2. Anti-infection Metabolic Enzyme/Protease
  3. Bacterial Elastase
  4. PV-DPD-19

PV-DPD-19 is an autoinducer-2 (AI-2) quorum sensing inhibitor. PV-DPD-19 reduces AI-2 production and inhibits the expression of multiple MSCRAMMs. In co-culture systems with Staphylococcus aureus, PV-DPD-19 decreases the production of pyocyanin and Elastase in Pseudomonas aeruginosa. PV-DPD-19 impairs the adhesion ability of Staphylococcus aureus to lung epithelial cells. PV-DPD-19 inhibits biofilm formation of Pseudomonas aeruginosa (MBIC50 = 27 μg/mL) and Staphylococcus aureus (MBIC50 = 35 μg/mL). PV-DPD-19 shows no cytotoxicity in both in vitro lung epithelial cell models and in vivo Galleria mellonella larva models.

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PV-DPD-19

PV-DPD-19 Chemical Structure

CAS No. : 3112321-20-4

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PV-DPD-19 Related Antibodies

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Description

PV-DPD-19 is an autoinducer-2 (AI-2) quorum sensing inhibitor. PV-DPD-19 reduces AI-2 production and inhibits the expression of multiple MSCRAMMs. In co-culture systems with Staphylococcus aureus, PV-DPD-19 decreases the production of pyocyanin and Elastase in Pseudomonas aeruginosa. PV-DPD-19 impairs the adhesion ability of Staphylococcus aureus to lung epithelial cells. PV-DPD-19 inhibits biofilm formation of Pseudomonas aeruginosa (MBIC50 = 27 μg/mL) and Staphylococcus aureus (MBIC50 = 35 μg/mL). PV-DPD-19 shows no cytotoxicity in both in vitro lung epithelial cell models and in vivo Galleria mellonella larva models[1].

In Vitro

PV-DPD-19 inhibits biofilm formation by *Pseudomonas aeruginosa* (MBIC50 = 27 μg/mL) and *Staphylococcus aureus* (MBIC50 = 35 μg/mL)[1].
PV-DPD-19 significantly reduces the adhesion rate of *Staphylococcus aureus* to human A549 epithelial cells by approximately 30%[1].
PV-DPD-19 (2 mM; overnight, 8 h) significantly reduces AI-2 production in *Staphylococcus aureus* SH1000 as determined by the *Vibrio harveyi* bioluminescence assay[1].
PV-DPD-19 (20-40 μM; 16 h) reduces pyocyanin production in *Pseudomonas aeruginosa* PAO1 in a dose-dependent manner[1].
PV-DPD-19 (3.12-200 μM; 24 h) shows no cytotoxicity against epithelial cell line A549[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PV-DPD-19 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: human alveolar basal epithelial carcinoma A549 cells
Concentration: 3.12-200 μM
Incubation Time: 24 h
Result: Maintained cell viability at 100% for all compounds.
Showed no statistically significant reduction in viability.
In Vivo

PV-DPD-19 (1-200 μM; injected into the proleg using a microsyringe; single dose) shows no visible acute toxicity to Galleria mellonella (greater wax moth) larvae even at concentrations up to 200 μM, with the survival rate maintained at ≥97% within 72 h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: larvae (0.2-0.3 g in weight)[1]
Dosage: 1 μM; 100 μM; 200 μM
Administration: injected into the proleg using a microsyringe; single dose
Result: Observed 100% survival at 24 hours post-injection for all doses.
Observed 100% survival at 48 hours post-injection for 1 μM and 200 μM doses, and 97% survival for 100 μM dose.
Observed 98% survival at 72 hours post-injection for 1 μM and 200 μM doses, and 97% survival for 100 μM dose.
Showed no significant survival difference compared to untreated controls.
Molecular Weight

293.32

Formula

C15H19NO5
CAS No.
SMILES

CC1(C)OC(C(N[C@@H](CC2=CC=CC=C2)C(O)=O)=O)CO1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PV-DPD-19 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PV-DPD-193112321-20-4BacterialElastaseα-hemolysinquorum sensing inhibitorpyocyaninelastaseStaphylococcus aureusPseudomonas aeruginosaGalleria mellonellaprotein SpAautoinducer-2human lung epithelial cellsInhibitorinhibitorinhibit

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