Glychionide A 

Glychionide A is a flavonoside that can be found in the roots of Glychirriza glabra. Glychionide A promotes apoptosis and autophagy of PANC-1 pancreatic cancer cells. Glychionide A can be used for the research of cancer^[1][2].

Glychionide A (3.12-100 μM) significantly inhibits the proliferation of the PANC-1 pancreatic cancer cells, with an IC₅₀ of 14 μM^[1].
Glychionide A (7-28 μM) induces both autophagy and apoptosis in pancreatic cancer cells^[1].
Glychionide A (7-28 μM) causes G2/M arrest of PANC-1 pancreatic cancer cells^[1].
Glychionide A (7-28 μM) causes generation of ROS in PANC-1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

446.36

C₂₁H₁₈O₁₁

119152-50-0

Solid

Light yellow to yellow

O=C1C(C(OC(C2=CC=CC=C2)=C1)=C3O)=C(C=C3O[C@@H]([C@@H]([C@H]4O)O)O[C@@H]([C@H]4O)C(O)=O)O

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Li JR, et, al. Two new compounds from Glycyrrhiza glabra. J Asian Nat Prod Res. 2005 Aug;7(4):677-80.  [Content Brief]

  [2]. Yu L, et, al. Antitumor Effects of Glychionide-A Flavonoid in Human Pancreatic Carcinoma Cells Are Mediated by Activation of Apoptotic and Autophagic Pathways, Cell Cycle Arrest, and Disruption of Mitochondrial Membrane Potential. Med Sci Monit. 2019 Feb  [Content Brief]