108965-69-1
Chemical Structure
Polymyxin B2 Sulfate
- CAS No.: 108965-69-1
- Formula:C55H96N16O13.xH2SO4
- Molecular Weight:1189.45 (free base)
SMILES: O=C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@@]1([H])[C@H](O)C)=O)CCN)=O)([H])CCN)=O)CC(C)C)[C@H](NC([C@@H](NC([C@@](CCNC1=O)([H])NC([C@H](CCN)NC([C@H]([C@H](O)C)NC([C@H](CCN)NC(CCCCC(C)C)=O)=O)=O)=O)=O)CCN)=O)CC2=CC=CC=C2.O=S(O)(O)=O.[x]
Biological Activity: Polymyxin B2 Sulfate is a polypeptide antibiotic with particularly potent antibacterial activity against Gram-negative bacteria. Polymyxin B2 Sulfate kills bacteria by binding to lipopolysaccharide molecules on the bacterial cell membrane, disrupting membrane integrity and causing leakage of intracellular contents. Polymyxin B2 Sulfate is used in studies related to Pseudomonas aeruginosa infection and acute enteritis[1][2].
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Polymyxin B2 Sulfate | Polymyxin B2 Sulfate is a polypeptide antibiotic with particularly potent antibacterial activity against Gram-negative bacteria. Polymyxin B2 Sulfate kills bacteria by binding to lipopolysaccharide molecules on the bacterial cell membrane, disrupting membrane integrity and causing leakage of intracellular contents. Polymyxin B2 Sulfate is used in studies related to Pseudomonas aeruginosa infection and acute enteritis. | |||||||||||||||||||||
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- [1]. Han W, et al. New antimicrobial peptide-antibiotic combination strategy for Pseudomonas aeruginosa inactivation. Biointerphases. 2022;17(4):041002. Published 2022 Aug 3. [Content Brief]
- [2]. Zheng L, et al. Lactiplantibacillus plantarum and Saccharomyces cerevisiae-Fermented Coconut Water Alleviates Dextran Sodium Sulfate-Induced Enteritis in Wenchang Chicken: A Gut Microbiota and Metabolomic Approach. Animals (Basel). 2024 Feb 8;14(4):575. [Content Brief]
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