Sesquiterpenoids from Chrysanthemum indicum with Inhibitory Effects on NO Production

  • J Nat Prod. 2021 Mar 26;84(3):562-569. doi: 10.1021/acs.jnatprod.0c01121.
Jun Gu Kim  1 ,  Jin Woo Lee  1 ,  Thi Phuong Linh Le  1 ,  Jae Sang Han  1 ,  Yong Beom Cho  1 ,  Haeun Kwon  2 ,  Dongho Lee  2 ,  Mi Kyeong Lee  1 ,  Bang Yeon Hwang  1
Affiliations
  • 1. College of Pharmacy, Chungbuk National University, Cheongju 28160, South Korea.
  • 2. Department of Plant Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, South Korea.
PMID: 33667099 DOI: 10.1021/acs.jnatprod.0c01121
Abstract

Three new guaianolide lactones (1-3) and four new 9-oxonerolidol glucosides (5-8) together with 20 known compounds were isolated from the MeOH extract of the flowers of Chrysanthemum indicum. Their structures were elucidated based on the interpretation of NMR, HRESIMS, and electronic circular dichroism (ECD) data along with acid hydrolysis. Of the isolates, sesquiterpenoids 1-4 and 15 and Flavones 17 and 18 exhibited inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide production in RAW 264.7 cells with IC50 values in the range 0.2-27.0 μM.