35775-49-6
Chemical Structure
Chrysin-7-O-glucuronide
- CAS No.: 35775-49-6
- Formula:C21H18O10
- Molecular Weight:430.36
IUPAC Name: (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid
InChIKey: IDRSJGHHZXBATQ-ZFORQUDYSA-N
SMILES: O=C1C2=C(O)C=C(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)C(O)=O)C=C2OC(C4=CC=CC=C4)=C1
Biological Activity: Chrysin-7-O-glucuronide is a flavonoid found in Scutellaria baicalensis. Chrysin-7-O-glucuronide inhibits α-glucosidase and α-amylase with IC50 values of 612.13 and 980.73 μg/mL. Chrysin-7-O-glucuronide suppresses NF-κB signaling activity. Chrysin-7-O-glucuronide scavenges free radicals, acts as a tight junction protector, and mitigates intestinal mucosal barrier injury. Chrysin-7-O-glucuronide can be used for the research of type 2 diabetes and severe acute pancreatitis-induced intestinal mucosal barrier injury[1][2].
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Chrysin-7-O-glucuronide | 99.47% | Chrysin-7-O-glucuronide is a flavonoid found in Scutellaria baicalensis. Chrysin-7-O-glucuronide inhibits α-glucosidase and α-amylase with IC50 values of 612.13 and 980.73 μg/mL. Chrysin-7-O-glucuronide suppresses NF-κB signaling activity. Chrysin-7-O-glucuronide scavenges free radicals, acts as a tight junction protector, and mitigates intestinal mucosal barrier injury. Chrysin-7-O-glucuronide can be used for the research of type 2 diabetes and severe acute pancreatitis-induced intestinal mucosal barrier injury. | ||||||||||||||||||||
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Chrysin-7-O-glucuronide (Standard) | ≥98% | Chrysin-7-O-glucuronide (Standard) is the analytical standard of Chrysin-7-O-glucuronide (Hy-N2376). This product is intended for research and analytical applications. Chrysin-7-O-glucuronide is a flavonoid found in Scutellaria baicalensis. Chrysin-7-O-glucuronide inhibits α-glucosidase and α-amylase with IC50 values of 612.13 and 980.73 μg/mL. Chrysin-7-O-glucuronide suppresses NF-κB signaling activity. Chrysin-7-O-glucuronide scavenges free radicals, acts as a tight junction protector, and mitigates intestinal mucosal barrier injury. Chrysin-7-O-glucuronide can be used for the research of type 2 diabetes and severe acute pancreatitis-induced intestinal mucosal barrier injury. | ||||||||||||||||||||
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-
Similarity Score 0.88
HY-N1454Apigenin-7-glucuronide -
Similarity Score 0.86
HY-N12028Acacetin 7-O-glucuronide -
Similarity Score 0.85
HY-N20679Aequinetin -
Similarity Score 0.83
HY-N1463RLuteolin 7-O-glucuronide (Standard) -
Similarity Score 0.83
HY-N0197Baicalin -
Similarity Score 0.81
HY-N13404Apigenin 7-O-methylglucuronide -
Similarity Score 0.81
HY-N6879RDiosMetin 7-O-β-D-Glucuronide (Standard) -
Similarity Score 0.81
HY-N2481Oroxylin A-7-O-glucuronide -
Similarity Score 0.80
HY-N8034Glychionide A -
Explore the MedChemAI to find more analogs
References
- [1]. Li K, et al. Inhibitory effects against α-glucosidase and α-amylase of the flavonoids-rich extract from Scutellaria baicalensis shoots and interpretation of structure-activity relationship of its eight flavonoids by a refined assign-score method. Chem Cent J. 2018;12(1):82. Published 2018 Jul 12. [Content Brief]
- [2]. Liu JQ, et al. The efficacy and active compounds of Chaihuang Qingyi Huoxue granule to Ameliorate intestinal mucosal barrier injury in rats with severe acute pancreatitis by suppressing the HMGB1/TLR4/NF-κB signaling pathway. Int Immunopharmacol. 2025;144:113632. [Content Brief]
