Meropenem-vaborbactam  (Synonyms: Carbavance)

Meropenem-vaborbactam (Carbavance) is a Carbapenem Antibiotic and Boronic acid-based beta-lactamase inhibitor, is a fixed-dose combination product with potent in vitro activity against Enterobacteriaceae that are Klebsiella pneumoniae carbapenemase producers. Meropenem-vaborbactam exhibits activity against Pseudomonas aeruginosa isolates , with an MIC₅₀ of 0.5 μg/mL and an MIC₉₀ of 8 μg/mL^[1][2].

Meropenem-vaborbactam (≤1-≤2 μg/mL) potently inhibits Enterobacteriaceae isolates, with an MIC₅₀ of ≤0.015 μg/mL and an MIC₉₀ of 0.06 μg/mL; 99.1% and 99.3% of the isolates are inhibited at concentrations of ≤1 μg/mL and ≤2 μg/mL, respectively^[1].
Meropenem-vaborbactam exhibits activity against isolates of Pseudomonas aeruginosa, with an MIC₅₀ of 0.5 μg/mL and an MIC₉₀ of 8 μg/mL^[1].
Meropenem-vaborbactam exhibits potent in vitro activity against 991 KPC-producing Enterobacterales strains, with an MIC₅₀ of 0.06 mg/L and an MIC₉₀ of 1 mg/L^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Meropenem-vaborbactam (meropenem 2 g, vaborbactam 8 mg/L; 3-hour infusion; every 8 hours) achieves bacteriostasis at an fAUC:MIC ratio of 9 and a 1-log₁₀ bacterial kill at an fAUC:MIC ratio of 38 in a neutropenic murine thigh model of KPC-producing Enterobacteriaceae infection^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

680.60

C₂₉H₄₁BN₄O₁₀S₂

2031124-72-6

Solid

Light yellow to yellow

OC(C1=C(S[C@H]2C[C@H](NC2)C(N(C)C)=O)[C@H](C)[C@@]([C@@]3([H])[C@H](O)C)([H])N1C3=O)=O.O=C(CC4=CC=CS4)N[C@@H]5B(O[C@@H](CC5)CC(O)=O)O

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Castanheira M, et al. Meropenem-Vaborbactam Tested against Contemporary Gram-Negative Isolates Collected Worldwide during 2014, Including Carbapenem-Resistant, KPC-Producing, Multidrug-Resistant, and Extensively Drug-Resistant Enterobacteriaceae. Antimicrob Agents Chemother. 2017;61(9):e00567-17. Published 2017 Aug 24.  [Content Brief]

  [2]. Petty LA, et al. Overview of meropenem-vaborbactam and newer antimicrobial agents for the treatment of carbapenem-resistant Enterobacteriaceae. Infect Drug Resist. 2018 Sep 12;11:1461-1472.  [Content Brief]