872043-01-1
Chemical Structure
Polybia-MP1
- CAS. Nr.: 872043-01-1
- Formula:C78H132N20O19
- Molecular Weight:1654.01
InChIKey: WQWSKHPVGKVCQT-KXOXSZQSSA-N
SMILES: CC(C)C[C@@H](C(N)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(N)=O)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](C)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@@H](NC([C@H](CC(O)=O)NC([C@@H](N)[C@@H](C)CC)=O)=O)CC1=CNC2=CC=CC=C12)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: Polybia-MP1 is an antimicrobial peptide with antibacterial, antifungal and anticancer activities. Polybia-MP1 selectively targets cancer cells by interacting with PS and PE in the outer leaflet of cell membranes, and induces necrosis via pore formation. Polybia-MP1 exhibits antibacterial activity against Pseudomonas aeruginosa. Polybia-MP1 can be used in research related to bacterial infections, fungal infections and cancers[1][2][3].
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Polybia-MP1 | 99.03% | Polybia-MP1 is an antimicrobial peptide with antibacterial, antifungal and anticancer activities. Polybia-MP1 selectively targets cancer cells by interacting with PS and PE in the outer leaflet of cell membranes, and induces necrosis via pore formation. Polybia-MP1 exhibits antibacterial activity against Pseudomonas aeruginosa. Polybia-MP1 can be used in research related to bacterial infections, fungal infections and cancers. | ||||||||||||||||||||
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References
- [1]. dos Santos Cabrera MP, et al. Selectivity in the mechanism of action of antimicrobial mastoparan peptide Polybia-MP1. Eur Biophys J. 2008;37(6):879-891. [Content Brief]
- [2]. Alvares DS, et al. The antimicrobial peptide Polybia-MP1 differentiates membranes with the hopanoid, diplopterol from those with cholesterol. BBA Adv. 2021;1:100002. Published 2021 Jan 30. [Content Brief]
- [3]. Xuan HL, et al. Chemical approaches in the development of natural nontoxic peptide Polybia-MP1 as a potential dual antimicrobial and antitumor agent. Amino Acids. 2021;53(6):843-852. [Content Brief]
