Meropenem-vaborbactam
Based on 1 Customer Validation
Meropenem-vaborbactam (Carbavance) is a Carbapenem Antibiotic and Boronic acid-based beta-lactamase inhibitor, is a fixed-dose combination product with potent in vitro activity against Enterobacteriaceae that are Klebsiella pneumoniae carbapenemase producers. Meropenem-vaborbactam exhibits activity against Pseudomonas aeruginosa isolates , with an MIC50 of 0.5 μg/mL and an MIC90 of 8 μg/mL.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 97.91%
- No. CAS: 2031124-72-6
- Fòrmula: C29H41BN4O10S2
- Peso molecular:680.60
-
Almacenamiento:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
Anti-Infection Compound Library
HY-L002
-
FDA-Approved Drug Library
HY-L022
-
Drug Repurposing Compound Library
HY-L035
-
Antibacterial Compound Library
HY-L049
-
FDA Approved & Pharmacopeial Drug Library
HY-L066
-
Antibiotics Library
HY-L067
-
Anti-Pulmonary Fibrosis Compound Library
HY-L125
-
Off-patent Drug Library
HY-L141
-
MCE Bioactive Compound Library
HY-L001V
-
Drug Repurposing Compound Library Plus
HY-L035P
-
FDA-Approved Drug Library Plus
HY-L022P
-
FDA-Approved Drug Library Mini
HY-L022M
Ver todos los productos específicos de isoformas Antibiotic
MoreVer todos los productos específicos de isoformas Beta-lactamase
More
Actividad biológica
Meropenem-vaborbactam (≤1-≤2 μg/mL) potently inhibits Enterobacteriaceae isolates, with an MIC50 of ≤0.015 μg/mL and an MIC90 of 0.06 μg/mL; 99.1% and 99.3% of the isolates are inhibited at concentrations of ≤1 μg/mL and ≤2 μg/mL, respectively[1].
Meropenem-vaborbactam exhibits activity against isolates of Pseudomonas aeruginosa, with an MIC50 of 0.5 μg/mL and an MIC90 of 8 μg/mL[1].
Meropenem-vaborbactam exhibits potent in vitro activity against 991 KPC-producing Enterobacterales strains, with an MIC50 of 0.06 mg/L and an MIC90 of 1 mg/L[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:neutropenic mice[2]
-
Dosage:meropenem 2 g; vaborbactam 8 mg/L (as combination)
-
Administration:3-hour infusion; every 8 hours
-
Result:Achieved bacteriostasis at an fAUC:MIC ratio of 9.
Achieved a 1-log10 kill against KPC-producing Enterobacteriaceae at an fAUC:MIC ratio of 38.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
No. CAS 2031124-72-6
-
Appearance Solid
-
Peso molecular 680.60
-
Fòrmula C29H41BN4O10S2
-
Color Light yellow to yellow
-
SMILES
OC(C1=C(S[C@H]2C[C@H](NC2)C(N(C)C)=O)[C@H](C)[C@@]([C@@]3([H])[C@H](O)C)([H])N1C3=O)=O.O=C(CC4=CC=CS4)N[C@@H]5B(O[C@@H](CC5)CC(O)=O)O
-
Synonyms
Carbavance
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvente y solubilidad
DMSO : 10 mg/mL (14.69 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
-
Ficha de datos (284 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
[1]. Castanheira M, et al. Meropenem-Vaborbactam Tested against Contemporary Gram-Negative Isolates Collected Worldwide during 2014, Including Carbapenem-Resistant, KPC-Producing, Multidrug-Resistant, and Extensively Drug-Resistant Enterobacteriaceae. Antimicrob Agents Chemother. 2017;61(9):e00567-17. Published 2017 Aug 24. [Content Brief]
[2]. Petty LA, et al. Overview of meropenem-vaborbactam and newer antimicrobial agents for the treatment of carbapenem-resistant Enterobacteriaceae. Infect Drug Resist. 2018 Sep 12;11:1461-1472. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4693 mL | 7.3465 mL | 14.6929 mL | 36.7323 mL |
| 5 mM | 0.2939 mL | 1.4693 mL | 2.9386 mL | 7.3465 mL | |
| 10 mM | 0.1469 mL | 0.7346 mL | 1.4693 mL | 3.6732 mL |
Meropenem-vaborbactam Related Classifications
HY-111521 Related Classifications
Powered by Bioz
- Meropenem-vaborbactam
- 2031124-72-6
- Carbavance
- Antibiotic
- Bacterial
- Beta-lactamase
- KPC serine carbapenemase
- complicated urinary tract infection
- Ambler class A serine beta-lactamases
- penicillin-binding proteins
- Enterobacteriaceae
- Pseudomonas aeruginosa
- Stenotrophomonas maltophilia
- Ambler class C serine beta-lactamases
- Acinetobacter spp.
- gram-negative bacterial infections
- Inhibitor
- inhibitor
- inhibit