1. Metabolic Enzyme/Protease
  2. MMP

Apigenin-7-glucuronide (Synonyms: Apigenin 7-O-glucuronide)

Cat. No.: HY-N1454
Handling Instructions

Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.

For research use only. We do not sell to patients.

Apigenin-7-glucuronide Chemical Structure

Apigenin-7-glucuronide Chemical Structure

CAS No. : 29741-09-1

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5 mg USD 150 Get quote
10 mg USD 250 Get quote
25 mg USD 450 Get quote

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.

IC50 & Target

MMP-3

12.87 μM (IC50)

MMP-8

22.39 μM (IC50)

MMP-9

17.52 μM (IC50)

MMP13

0.27 μM (IC50)

In Vitro

Apigenin-7-Oglucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively [1]. Scutellarin A also inhibits the migrated capacity of ACHN and 786-O cells in a dose-dependent manner. It is also revealed that after treatment with Scutellarin A (30, 60, and 90 μM) for 24 h, the apoptosis rates in ACHN and 786-O cells are remarkably enhanced dose-dependently when compared to the control groups[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2403 mL 11.2017 mL 22.4034 mL
5 mM 0.4481 mL 2.2403 mL 4.4807 mL
10 mM 0.2240 mL 1.1202 mL 2.2403 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

446.36

Formula

C₂₁H₁₈O₁₁

CAS No.

29741-09-1

SMILES

O[[email protected]]([[email protected]]([[email protected]@H]([[email protected]@H](C(O)=O)O1)O)O)[[email protected]@H]1OC2=CC(O)=C3C(C=C(C4=CC=C(O)C=C4)OC3=C2)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Apigenin-7-glucuronide
Cat. No.:
HY-N1454
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Apigenin-7-glucuronide

Cat. No.: HY-N1454