Chrysin-7-O-glucuronide

Name: Chrysin-7-O-glucuronide
Brand: MedChemExpress
SKU: HY-N2376
Rating: 4.5 (1 reviews)

Cat. No.: HY-N2376 Purity: 99.47%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Chrysin-7-O-glucuronide is a flavonoid found in Scutellaria baicalensis. Chrysin-7-O-glucuronide inhibits α-glucosidase and α-amylase with IC₅₀ values of 612.13 and 980.73 μg/mL. Chrysin-7-O-glucuronide suppresses NF-κB signaling activity. Chrysin-7-O-glucuronide scavenges free radicals, acts as a tight junction protector, and mitigates intestinal mucosal barrier injury. Chrysin-7-O-glucuronide can be used for the research of type 2 diabetes and severe acute pancreatitis-induced intestinal mucosal barrier injury.

For research use only. We do not sell to patients.

Chrysin-7-O-glucuronide Chemical Structure

CAS No. : 35775-49-6

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Chrysin-7-O-glucuronide:

Chrysin-7-O-glucuronide (Standard) Get quote

1 Publications Citing Use of MCE Chrysin-7-O-glucuronide

•Appl Sci. 2023, 13(2), 860.

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Chrysin-7-O-glucuronide (0-2 mg/mL; 2 h) inhibits yeast α-glucosidase with an IC₅₀ of 612.13 μg/mL^[1].
Chrysin-7-O-glucuronide (0-2 mg/mL; 20 min) inhibits porcine pancreatic α-amylase with an IC₅₀ of 980.73 μg/mL^[1].
Chrysin-7-O-glucuronide (16 μM; 24 h) restores ZO-1 expression and tight junction structure in TNF-α-treated IEC-6 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:	IEC-6 cells
Concentration:	16 μM
Incubation Time:	24 h pretreated before TNF-α
Result:	Increased the fluorescence of ZO-1.

In Vivo

Chrysin-7-O-glucuronide (20 mg/kg; i.p.; every 6 hours) significantly ameliorates SAP-induced intestinal mucosal barrier injury in rats by suppressing NF-κB inflammatory signaling, reducing intestinal pathological damage, restoring tight junction integrity, and lowering systemic intestinal injury marker levels^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague-Dawley (male, 7-8 weeks old, 250 g, severe acute pancreatitis induced via intrapancreaticobiliary duct infusion of 5% sodium taurocholate solution)^[2]
Dosage:	20 mg/kg
Administration:	i.p.; every 6 h
Result:	Significantly alleviated intestinal epithelial structural abnormalities, as evidenced by reduced intestinal pathological scores. Partially restored goblet cell numbers compared to SAP controls. Decreased serum levels of intestinal injury markers (D-lactic acid, diamine oxidase, I-FABP, Zonulin) and serum endotoxin levels. Restored expression of the tight junction protein ZO-1 in intestinal epithelia. Reduced intestinal protein levels of HMGB1 and IL-1β. Decreased the proportion of p-p65 and p-IκBα-positive intestinal cells, indicating suppressed NF-κB inflammatory signaling.

Molecular Weight

430.36

Formula

C₂₁H₁₈O₁₀

CAS No.

35775-49-6

Appearance

Solid

Color

Off-white to yellow

SMILES

O=C1C2=C(O)C=C(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)C(O)=O)C=C2OC(C4=CC=CC=C4)=C1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (116.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3236 mL	11.6182 mL	23.2364 mL
5 mM	0.4647 mL	2.3236 mL	4.6473 mL
10 mM	0.2324 mL	1.1618 mL	2.3236 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.81 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.81 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (5.81 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.47%

Select Batch:

Data Sheet (281 KB) SDS (393 KB)

COA (251 KB) HNMR (181 KB) RP-HPLC (224 KB)

Handling Instructions (2659 KB)

References

[1]. Li K, et al. Inhibitory effects against α-glucosidase and α-amylase of the flavonoids-rich extract from Scutellaria baicalensis shoots and interpretation of structure-activity relationship of its eight flavonoids by a refined assign-score method. Chem Cent J. 2018;12(1):82. Published 2018 Jul 12. [Content Brief]

[2]. Liu JQ, et al. The efficacy and active compounds of Chaihuang Qingyi Huoxue granule to Ameliorate intestinal mucosal barrier injury in rats with severe acute pancreatitis by suppressing the HMGB1/TLR4/NF-κB signaling pathway. Int Immunopharmacol. 2025;144:113632. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3236 mL	11.6182 mL	23.2364 mL	58.0909 mL
	5 mM	0.4647 mL	2.3236 mL	4.6473 mL	11.6182 mL
	10 mM	0.2324 mL	1.1618 mL	2.3236 mL	5.8091 mL
	15 mM	0.1549 mL	0.7745 mL	1.5491 mL	3.8727 mL
	20 mM	0.1162 mL	0.5809 mL	1.1618 mL	2.9045 mL
	25 mM	0.0929 mL	0.4647 mL	0.9295 mL	2.3236 mL
	30 mM	0.0775 mL	0.3873 mL	0.7745 mL	1.9364 mL
	40 mM	0.0581 mL	0.2905 mL	0.5809 mL	1.4523 mL
	50 mM	0.0465 mL	0.2324 mL	0.4647 mL	1.1618 mL
	60 mM	0.0387 mL	0.1936 mL	0.3873 mL	0.9682 mL
	80 mM	0.0290 mL	0.1452 mL	0.2905 mL	0.7261 mL
	100 mM	0.0232 mL	0.1162 mL	0.2324 mL	0.5809 mL