCNC1=O)([H])NC([C@H](CCN)NC([C@H]([C@H](O)C)NC([C@H](CCN)NC(CCCCC(C)C)=O)=O)=O)=O)=O)CCN)=O)CC2=CC=CC=C2.O=S(O)(O)=O.[x]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Han W, et al. New antimicrobial peptide-antibiotic combination strategy for Pseudomonas aeruginosa inactivation. Biointerphases. 2022;17(4):041002. Published 2022 Aug 3.

  [2]. Zheng L, et al. Lactiplantibacillus plantarum and Saccharomyces cerevisiae-Fermented Coconut Water Alleviates Dextran Sodium Sulfate-Induced Enteritis in Wenchang Chicken: A Gut Microbiota and Metabolomic Approach. Animals (Basel). 2024 Feb 8;14(4):575.