Polybia-MP1
Based on 1 Customer Validation
Polybia-MP1 is an antimicrobial peptide with antibacterial, antifungal and anticancer activities. Polybia-MP1 selectively targets cancer cells by interacting with PS and PE in the outer leaflet of cell membranes, and induces necrosis via pore formation. Polybia-MP1 exhibits antibacterial activity against Pseudomonas aeruginosa. Polybia-MP1 can be used in research related to bacterial infections, fungal infections and cancers.
For research use only. We do not sell to patients.
- Purity: 99.03%
- CAS No.: 872043-01-1
- Formula: C78H132N20O19
- Molecular Weight:1654.01
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Polybia-MP1 (15-30 μg/mL; 3 h) exhibits stronger antibacterial activity against Pseudomonas aeruginosa cells pre-incubated with DP, and the proportions of viable cells are significantly lower at doses of 9 μM and 18 μM[2].
Polybia-MP1 selectively targets cancer cells by interacting with PS and PE in the outer leaflet of the cell membrane, induces necrosis via pore formation, and reaches 90% of its maximum anticancer activity within 30 min to 1 h[3].
Polybia-MP1 exhibits potent antibacterial, antifungal and biofilm inhibitory activities, while showing low activity against cholesterol-rich normal mammalian cell membranes[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 872043-01-1
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Appearance Solid
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Molecular Weight 1654.01
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Formula C78H132N20O19
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Color White to off-white
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Sequence
Ile-Asp-Trp-Lys-Lys-Leu-Leu-Asp-Ala-Ala-Lys-Gln-Ile-Leu-NH2
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Sequence Shortening
IDWKKLLDAAKQIL-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (259 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. dos Santos Cabrera MP, et al. Selectivity in the mechanism of action of antimicrobial mastoparan peptide Polybia-MP1. Eur Biophys J. 2008;37(6):879-891. [Content Brief]
[2]. Alvares DS, et al. The antimicrobial peptide Polybia-MP1 differentiates membranes with the hopanoid, diplopterol from those with cholesterol. BBA Adv. 2021;1:100002. Published 2021 Jan 30. [Content Brief]
[3]. Xuan HL, et al. Chemical approaches in the development of natural nontoxic peptide Polybia-MP1 as a potential dual antimicrobial and antitumor agent. Amino Acids. 2021;53(6):843-852. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Polybia-MP1 Related Classifications
HY-P4809 Related Classifications
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